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Collaborations and top research areas from the last five years
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Myofilament-based mechanisms of diastolic dysfunction in HFpEF
Granzier, H. L. (PI)
Project: Research project
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Role of the giant protein titin in cardiac health and disease
Granzier, H. L. (CoPI) & Granzier, H. L. (PI)
Project: Research project
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An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency
Methawasin, M., Strom, J., Marino, V. A., Gohlke, J., Muldoon, J., Herrick, S. R., van der Piji, R., Konhilas, J. P. & Granzier, H., Apr 2025, In: American Journal of Physiology - Heart and Circulatory Physiology. 328, 4, p. H719-H733Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations -
Corrigendum: An ovary-intact postmenopausal HFpEF mouse model; menopause is more than just estrogen deficiency (Am J Physiol Heart Circ Physiol (2025) 328 (H719–H733) DOI: 10.1152/ajpheart.00575.2024)
Methawasin, M., Strom, J., Marino, V. A., Gohlke, J., Muldoon, J., Herrick, S. R., van der Pijl, R., Konhilas, J. P. & Granzier, H., Jul 2025, In: American Journal of Physiology - Heart and Circulatory Physiology. 329, 1, p. H213Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Differential sex-dependent susceptibility to diastolic dysfunction and arrhythmia in cardiomyocytes from obese diabetic heart failure with preserved ejection fraction model
Hernandez, J. M., Shen, E. Y., Ko, C. Y., Hourani, Z., Spencer, E. R., Smoliarchuk, D., Bossuyt, J., Granzier, H., Bers, D. M. & Hegyi, B., Jan 1 2025, In: Cardiovascular research. 121, 2, p. 254-266 13 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Link opens in a new tab Scopus citations -
Discovery of Titin and Its Role in Heart Function and Disease
Granzier, H. L. & Labeit, S., Jan 3 2025, In: Circulation research. 136, 1, p. 135-157 23 p.Research output: Contribution to journal › Review article › peer-review
20 Link opens in a new tab Scopus citations -
Generation of a novel mouse model of nemaline myopathy due to recurrent NEB exon 55 deletion
Coulson, Z., Kolb, J., Sabha, N., Karimi, E., Hourani, Z., Ottenheijm, C., Granzier, H. & Dowling, J. J., Dec 2025, In: Skeletal muscle. 15, 1, 8.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on muscle structure and function
Li, F. (Creator), Kolb, J. (Creator), Crudele, J. (Creator), Hourani, Z. (Creator), Smith, J. E. (Creator), Chamberlain, J. S. (Creator), Granzier, H. (Creator), Chamberlain, J. (Creator) & Granzier, H. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.c.4834359.v1, https://springernature.figshare.com/collections/Expressing_a_Z-disk_nebulin_fragment_in_nebulin-deficient_mouse_muscle_effects_on_muscle_structure_and_function/4834359/1
Dataset
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Partial deletion of titin's C-zone alters cardiac function by reducing the operating sarcomere length range
Farman, G. P. (Creator), Granzier-Nakajima, S. (Creator), Strom, J. (Creator), Kiss, B. (Creator), Smith, J. E. (Creator), Granzier, H. (Creator) & Methawasin, M. (Creator), University of Arizona Research Data Repository, 2023
DOI: 10.25422/azu.data.22239415, https://arizona.figshare.com/articles/dataset/Partial_deletion_of_titin_s_C-zone_alters_cardiac_function_by_reducing_the_operating_sarcomere_length_range/22239415
Dataset
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Expressing a Z-disk nebulin fragment in nebulin-deficient mouse muscle: effects on muscle structure and function
Li, F. (Creator), Kolb, J. (Creator), Crudele, J. (Creator), Hourani, Z. (Creator), Smith, J. E. (Creator), Chamberlain, J. S. (Creator), Granzier, H. (Creator), Chamberlain, J. (Creator) & Granzier, H. (Creator), figshare, 2020
DOI: 10.6084/m9.figshare.c.4834359, https://springernature.figshare.com/collections/Expressing_a_Z-disk_nebulin_fragment_in_nebulin-deficient_mouse_muscle_effects_on_muscle_structure_and_function/4834359
Dataset
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Phosphodiesterase 9a Inhibition in Mouse Models of Diastolic Dysfunction
Strom, J. (Creator), Borkowski, T. (Creator), Hourani, Z. (Creator), Smith, J. E. (Creator), Granzier, H. (Creator) & Methawasin, M. (Creator), University of Arizona Research Data Repository, 2023
DOI: 10.25422/azu.data.22122197, https://arizona.figshare.com/articles/dataset/Phosphodiesterase_9a_Inhibition_in_Mouse_Models_of_Diastolic_Dysfunction/22122197
Dataset
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NEB mutations disrupt the super-relaxed state of myosin and remodel the muscle metabolic proteome in nemaline myopathy
Kontrogianni-Konstantopoulos, A. (Creator), Kolb, J. S. (Creator), Palmio, J. (Creator), Beck, T. N. (Creator), Moggio, M. G. (Creator), Witting, N. (Creator), Voermans, N. C. (Creator), Zanoteli, E. (Creator), Fiorillo, C. (Creator), Auranen, M. P. (Creator), Wallgren-Pettersson, C. (Creator), Huovinen, S. P. (Creator), Ranu, N. (Creator), Granzier, H. L. M. (Creator), Ochala, J. (Creator), Mariano, J. M. (Creator) & Vissing, J. (Creator), figshare, 2024
DOI: 10.6084/m9.figshare.c.6582904.v1, https://springernature.figshare.com/collections/NEB_mutations_disrupt_the_super-relaxed_state_of_myosin_and_remodel_the_muscle_metabolic_proteome_in_nemaline_myopathy/6582904/1
Dataset