1ERV : HUMAN THIOREDOXIN MUTANT WITH CYS 73 REPLACED BY SER (REDUCED FORM)

Experimental Technique/Method:X-RAY DIFFRACTION Resolution:1.65 Classification:OXIDOREDUCTASE Release Date:1996-10-14 Deposition Date:1996-02-07 Revision Date:2008-03-24#2011-07-13 Molecular Weight:11734.41 Macromolecule Type:Protein Residue Count:105 Atom Site Count:822 DOI:10.2210/pdb1erv/pdb Abstract: Human thioredoxin reduces the disulfide bonds of numerous proteins in vitro, and can activate transcription factors such as NFkB in vivo. Thioredoxin can also act as a growth factor, and is overexpressed and secreted in certain tumor cells.