2N7T : NMR structure of Peptide PG-992 in DPC micelles

Experimental Technique/Method:SOLUTION NMR Resolution: Classification:DE NOVO PROTEIN Release Date:2015-12-16 Deposition Date:2015-09-17 Revision Date:2016-01-06#2017-10-11 Molecular Weight:1223.45 Macromolecule Type:Protein Residue Count:10 Atom Site Count:89 DOI:10.2210/pdb2n7t/pdb Abstract: The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated pathophysiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective ligands. Here, we report the design, synthesis, biological activity, conformational analysis, and docking with receptors of two potent and selective agonists at the human MC3 receptor.