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Dive into the research topics where Christopher Hulme is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Expeditious, biologically driven Pilot Libraries for File Enhancement
Hulme, C. (PI)
Project: Research project
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DYRK1A Inhibition as a Novel Treatment Approach for Alzheimer's Disease
Hulme, C. (CoPI), Hulme, C. (CoPI) & Hulme, C. (PI)
Project: Research project
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The Southwest Comprehensive Center for Drug Discovery and Development
Hulme, C. (CoPI)
Project: Research project
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Commercialization of Selective Dyrk1a Inhibitors for Down Syndrome
Hulme, C. (CoPI)
Project: Research project
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Expeditious, biologically driven Pilot Libraries for File Enhancement
Hulme, C. (PI)
8/5/10 → 5/31/14
Project: Research project
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Deuterated reagents in multicomponent reactions to afford deuterium-labeled products
Schofield, K., Maddern, S., Zhang, Y., Mastin, G. E., Knight, R., Wang, W., Galligan, J. & Hulme, C., 2024, In: Beilstein Journal of Organic Chemistry. 20, p. 2270-2279 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Discovery and Functional Characterization of a Potent, Selective, and Metabolically Stable PROTAC of the Protein Kinases DYRK1A and DYRK1B
Wilms, G., Schofield, K., Maddern, S., Foley, C., Shaw, Y., Smith, B., Basantes, L. E., Schwandt, K., Babendreyer, A., Chavez, T., McKee, N., Gokhale, V., Kallabis, S., Meissner, F., Rokey, S. N., Dunckley, T., Montfort, W. R., Becker, W. & Hulme, C., Oct 10 2024, In: Journal of Medicinal Chemistry. 67, 19, p. 17259-17289 31 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner
Strine, M. S., Cai, W. L., Wei, J., Alfajaro, M. M., Filler, R. B., Biering, S. B., Sarnik, S., Chow, R. D., Patil, A., Cervantes, K. S., Collings, C. K., DeWeirdt, P. C., Hanna, R. E., Schofield, K., Hulme, C., Konermann, S., Doench, J. G., Hsu, P. D., Kadoch, C. & Yan, Q. & 1 others, , Jun 2023, In: PLoS biology. 21, 6 June, e3002097.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
The full spectrum tuning of fluorescent molecules via a one-pot multicomponent reaction
Bedard, N., Coen, A. G., Pekarske, S., Sennett, A., Davis, G. J., Chavez, T., Lichtenberger, D. L. & Hulme, C., Oct 25 2023, In: Tetrahedron Letters. 130, 154748.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity
Zhu, B., Parsons, T., Foley, C., Shaw, Y., Dunckley, T., Hulme, C. & Hodge, J. J. L., Dec 2022, In: Scientific reports. 12, 1, 15847.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations
Datasets
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CCDC 992449: Experimental Crystal Structure Determination
Ayaz, M. (Creator), Xu, Z. (Creator) & Hulme, C. (Creator), Cambridge Crystallographic Data Centre, 2014
DOI: 10.5517/cc129qhl, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc129qhl&sid=DataCite
Dataset
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CCDC 873779: Experimental Crystal Structure Determination
Xu, Z. (Creator), De Moliner, F. (Creator), Cappelli, A. P. (Creator) & Hulme, C. (Creator), Cambridge Crystallographic Data Centre, 2013
DOI: 10.5517/ccyb7fx, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccyb7fx&sid=DataCite
Dataset
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CCDC 941766: Experimental Crystal Structure Determination
Xu, Z. (Creator), Shaw, A. Y. (Creator), Dietrich, J. (Creator), Cappelli, A. P. (Creator), Nichol, G. (Creator) & Hulme, C. (Creator), Cambridge Crystallographic Data Centre, 2013
DOI: 10.5517/cc10lzk4, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc10lzk4&sid=DataCite
Dataset
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CCDC 941765: Experimental Crystal Structure Determination
Xu, Z. (Creator), Shaw, A. Y. (Creator), Dietrich, J. (Creator), Cappelli, A. P. (Creator), Nichol, G. (Creator) & Hulme, C. (Creator), Cambridge Crystallographic Data Centre, 2013
DOI: 10.5517/cc10lzj3, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc10lzj3&sid=DataCite
Dataset
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CCDC 1027637: Experimental Crystal Structure Determination
Xu, Z. (Creator), Martinez-Ariza, G. (Creator), Cappelli, A. P. (Creator), Roberts, S. A. (Creator) & Hulme, C. (Creator), Cambridge Crystallographic Data Centre, 2015
DOI: 10.5517/cc13hblj, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc13hblj&sid=DataCite
Dataset