Characterization and preclinical evaluation of a protease activated receptor 2 (PAR2) monoclonal antibody as a preventive therapy for migraine

  • Caroline Machado Kopruszinski (Creator)
  • Peter Thornton (Creator)
  • Joanne Arnold (Creator)
  • Philip Newton (Creator)
  • David Lowne (Creator)
  • Edita Navratilova (Creator)
  • Juliana Swiokla (Creator)
  • David W. Dodick (Creator)
  • Claire Dobson (Creator)
  • Ian Gurrell (Creator)
  • Iain Chessell (Creator)
  • Frank Porreca (Creator)

Dataset

Description

AimMigraine pain is thought to result from activation of meningeal nociceptors that might involve dural mast cell degranulation and release of proteases and pronociceptive mediators. Tryptase, the most abundant dural mast cell protease, has been demonst...
Date made available2020
PublisherSAGE Journals

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