Advanced therapeutic inhalation aerosols of a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor for targeted pulmonary drug delivery in pulmonary hypertension: design, characterization, aerosolization, in vitro 2D/3D human lung cell cultures, and in vivo efficacy

  • Maria F. Acosta (Creator)
  • Priya Muralidharan (Creator)
  • Carissa L. Grijalva (Creator)
  • Michael D. Abrahamson (Creator)
  • Don Hayes (Creator)
  • Jeffrey R. Fineman (Creator)
  • Stephen M. Black (Creator)
  • Heidi Mansour (Creator)
  • Jeffrey R. Fineman (Creator)
  • Stephen M. Black (Creator)

Dataset

Description

Inhalable nanostructured microparticles of simvastatin, a Nrf2 activator and RhoA/Rho kinase (ROCK) inhibitor, were rationally designed for targeted pulmonary delivery as dry powder inhalers (DPIs) for the treatment of pulmonary hypertension (PH). Advan...
Date made available2021
PublisherSAGE Journals

Access Dataset

Cite this