Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation

  • Juhyung Lee (Creator)
  • Yue Xu (Creator)
  • Layla Saidi (Creator)
  • Miao Xu (Creator)
  • Konrad E Zinsmaier (Creator)
  • Yihong Ye (Creator)
  • Miao Xu (Creator)



Mutations in DNAJC5/CSPα are associated with adult neuronal ceroid lipofuscinosis (ANCL), a dominant-inherited neurodegenerative disease featuring lysosome-derived autofluorescent storage materials (AFSMs) termed lipofuscin. Functionally, DNAJC5 has bee...
Date made available2022
PublisherTaylor & Francis

Cite this