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Dive into the research topics where Hendrikus L Granzier is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Myofilament-based mechanisms of diastolic dysfunction in HFpEF
Granzier, H. L. (PI)
Project: Research project
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Kbtbd13 knockdown restores muscle function in a clinically relevant mouse model of nemaline myopathy type 6
Galli, R. A., Vonk, L. A., Baelde, R. J., van Den Heuvel, A., Bogaards, S., Conijn, S., Siteur, E., Alekhina, O., Granzier, H., Irving, T., Ma, W., Bouman, K., van Engelen, B., van der Maarel, S. M., Kirby, T. J., Voermans, N., de Winter, J. & Ottenheijm, C. A. C., Jun 24 2026, In: Science translational medicine. 18, 855, eadx2116.Research output: Contribution to journal › Article › peer-review
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RBM20 isoform regulation by independent transcription start sites adapts alternative splicing in development and disease
Radke, M. H., Badillo Lisakowski, V., Meinke, S., Britto-Borges, T., Schneider-Lunitz, V., Hummel, O., van Heesch, S., Ruiz Orera, J., Hubner, N., Granzier, H., Dieterich, C. & Gotthardt, M., Dec 2026, In: Nature communications. 17, 1, 4607.Research output: Contribution to journal › Article › peer-review
Open Access -
Titin's P-zone domains A164-167 are essential for thick filament structural arrangement
Hoover Browne, C., Han, S. W., Farman, G. P., Smith, J. E., Kolb, J., Gohlke, J., Langlais, P. R., Tonino, P., Methawasin, M., van der Pijl, R. & Granzier, H., May 4 2026, In: The Journal of general physiology. 158, 3Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency
Methawasin, M., Strom, J., Marino, V. A., Gohlke, J., Muldoon, J., Herrick, S. R., van der Piji, R., Konhilas, J. P. & Granzier, H., Apr 2025, In: American Journal of Physiology - Heart and Circulatory Physiology. 328, 4, p. H719-H733Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Scopus citations -
Corrigendum: An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency (Am J Physiol Heart Circ Physiol (2025) 328 (H719–H733) DOI: 10.1152/ajpheart.00575.2024)
Methawasin, M., Strom, J., Marino, V. A., Gohlke, J., Muldoon, J., Herrick, S. R., van der Pijl, R., Konhilas, J. P. & Granzier, H., Jul 2025, In: American Journal of Physiology - Heart and Circulatory Physiology. 329, 1, p. H213Research output: Contribution to journal › Comment/debate › peer-review
Open Access
Datasets
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NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy
Ranu, N. (Creator), Witting, N. (Creator), Granzier, H. L. M. (Creator), Wallgren-Pettersson, C. (Creator), Vissing, J. (Creator), Voermans, N. C. (Creator), Moggio, M. G. (Creator), Kontrogianni-Konstantopoulos, A. (Creator), Mariano, J. M. (Creator), Fiorillo, C. (Creator), Huovinen, S. P. (Creator), Auranen, M. P. (Creator), Ochala, J. (Creator), Zanoteli, E. (Creator), Palmio, J. (Creator), Kolb, J. S. (Creator) & Beck, T. N. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.c.6582904, https://springernature.figshare.com/collections/NEB_mutations_disrupt_the_super-relaxed_state_of_myosin_and_remodel_the_muscle_metabolic_proteome_in_nemaline_myopathy/6582904
Dataset
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Phosphodiesterase 9a Inhibition in Mouse Models of Diastolic Dysfunction
Strom, J. (Creator), Borkowski, T. (Creator), Hourani, Z. (Creator), Smith, J. E. (Creator), Granzier, H. (Creator) & Methawasin, M. (Creator), University of Arizona Research Data Repository, 2023
DOI: 10.25422/azu.data.22122197, https://arizona.figshare.com/articles/dataset/Phosphodiesterase_9a_Inhibition_in_Mouse_Models_of_Diastolic_Dysfunction/22122197
Dataset
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Partial deletion of titin's C-zone alters cardiac function by reducing the operating sarcomere length range
Farman, G. P. (Creator), Granzier-Nakajima, S. (Creator), Strom, J. (Creator), Kiss, B. (Creator), Smith, J. E. (Creator), Granzier, H. (Creator) & Methawasin, M. (Creator), University of Arizona Research Data Repository, 2023
DOI: 10.25422/azu.data.22239415.v1, https://arizona.figshare.com/articles/dataset/Partial_deletion_of_titin_s_C-zone_alters_cardiac_function_by_reducing_the_operating_sarcomere_length_range/22239415/1
Dataset
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Supplementary material from "Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I"
Bogomolovas, J. (Creator), Fleming, J. R. (Creator), Anderson, B. R. (Creator), Williams, R. (Creator), Lange, S. (Creator), Simon, B. (Creator), Khan, M. M. (Contributor), Rudolf, R. (Creator), Franke, B. (Creator), Bullard, B. (Creator), Rigden, D. J. (Creator), Granzier, H. (Creator), Labeit, S. (Creator) & Mayans, O. (Creator), figshare, 2016
DOI: 10.6084/m9.figshare.c.3469731, https://figshare.com/collections/Supplementary_material_from_Exploration_of_pathomechanisms_triggered_by_a_single-nucleotide_polymorphism_in_titin_s_I-band_the_cardiomyopathy-linked_mutation_T2580I_/3469731
Dataset
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Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on muscle structure and function
Li, F. (Creator), Kolb, J. (Creator), Crudele, J. (Creator), Hourani, Z. (Creator), Smith, J. E. (Creator), Chamberlain, J. S. (Creator), Granzier, H. (Creator), Chamberlain, J. (Creator) & Granzier, H. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.c.4834359, https://springernature.figshare.com/collections/Expressing_a_Z-disk_nebulin_fragment_in_nebulin-deficient_mouse_muscle_effects_on_muscle_structure_and_function/4834359
Dataset