Daniela C Zarnescu

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5 Not started

Characterization of a novel Fragile X interacting gene
Zarnescu, D. C. (PI)
Project: Research project
Deciphering RNA based mechanisms of neurodegeneration
Zarnescu, D. C. (PI)
Project: Research project
Translation dysregulation in neurodegeneration
Zarnescu, D. C. (CoPI)
Project: Research project
Mechanisms underlying the protective role of glycolysis in ALS
Zarnescu, D. C. (PI)
Project: Research project
RNA dysregulation in neurodegeneration
Zarnescu, D. C. (PI)
Project: Research project

40 Article
9 Review article
2 Chapter
1 Conference contribution
More
- 1 Comment/debate
- 1 Short survey

Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits
Godfrey, R. K., Alsop, E., Bjork, R. T., Chauhan, B. S., Ruvalcaba, H. C., Antone, J., Gittings, L. M., Michael, A. F., Williams, C., Hala’ufia, G., Blythe, A. D., Hall, M., Sattler, R., Van Keuren-Jensen, K. & Zarnescu, D. C., Dec 2023, In: Acta neuropathologica communications. 11, 1, 168.
Research output: Contribution to journal › Article › peer-review

Open Access
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
Hung, S. T., Linares, G. R., Chang, W. H., Eoh, Y., Krishnan, G., Mendonca, S., Hong, S., Shi, Y., Santana, M., Kueth, C., Macklin-Isquierdo, S., Perry, S., Duhaime, S., Maios, C., Chang, J., Perez, J., Couto, A., Lai, J., Li, Y. & Alworth, S. V. & 8 others, Hendricks, E., Wang, Y., Zlokovic, B. V., Dickman, D. K., Parker, J. A., Zarnescu, D. C., Gao, F. B. & Ichida, J. K., Feb 16 2023, In: Cell. 186, 4, p. 786-802.e28
Research output: Contribution to journal › Article › peer-review
37 Scopus citations
Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production
Bjork, R. T., Mortimore, N. P., Loganathan, S. & Zarnescu, D. C., Mar 7 2022, In: Frontiers in Neuroscience. 16, 840357.
Research output: Contribution to journal › Review article › peer-review

Open Access
19 Scopus citations
TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS
Loganathan, S., Wilson, B. A., Carey, S. B., Manzo, E., Joardar, A., Ugur, B. & Zarnescu, D. C., Feb 2022, In: Metabolites. 12, 2, 101.
Research output: Contribution to journal › Article › peer-review

Open Access
5 Scopus citations
Author Correction: Mutations disrupting neuritogenesis genes confer risk for cerebral palsy (Nature Genetics, (2020), 52, 10, (1046-1056), 10.1038/s41588-020-0695-1)
Jin, S. C., Lewis, S. A., Bakhtiari, S., Zeng, X., Sierant, M. C., Shetty, S., Nordlie, S. M., Elie, A., Corbett, M. A., Norton, B. Y., van Eyk, C. L., Haider, S., Guida, B. S., Magee, H., Liu, J., Pastore, S., Vincent, J. B., Brunstrom-Hernandez, J., Papavasileiou, A. & Fahey, M. C. & 57 others, Berry, J. G., Harper, K., Zhou, C., Zhang, J., Li, B., Zhao, H., Heim, J., Webber, D. L., Frank, M. S. B., Xia, L., Xu, Y., Zhu, D., Zhang, B., Sheth, A. H., Knight, J. R., Castaldi, C., Tikhonova, I. R., López-Giráldez, F., Keren, B., Whalen, S., Buratti, J., Doummar, D., Cho, M., Retterer, K., Millan, F., Wang, Y., Waugh, J. L., Rodan, L., Cohen, J. S., Fatemi, A., Lin, A. E., Phillips, J. P., Feyma, T., MacLennan, S. C., Vaughan, S., Crompton, K. E., Reid, S. M., Reddihough, D. S., Shang, Q., Gao, C., Novak, I., Badawi, N., Wilson, Y. A., McIntyre, S. J., Mane, S. M., Wang, X., Amor, D. J., Zarnescu, D. C., Lu, Q., Xing, Q., Zhu, C., Bilguvar, K., Padilla-Lopez, S., Lifton, R. P., Gecz, J., MacLennan, A. H. & Kruer, M. C., Mar 2021, In: Nature Genetics. 53, 3, p. 412 1 p.
Research output: Contribution to journal › Comment/debate › peer-review

Open Access
2 Scopus citations

Additional file 1 of TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6
Lehmkuhl, E. M. (Creator), Loganathan, S. (Contributor), Alsop, E. (Creator), Blythe, A. D. (Creator), Kovalik, T. (Creator), Mortimore, N. P. (Creator), Barrameda, D. (Creator), Kueth, C. (Contributor), Eck, R. J. (Creator), Siddegowda, B. B. (Creator), Joardar, A. (Contributor), Ball, H. (Creator), Macias, M. E. (Creator), Bowser, R. (Creator), Van Keuren-Jensen, K. (Contributor), Zarnescu, D. C. (Creator) & Keuren-Jensen, K. V. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.14299503.v1, https://springernature.figshare.com/articles/dataset/Additional_file_1_of_TDP-43_proteinopathy_alters_the_ribosome_association_of_multiple_mRNAs_including_the_glypican_Dally-like_protein_Dlp_GPC6/14299503/1
Dataset
Additional file 3 of TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6
Lehmkuhl, E. M. (Creator), Loganathan, S. (Contributor), Alsop, E. (Creator), Blythe, A. D. (Creator), Kovalik, T. (Creator), Mortimore, N. P. (Creator), Barrameda, D. (Creator), Kueth, C. (Contributor), Eck, R. J. (Creator), Siddegowda, B. B. (Creator), Joardar, A. (Contributor), Ball, H. (Creator), Macias, M. E. (Creator), Bowser, R. (Creator), Van Keuren-Jensen, K. (Contributor), Zarnescu, D. C. (Creator) & Keuren-Jensen, K. V. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.14299509.v1, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_TDP-43_proteinopathy_alters_the_ribosome_association_of_multiple_mRNAs_including_the_glypican_Dally-like_protein_Dlp_GPC6/14299509/1
Dataset
Additional file 4 of TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6
Lehmkuhl, E. M. (Creator), Loganathan, S. (Contributor), Alsop, E. (Creator), Blythe, A. D. (Creator), Kovalik, T. (Creator), Mortimore, N. P. (Creator), Barrameda, D. (Creator), Kueth, C. (Contributor), Eck, R. J. (Creator), Siddegowda, B. B. (Creator), Joardar, A. (Contributor), Ball, H. (Creator), Macias, M. E. (Creator), Bowser, R. (Creator), Van Keuren-Jensen, K. (Contributor), Zarnescu, D. C. (Creator) & Keuren-Jensen, K. V. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.14299512.v1, https://springernature.figshare.com/articles/dataset/Additional_file_4_of_TDP-43_proteinopathy_alters_the_ribosome_association_of_multiple_mRNAs_including_the_glypican_Dally-like_protein_Dlp_GPC6/14299512/1
Dataset
TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6
Lehmkuhl, E. M. (Creator), Loganathan, S. (Contributor), Alsop, E. (Creator), Blythe, A. D. (Creator), Kovalik, T. (Creator), Mortimore, N. P. (Creator), Barrameda, D. (Creator), Kueth, C. (Contributor), Eck, R. J. (Creator), Siddegowda, B. B. (Creator), Joardar, A. (Contributor), Ball, H. (Creator), Macias, M. E. (Creator), Bowser, R. (Creator), Van Keuren-Jensen, K. (Contributor), Zarnescu, D. C. (Creator) & Keuren-Jensen, K. V. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.c.5352381.v1, https://springernature.figshare.com/collections/TDP-43_proteinopathy_alters_the_ribosome_association_of_multiple_mRNAs_including_the_glypican_Dally-like_protein_Dlp_GPC6/5352381/1
Dataset
Additional file 2 of TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6
Lehmkuhl, E. M. (Creator), Loganathan, S. (Contributor), Alsop, E. (Creator), Blythe, A. D. (Creator), Kovalik, T. (Creator), Mortimore, N. P. (Creator), Barrameda, D. (Creator), Kueth, C. (Contributor), Eck, R. J. (Creator), Siddegowda, B. B. (Creator), Joardar, A. (Contributor), Ball, H. (Creator), Macias, M. E. (Creator), Bowser, R. (Creator), Van Keuren-Jensen, K. (Contributor), Zarnescu, D. C. (Creator) & Keuren-Jensen, K. V. (Creator), figshare, 2021
DOI: 10.6084/m9.figshare.14299506.v1, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_TDP-43_proteinopathy_alters_the_ribosome_association_of_multiple_mRNAs_including_the_glypican_Dally-like_protein_Dlp_GPC6/14299506/1
Dataset

Daniela C Zarnescu

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Characterization of a novel Fragile X interacting gene

Deciphering RNA based mechanisms of neurodegeneration

Translation dysregulation in neurodegeneration

Mechanisms underlying the protective role of glycolysis in ALS

RNA dysregulation in neurodegeneration

Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits

PIKFYVE inhibition mitigates disease in models of diverse forms of ALS

Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production

TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS

Author Correction: Mutations disrupting neuritogenesis genes confer risk for cerebral palsy (Nature Genetics, (2020), 52, 10, (1046-1056), 10.1038/s41588-020-0695-1)

Additional file 1 of TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6

Additional file 3 of TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6

Additional file 4 of TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6

TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6

Additional file 2 of TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6

Daniela C Zarnescu

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Collaborations and top research areas from the last five years

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