Jennifer S Carew

2023

Comprehensive Single-Cell Immune Profiling Defines the Patient Multiple Myeloma Microenvironment Following Oncolytic Virus Therapy in a Phase Ib Trial

Nawrocki, S. T., Olea, J., Celi, C. V., Dadrastoussi, H., Wu, K., Tsao-Wei, D., Colombo, A., Coffey, M., Hernandez, E. F., Chen, X., Nuovo, G. J., Carew, J. S., Mohrbacher, A. F., Fields, P., Kuhn, P., Siddiqi, I., Merchant, A. & Kelly, K. R., Dec 15 2023, In: Clinical Cancer Research. 29, 24, p. 5087-5103 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

The Novel Lysosomal Autophagy Inhibitor (ROC-325) Ameliorates Experimental Pulmonary Hypertension

Bao, C., Liang, S., Han, Y., Yang, Z., Liu, S., Sun, Y., Zheng, S., Li, Y., Wang, T., Gu, Y., Wu, K., Black, S. M., Wang, J., Nawrocki, S. T., Carew, J. S., Yuan, J. X. J. & Tang, H., Jan 1 2023, In: Hypertension. 80, 1, p. 70-83 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2022

Targeted CUL4A inhibition synergizes with cisplatin to yield long-term survival in models of head and neck squamous cell carcinoma through a DDB2-mediated mechanism

Jones, T. M., Espitia, C. M., Ooi, A., Bauman, J. E., Carew, J. S. & Nawrocki, S. T., Apr 2022, In: Cell Death and Disease. 13, 4, 350.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1-Mutant Myelodysplastic Syndromes With Ringed Sideroblasts

Adema, V., Ma, F., Kanagal-Shamanna, R., Thongon, N., Montalban-Bravo, G., Yang, H., Peslak, S. A., Wang, F., Acha, P., Sole, F., Lockyer, P., Cassari, M., Maciejewski, J. P., Visconte, V., Gañán-Gómez, I., Song, Y., Bueso-Ramos, C., Pellegrini, M., Tan, T. M. & Bejar, R. & 8 others, Carew, J. S., Halene, S., Santini, V., Al-Atrash, G., Clise-Dwyer, K., Garcia-Manero, G., Blobel, G. A. & Colla, S., Nov 1 2022, In: Blood cancer discovery. 3, 6, p. 554-567 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2021

A Phase II Trial of Imatinib Mesylate as Maintenance Therapy for Patients With Newly Diagnosed C-kit–positive Acute Myeloid Leukemia

Advani, A. S., Tse, W., Li, H., Jia, X., Elson, P., Cooper, B., Ali-Osman, F., Park, J., Rao, A. V., Rizzieri, D. A., Wang, E. S., Cotta, C. V., Kalaycio, M., Sobecks, R. M., Rouphail, B., Maciejewski, J. P., Fensterl, J., Carew, J. S., Foster, B. & Rush, M. L. & 5 others, Tripp, B., Adams, D., Corrigan, D., Griffiths, E. A. & Sekeres, M. A., Feb 2021, In: Clinical Lymphoma, Myeloma and Leukemia. 21, 2, p. 113-118 6 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Targeting JAK/STAT signaling antagonizes resistance to oncolytic reovirus therapy driven by prior infection with HTLV-1 in models of T-cell lymphoma

Islam, S., Espitia, C. M., Persky, D. O., Carew, J. S. & Nawrocki, S. T., Jul 2021, In: Viruses. 13, 7, 1406.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2020

ABCG2 overexpression contributes to pevonedistat resistance

Kathawala, R. J., Espitia, C. M., Jones, T. M., Islam, S., Gupta, P., Zhang, Y. K., Chen, Z. S., Carew, J. S. & Nawrocki, S. T., Feb 2020, In: Cancers. 12, 2, 429.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Resistance to histone deacetylase inhibitors confers hypersensitivity to oncolytic reovirus therapy

Islam, S., Espitia, C. M., Persky, D. O., Carew, J. S. & Nawrocki, S. T., Oct 27 2020, In: Blood Advances. 4, 20, p. 5297-5310 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Therapeutic targeting of autophagy for renal cell carcinoma therapy

Jones, T. M., Carew, J. S. & Nawrocki, S. T., May 2020, In: Cancers. 12, 5, 1185.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

2019

A phase I/II trial of MEC (mitoxantrone, etoposide, cytarabine) in combination with ixazomib for relapsed refractory acute myeloid leukemia

Advani, A. S., Cooper, B., Visconte, V., Elson, P., Chan, R., Carew, J., Wei, W., Mukherjee, S., Gerds, A., Carraway, H., Nazha, A., Hamilton, B., Sobecks, R., Caimi, P., Tomlinson, B., Malek, E., Little, J., Miron, A., Pink, J. & Maciejewski, J. & 4 others, Unger, A., Kalaycio, M., de Lima, M. & Sekeres, M. A., 2019, In: Clinical Cancer Research. 25, 14, p. 4231-4237 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Heightened JNK activation and reduced XIAP levels promote TRAIL and sunitinib-mediated apoptosis in colon cancer models

Mahalingam, D., Carew, J. S., Espitia, C. M., Cool, R. H., Giles, F. J., De Jong, S. & Nawrocki, S. T., Jul 2019, In: Cancers. 11, 7, 895.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Plinabulin, an inhibitor of tubulin polymerization, targets KRAS signaling through disruption of endosomal recycling

Cimino, P. J., Huang, L., Du, L., Wu, Y., Bishop, J., Dalsing-Hernandez, J., Kotlarczyk, K., Gonzales, P., Carew, J., Nawrocki, S., Jordan, M. A., Wilson, L., Lloyd, G. K. & Wirsching, H. G., Apr 2019, In: Biomedical Reports. 10, 4, p. 218-224 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Rational cotargeting of HDAC6 and BET proteins yields synergistic antimyeloma activity

Carew, J. S., Espitia, C. M., Zhao, W., Visconte, V., Anwer, F., Kelly, K. R. & Nawrocki, S. T., 2019, In: Blood Advances. 3, 8, p. 1318-1329 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

2017

Disruption of autophagic degradation with ROC-325 antagonizes renal cell carcinoma pathogenesis

Carew, J. S., Espitia, C. M., Zhao, W., Han, Y., Visconte, V., Phillips, J. & Nawrocki, S. T., Jun 1 2017, In: Clinical Cancer Research. 23, 11, p. 2869-2879 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

56 Scopus citations

Oncolytic reovirus inhibits angiogenesis through induction of CXCL10/ip-10 and abrogation of HIF activity in soft tissue sarcomas

Carew, J. S., Espitia, C. M., Zhao, W., Mita, M. M., Mita, A. C. & Nawrocki, S. T., Oct 17 2017, In: Oncotarget. 8, 49, p. 86769-86783 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

2016

Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline

Liu, P. P., Liu, J., Jiang, W. Q., Carew, J. S., Ogasawara, M. A., Pelicano, H., Croce, C. M., Estrov, Z., Xu, R. H., Keating, M. J. & Huang, P., Oct 27 2016, In: Oncogene. 35, 43, p. 5663-5673 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Scopus citations

2015

Junctional adhesion molecule-A is overexpressed in advanced multiple myeloma and determines response to oncolytic reovirus

Kelly, K. R., Espitia, C. M., Zhao, W., Wendlandt, E., Tricot, G., Zhan, F., Carew, J. S. & Nawrocki, S. T., 2015, In: Oncotarget. 6, 38, p. 41275-41289 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Targeting survivin inhibits renal cell carcinoma progression and enhances the activity of temsirolimus

Carew, J. S., Espitia, C. M., Zhao, W., Mita, M. M., Mita, A. C. & Nawrocki, S. T., Jun 1 2015, In: Molecular Cancer Therapeutics. 14, 6, p. 1404-1413 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

The NEDD8-activating enzyme inhibitor MLN4924 disrupts nucleotide metabolism and augments the efficacy of cytarabine

Nawrocki, S. T., Kelly, K. R., Smith, P. G., Keaton, M., Carraway, H., Sekeres, M. A., Maciejewski, J. P. & Carew, J. S., Jan 15 2015, In: Clinical Cancer Research. 21, 2, p. 439-447 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

2014

Combined autophagy and HDAC inhibition: A phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors

Mahalingam, D., Mita, M., Sarantopoulos, J., Wood, L., Amaravadi, R. K., Davis, L. E., Mita, A. C., Curiel, T. J., Espitia, C. M., Nawrocki, S. T., Giles, F. J. & Carew, J. S., Aug 2014, In: Autophagy. 10, 8, p. 1403-1414 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

244 Scopus citations

2013

Disrupting protein NEDDylation with MLN4924 is a novel strategy to target cisplatin resistance in ovarian cancer

Nawrocki, S. T., Kelly, K. R., Smith, P. G., Espitia, C. M., Possemato, A., Beausoleil, S. A., Milhollen, M., Blakemore, S., Thomas, M., Berger, A. & Carew, J. S., Jul 1 2013, In: Clinical Cancer Research. 19, 13, p. 3577-3590 14 p.

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Reolysin is a novel reovirus-based agent that induces endoplasmic reticular stress-mediated apoptosis in pancreatic cancer

Carew, J. S., Espitia, C. M., Zhao, W., Kelly, K. R., Coffey, M., Freeman, J. W. & Nawrocki, S. T., Jul 2013, In: Cell Death and Disease. 4, 7, e728.

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

2012

Adenosine A2A and beta-2 adrenergic receptor agonists: Novel selective and synergistic multiple myeloma targets discovered through systematic combination screening

Rickles, R. J., Tam, W. F., Giordano, T. P., Pierce, L. T., Farwell, M., McMillin, D. W., Necheva, A., Crowe, D., Chen, M., Avery, W., Kansra, V., Nawrocki, S. T., Carew, J. S., Giles, F. J., Mitsiades, C. S., Borisy, A. A., Anderson, K. C. & Lee, M. S., Jul 2012, In: Molecular Cancer Therapeutics. 11, 7, p. 1432-1442 11 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

An adaptive Src-PDGFRA-Raf axis in rhabdomyosarcoma

Abraham, J., Chua, Y. X., Glover, J. M., Tyner, J. W., Loriaux, M. M., Kilcoyne, A., Giles, F. J., Nelon, L. D., Carew, J. S., Ouyang, Y., Michalek, J. E., Pal, R., Druker, B. J., Rubin, B. P. & Keller, C., Sep 28 2012, In: Biochemical and Biophysical Research Communications. 426, 3, p. 363-368 6 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Elr510444 inhibits tumor growth and angiogenesis by abrogating hif activity and disrupting microtubules in renal cell carcinoma

Carew, J. S., Esquivel, J. A., Espitia, C. M., Schultes, C. M., Mülbaier, M., Lewis, J. D., Janssen, B., Giles, F. J. & Nawrocki, S. T., Jan 25 2012, In: PloS one. 7, 1, e31120.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J. U., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Al-Younes, H. M., Al-Zeer, M. A., Albert, M. L., Albin, R. L. & Alegre-Abarrategui, J. & 1,251 others, Aleo, M. F. R., Alirezaei, M., Almasan, A., Almonte-Becerril, M., Amano, A., Amaravadi, R., Amarnath, S., Amer, A. O., Andrieu-Abadie, N., Anantharam, V., Ann, D. K., Anoopkumar-Dukie, S., Aoki, H., Apostolova, N., Arancia, G., Aris, J. P., Asanuma, K., Asare, N. Y. O., Ashida, H., Askanas, V., Askew, D. S., Auberger, P., Baba, M., Backues, S. K., Baehrecke, E. H., Bahr, B. A., Bai, X. Y., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Bamber, B. A., Bampton, E. T. W., Bánhegyi, G., Bartholomew, C. R., Bassham, D. C., Bast, R. C., Batoko, H., Bay, B. H., Beau, I., Béchet, D. M., Begley, T. J., Behl, C., Behrends, C., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Bernassola, F., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Blum, J. S., Boise, L. H., Bonaldo, P., Boone, D. L., Bornhauser, B. C., Bortoluci, K. R., Bossis, I., Bost, F., Bourquin, J. P., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Brenman, J. E., Brennand, A., Bresnick, E. H., Brest, P., Bridges, D., Bristol, M. L., Brookes, P. S., Brown, E. J., Brumell, J. H., Brunetti-Pierri, N., Brunk, U. T., Bulman, D. E., Bultman, S. J., Bultynck, G., Burbulla, L. F., Bursch, W., Butchar, J. P., Buzgariu, W., Bydlowski, S. P., Cadwell, K., Cahová, M., Cai, D., Cai, J., Cai, Q., Calabretta, B., Calvo-Garrido, J., Camougrand, N., Campanella, M., Campos-Salinas, J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Carew, J. S., Carlin, C. R., Carmignac, V., Carneiro, L. A. M., Carra, S., Caruso, R. A., Casari, G., Casas, C., Castino, R., Cebollero, E., Cecconi, F., Celli, J., Chaachouay, H., Chae, H. J., Chai, C. Y., Chan, D. C., Chan, E. Y., Chang, R. C. H. C., Che, C. M., Chen, C. C., Chen, G. C., Chen, G. Q., Chen, M., Chen, Q., Chen, S. S. L., Chen, W. L., Chen, X., Chen, X., Chen, X., Chen, Y. G., Chen, Y., Chen, Y., Chen, Y. J., Chen, Z., Cheng, A., Cheng, C. H. K., Cheng, Y., Cheong, H., Cheong, J. H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H. L., Chiarelli, R., Chiba, T., Chin, L. S., Chiou, S. H., Chisari, F. V., Cho, C. H. I., Cho, D. H., Choi, A. M. K., Choi, D. S., Choi, K. S. O., Choi, M. E., Chouaib, S., Choubey, D., Choubey, V., Chu, C. T., Chuang, T. H., Chueh, S. H., Chun, T., Chwae, Y. J., Chye, M. L., Ciarcia, R., Ciriolo, M. R., Clague, M. J., Clark, R. S. B., Clarke, P. G. H., Clarke, R., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condello, M., Condorelli, F., Cookson, M. R., Coombs, G. H., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Cregg, J. M., Crespo, J. L., Cronjé, M. J., Cuervo, A. M. A., Cullen, J. J., Czaja, M. J., D'Amelio, M., Darfeuille-Michaud, A., Davids, L. M., Davies, F. E., De Felici, M., de Groot, J. F., de Haan, C. A. M., De Martino, L., De Milito, A., De Tata, V., Debnath, J., Degterev, A., Dehay, B., Delbridge, L. M. D., Demarchi, F., Deng, Y. Z. H., Dengjel, J., Dent, P., Denton, D., Deretic, V., Desai, S. D., Devenish, R. J., Di Gioacchino, M., Di Paolo, G., Di Pietro, C., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, M. T., Diaz-Nido, J., Dikic, I., Dinesh-Kumar, S. P., Ding, W. X., Distelhorst, C. W., Diwan, A., Djavaheri-Mergny, M., Dokudovskaya, S., Dong, Z., Dorsey, F. C., Dosenko, V., Dowling, J. J., Doxsey, S., Dreux, M., Drew, M. E., Duan, Q., Duchosal, M. A., Duff, K., Dugail, I., Durbeej, M., Duszenko, M., Edelstein, C. L., Edinger, A. L., Egea, G., Eichinger, L., Eissa, N. T., Ekmekcioglu, S., El-Deiry, W. S., Elazar, Z., Elgendy, M., Ellerby, L. M., Eng, K. E. R., Engelbrecht, A. M., Engelender, S., Erenpreisa, J., Escalante, R., Esclatine, A., Eskelinen, E. L., Espert, L., Espina, V., Fan, H., Fan, J., Fan, Q. W., Fan, Z., Fang, S., Fang, Y., Fanto, M., Fanzani, A., Farkas, T., Farré, J. C., Faure, M., Fechheimer, M., Feng, C. G., Feng, J., Feng, Q., Feng, Y., Fésüs, L., Feuer, R., Figueiredo-Pereira, M. E., Fimia, G. M. A., Fingar, D. C., Finkbeiner, S., Finkel, T., Finley, K. D., Fiorito, F., Fisher, E. A., Fisher, P. B., Flajolet, M., Florez-McClure, M. L., Florio, S., Fon, E. A., Fornai, F., Fortunato, F., Fotedar, R., Fowler, D. H., Fox, H. S., Franco, R., Frankel, L. B., Fransen, M., Fuentes, J. M., Fueyo, J., Fujii, J., Fujisaki, K., Fujita, E., Fukuda, M., Furukawa, R. H., Gaestel, M., Gailly, P., Gajewska, M., Galliot, B., Galy, V., Ganesh, S., Ganetzky, B., Ganley, I. G., Gao, F. B., Gao, G. F., Gao, J., Garcia, L., Garcia-Manero, G., Garcia-Marcos, M., Garmyn, M., Gartel, A. L., Gatti, E., Gautel, M., Gawriluk, T. R., Gegg, M. E., Geng, J., Germain, M., Gestwicki, J. E., Gewirtz, D. A., Ghavami, S., Ghosh, P., Giammarioli, A. M., Giatromanolaki, A. N., Gibson, S. B., Gilkerson, R. W., Ginger, M. L., Ginsberg, H. N., Golab, J., Goligorsky, M. S., Golstein, P., Gomez-Manzano, C., Goncu, E., Gongora, C., Gonzalez, C. D., Gonzalez, R., González-Estévez, C., González-Polo, R. A. N., Gonzalez-Rey, E., Gorbunov, N. V., Gorski, S., Goruppi, S., Gottlieb, R. A., Gozuacik, D., Granato, G. E. L., Grant, G. D., Green, K. N., Gregorc, A., Gros, F., Grose, C., Grunt, T. W., Gual, P., Guan, J. L., Guan, K. L., Guichard, S. M., Gukovskaya, A. S., Gukovsky, I., Gunst, J., Gustafsson, A. B., Halayko, A. J., Hale, A. N., Halonen, S. K., Hamasaki, M., Han, F., Han, T., Hancock, M. K., Hansen, M., Harada, H., Harada, M., Hardt, S. E., Harper, J. W., Harris, A. L., Harris, J., Harris, S. D., Hashimoto, M., Haspel, J. A., Hayashi, S. I., Hazelhurst, L. A., He, C., He, Y. W., Hébert, M. J., Heidenreich, K. A., Helfrich, M. H., Helgason, G. V., Henske, E. P., Herman, B., Herman, P. K., Hetz, C., Hilfiker, S., Hill, J. A., Hocking, L. J., Hofman, P., Hofmann, T. G., Höhfeld, J., Holyoake, T. L., Hong, M. H., Hood, D. A., Hotamisligil, G. S., Houwerzijl, E. J., Høyer-Hansen, M., Hu, B., Hu, C. A. A., Hu, H. M., Hua, Y., Huang, C., Huang, J., Huang, S., Huang, W. P., Huber, T. B., Huh, W. K., Hung, T. H., Hupp, T. R., Hur, G. M. I., Hurley, J. B., Hussain, S. N. A., Hussey, P. J., Hwang, J. J. I., Hwang, S., Ichihara, A., Ilkhanizadeh, S., Inoki, K., Into, T., Iovane, V., Iovanna, J. L., Ip, N. Y., Isaka, Y., Ishida, H., Isidoro, C., Isobe, K. I., Iwasaki, A., Izquierdo, M., Izumi, Y., Jaakkola, P. M., Jäättelä, M., Jackson, G. R., Jackson, W. T., Janji, B., Jendrach, M., Jeon, J. H., Jeung, E. B., Jiang, H., Jiang, H., Jiang, J. X., Jiang, M., Jiang, Q., Jiang, X., Jiménez, A., Jin, M., Jin, S., Joe, C. O., Johansen, T., Johnson, D. E., Johnson, G. V. W., Jones, N. L., Joseph, B., Joseph, S. K., Joubert, A. M., Juhász, G., Juillerat-Jeanneret, L., Jung, C. H. W., Jung, Y. K., Kaarniranta, K., Kaasik, A., Kabuta, T., Kadowaki, M., Kagedal, K., Kamada, Y., Kaminskyy, V. O., Kampinga, H. H., Kanamori, H., Kang, C., Kang, K. B. E., Kang, K. I. L., Kang, R., Kang, Y. A., Kanki, T., Kanneganti, T. D., Kanno, H., Kanthasamy, A. G., Kanthasamy, A., Karantza, V., Kaushal, G. P., Kaushik, S., Kawazoe, Y., Ke, P. Y., Kehrl, J. H., Kelekar, A., Kerkhoff, C., Kessel, D. H., Khalil, H., Kiel, J. A. K. W., Kiger, A. A., Kihara, A., Kim, D. R. Y., Kim, D. H., Kim, D. H., Kim, E. K., Kim, H. R., Kim, J. S., Kim, J. H. U., Kim, J. C. H., Kim, J. K., Kim, P. K., Kim, S. W. H., Kim, Y. S., Kim, Y., Kimchi, A., Kimmelman, A. C., King, J. S., Kinsella, T. J., Kirkin, V., Kirshenbaum, L. A., Kitamoto, K., Kitazato, K., Klein, L., Klimecki, W. T., Klucken, J., Knecht, E., Ko, B. C. B., Koch, J. C., Koga, H., Koh, J. Y., Koh, Y. H. O., Koike, M., Komatsu, M., Kominami, E., Kong, H. J. E., Kong, W. J., Korolchuk, V. I., Kotake, Y., Koukourakis, M. I., Kouri Flores, J. B., Kovács, A. L., Kraft, C., Krainc, D., Krämer, H., Kretz-Remy, C., Krichevsky, A. M., Kroemer, G., Krüger, R., Krut, O., Ktistakis, N. T., Kuan, C. Y., Kucharczyk, R., Kumar, A., Kumar, R., Kumar, S., Kundu, M., Kung, H. J., Kurz, T., Kwon, H. J. E., La Spada, A. R., Lafont, F., Lamark, T., Landry, J., Lane, J. D., Lapaquette, P., Laporte, J. F., László, L., Lavandero, S., Lavoie, J. N., Layfield, R., Lazo, P. A., Le, W., Le Cam, L., Ledbetter, D. J., Lee, A. J. X., Lee, B. W., Lee, G. M. I., Lee, J., Lee, J. H., Lee, M., Lee, M. S., Lee, S. H. Y., Leeuwenburgh, C., Legembre, P., Legouis, R., Lehmann, M., Lei, H. Y., Lei, Q. Y., Leib, D. A., Leiro, J., Lemasters, J. J., Lemoine, A., Lesniak, M. 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C., Uchiyama, Y., Ueno, T., Umekawa, M., Umemiya-Shirafuji, R., Unni, V. K., Vaccaro, M. I., Valente, E. M. A., Van den Berghe, G., van der Klei, I. J., van Doorn, W., van Dyk, L. F., van Egmond, M., van Grunsven, L. A., Vandenabeele, P., Vandenberghe, W. P., Vanhorebeek, I., Vaquero, E. C., Velasco, G., Vellai, T., Vicencio, J. M. I., Vierstra, R. D., Vila, M., Vindis, C., Viola, G., Viscomi, M. T. E., Voitsekhovskaja, O. V., von Haefen, C., Votruba, M., Wada, K., Wade-Martins, R., Walker, C. L., Walsh, C. M., Walter, J., Wan, X. B., Wang, A., Wang, C., Wang, D., Wang, F., Wang, F., Wang, G., Wang, H., Wang, H. G., Wang, H. D., Wang, J., Wang, K., Wang, M., Wang, R. C., Wang, X., Wang, X., Wang, Y. J., Wang, Y., Wang, Z., Wang, Z. C. H., Wang, Z., Wansink, D. G., Ward, D. M., Watada, H., Waters, S. L., Webster, P., Wei, L., Weihl, C. C., Weiss, W. A., Welford, S. M., Wen, L. P., Whitehouse, C. A., Whitton, J. L., Whitworth, A. J., Wileman, T., Wiley, J. W., Wilkinson, S., Willbold, D., Williams, R. L., Williamson, P. R., Wouters, B. G., Wu, C., Wu, D. C., Wu, W. K. K., Wyttenbach, A., Xavier, R. J., Xi, Z., Xia, P., Xiao, G., Xie, Z., Xie, Z., Xu, D. Z., Xu, J., Xu, L., Xu, X., Yamamoto, A., Yamamoto, A., Yamashina, S., Yamashita, M., Yan, X., Yanagida, M., Yang, D. S., Yang, E., Yang, J. M., Yang, S. Y. U., Yang, W., Yang, W. Y. U., Yang, Z., Yao, M. C., Yao, T. P., Yeganeh, B., Yen, W. L., Yin, J. J., Yin, X. M., Yoo, O. J., Yoon, G., Yoon, S. Y., Yorimitsu, T., Yoshikawa, Y., Yoshimori, T., Yoshimoto, K., You, H. J. I., Youle, R. J., Younes, A., Yu, L., Yu, L., Yu, S. W., Yu, W. H. A., Yuan, Z. M., Yue, Z., Yun, C. H., Yuzaki, M., Zabirnyk, O., Silva-Zacarin, E., Zacks, D., Zacksenhaus, E., Zaffaroni, N., Zakeri, Z., Zeh, H. J., Zeitlin, S. O., Zhang, H., Zhang, H. L., Zhang, J., Zhang, J. P., Zhang, L., Zhang, L., Zhang, M. Y., Zhang, X. D. O., Zhao, M., Zhao, Y. F., Zhao, Y., Zhao, Z. J., Zheng, X., Zhivotovsky, B., Zhong, Q., Zhou, C. Z., Zhu, C., Zhu, W. G., Zhu, X. F., Zhu, X., Zhu, Y., Zoladek, T., Zong, W. X., Zorzano, A., Zschocke, J., Zuckerbraun, B., Terada, A. S. & Zacksenhaus, L., Apr 1 2012, In: Autophagy. 8, 4, p. 445-544 100 p.

Research output: Contribution to journal › Article › peer-review

2934 Scopus citations

Reovirus therapy stimulates endoplasmic reticular stress, NOXA induction, and augments bortezomib-mediated apoptosis in multiple myeloma

Kelly, K. R., Espitia, C. M., Mahalingam, D., Oyajobi, B. O., Coffey, M., Giles, F. J., Carew, J. S. & Nawrocki, S. T., Jun 21 2012, In: Oncogene. 31, 25, p. 3023-3038 16 p.

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism

Kelly, K. R., Nawrocki, S. T., Espitia, C. M., Zhang, M., Yang, J. J., Padmanabhan, S., Ecsedy, J., Giles, F. J. & Carew, J. S., Dec 1 2012, In: International Journal of Cancer. 131, 11, p. 2693-2703 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

2011

Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis

Carew, J. S., Espitia, C. M., Esquivel, J. A., Mahalingam, D., Kelly, K. R., Reddy, G., Giles, F. J. & Nawrocki, S. T., Feb 25 2011, In: Journal of Biological Chemistry. 286, 8, p. 6602-6613 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

126 Scopus citations

Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma

Mahalingam, D., Espitia, C. M., Medina, E. C., Esquivel, J. A., Kelly, K. R., Bearss, D., Choy, G., Taverna, P., Carew, J. S., Giles, F. J. & Nawrocki, S. T., Nov 8 2011, In: British journal of cancer. 105, 10, p. 1563-1573 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib

Kelly, K. R., Ecsedy, J., Medina, E., Mahalingam, D., Padmanabhan, S., Nawrocki, S. T., Giles, F. J. & Carew, J. S., Oct 2011, In: Journal of Cellular and Molecular Medicine. 15, 10, p. 2057-2070 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

72 Scopus citations

The Pim kinases: New targets for drug development

Swords, R., Kelly, K., Carew, J., Nawrocki, S., Mahalingam, D., Sarantopoulos, J., Bearss, D. & Giles, F., Dec 2011, In: Current Drug Targets. 12, 14, p. 2059-2066 8 p.

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

2010

Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation

Carew, J. S., Medina, E. C., Esquivel, J. A., Mahalingam, D., Swords, R., Kelly, K., Zhang, H., Huang, P., Mita, A. C., Mita, M. M., Giles, F. J. & Nawrocki, S. T., Oct 2010, In: Journal of Cellular and Molecular Medicine. 14, 10, p. 2448-2459 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

190 Scopus citations

Cdc7 kinase - A new target for drug development

Swords, R., Mahalingam, D., O'Dwyer, M., Santocanale, C., Kelly, K., Carew, J. & Giles, F., Jan 2010, In: European Journal of Cancer. 46, 1, p. 33-40 8 p.

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Inhibition of NEDD8-activating enzyme: A novel approach for the treatment of acute myeloid leukemia

Swords, R. T., Kelly, K. R., Smith, P. G., Garnsey, J. J., Mahalingam, D., Medina, E., Oberheu, K., Padmanabhan, S., O'Dwyer, M., Nawrocki, S. T., Giles, F. J. & Carew, J. S., May 6 2010, In: Blood. 115, 18, p. 3796-3800 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

232 Scopus citations

Vorinostat enhances the activity of temsirolimus in renal cell carcinoma through suppression of survivin levels

Mahalingam, D., Medina, E. C., Esquivel, J. A., Espitia, C. M., Smith, S., Oberheu, K., Swords, R., Kelly, K. R., Mita, M. M., Mita, A. C., Carew, J. S., Giles, F. J. & Nawrocki, S. T., Jan 1 2010, In: Clinical Cancer Research. 16, 1, p. 141-153 13 p.

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

2008

Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism

Zhang, H., Trachootham, D., Lu, W., Carew, J., Giles, F. J., Keating, M. J., Arlinghaus, R. B. & Huang, P., Jun 2008, In: Leukemia. 22, 6, p. 1191-1199 9 p.

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA

Nawrocki, S. T., Carew, J. S., Maclean, K. H., Courage, J. F., Huang, P., Houghton, J. A., Cleveland, J. L., Giles, F. J. & McConkey, D. J., Oct 1 2008, In: Blood. 112, 7, p. 2917-2926 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

105 Scopus citations

The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib

Carew, J. S., Nawrocki, S. T., Reddy, V. K., Bush, D., Rehg, J. E., Goodwin, A., Houghton, J. A., Casero, R. A., Marton, L. J. & Cleveland, J. L., Jun 15 2008, In: Cancer Research. 68, 12, p. 4783-4790 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

2007

Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21^Cip1-dependent decrease in survivin levels

Nawrocki, S. T., Carew, J. S., Douglas, L., Cleveland, J. L., Humphreys, R. & Houghton, J. A., Jul 15 2007, In: Cancer Research. 67, 14, p. 6987-6994 8 p.

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHAto overcome Bcr-Abl-mediated drug resistance

Carew, J. S., Nawrocki, S. T., Kahue, C. N., Zhang, H., Yang, C., Chung, L., Houghton, J. A., Huang, P., Giles, F. J. & Cleveland, J. L., Jul 1 2007, In: Blood. 110, 1, p. 313-322 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

438 Scopus citations

2006

Aggresome disruption: A novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells

Nawrocki, S. T., Carew, J. S., Pino, M. S., Highshaw, R. A., Andtbacka, R. H. I., Dunner, K., Pal, A., Bornmann, W. G., Chiao, P. J., Huang, P., Xiong, H., Abbruzzese, J. L. & McConkey, D. J., Apr 1 2006, In: Cancer Research. 66, 7, p. 3773-3781 9 p.

Research output: Contribution to journal › Article › peer-review

220 Scopus citations

Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism

Pelicano, H., Xu, R. H., Du, M., Feng, L., Sasaki, R., Carew, J. S., Hu, Y., Ramdas, L., Hu, L., Keating, M. J., Zhang, W., Plunkett, W. & Huang, P., Dec 18 2006, In: Journal of Cell Biology. 175, 6, p. 913-923 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

335 Scopus citations

Targeting endoplasmic reticulum protein transport: A novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL

Carew, J. S., Nawrocki, S. T., Krupnik, Y. V., Dunner, K., McConkey, D. J., Keating, M. J. & Huang, P., Jan 1 2006, In: Blood. 107, 1, p. 222-231 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

80 Scopus citations

Targeting Hsp90 by 17-AAG in leukemia cells: Mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C

Pelicano, H., Carew, J. S., McQueen, T. J., Andreeff, M., Plunkett, W., Keating, M. J. & Huang, P., Apr 2006, In: Leukemia. 20, 4, p. 610-619 10 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

2005

Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells

Nawrocki, S. T., Carew, J. S., Dunner, K., Boise, L. H., Chiao, P. J., Huang, P., Abbruzzese, J. L. & McConkey, D. J., Dec 15 2005, In: Cancer Research. 65, 24, p. 11510-11519 10 p.

Research output: Contribution to journal › Article › peer-review

283 Scopus citations

Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis

Nawrocki, S. T., Carew, J. S., Pino, M. S., Highshaw, R. A., Dunner, K., Huang, P., Abbruzzese, J. L. & McConkey, D. J., Dec 15 2005, In: Cancer Research. 65, 24, p. 11658-11666 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

269 Scopus citations

Combination of 5-fluorouracil and N¹,N¹¹- diethylnorspermine markedly activates spermidine/spermine N¹- acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells

Choi, W., Gerner, E. W., Ramdas, L., Dupart, J., Carew, J., Proctor, L., Huang, P., Zhang, W. & Hamilton, S. R., Feb 4 2005, In: Journal of Biological Chemistry. 280, 5, p. 3295-3304 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia

Xu, R. H., Pelicano, H., Zhou, Y., Carew, J. S., Feng, L., Bhalla, K. N., Keating, M. J. & Huang, P., Jan 15 2005, In: Cancer Research. 65, 2, p. 613-621 9 p.

Research output: Contribution to journal › Article › peer-review

742 Scopus citations

Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol γ

Achanta, G., Sasaki, R., Feng, L., Carew, J. S., Lu, W., Pelicano, H., Keating, M. J. & Huang, P., Oct 5 2005, In: EMBO Journal. 24, 19, p. 3482-3492 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

250 Scopus citations

Jennifer S Carew

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