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Collaborations and top research areas from the last five years
Grants
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Drug target validation of the enterovirus D68 2A protease
Wang, J. (PI) & Wang, J. (CoPI)
Project: Research project
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Drug Discovery Targeting the Influenza A Virus M2-S31N Proton Channel
Wang, J. (PI)
Project: Research project
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Development of dual inhibitors targeting the viral main protease and the host cathepsin L as SARS-CoV-2 antivirals
Wang, J. (PI) & Wang, J. (CoPI)
Project: Research project
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High Throughput Screening of Inhibitors Targeting the Enterovirus A71 and D68 2A proteases
Wang, J. (PI) & Wang, J. (CoPI)
Project: Research project
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Drug Discovery Targeting the Influenza A Virus M2-S31N Proton Channel
Wang, J. (CoPI) & Wang, J. (PI)
Project: Research project
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Structure-Based Design of Covalent SARS-CoV-2 Main Protease Inhibitors Targeting the Nirmatrelvir-Resistant E166 Mutants
Cai, Z., Kohaal, N., Georgiou, K., Liang, X., Chi, X., Tan, H., Tan, B., Li, K., Fan, G., Lambrinidis, G., Kolocouris, A., Deng, X., Chen, Y. & Wang, J., Jan 26 2026, In: JACS Au. 6, 1, p. 233-244 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A rationally designed 2C inhibitor prevents enterovirus D68-infected mice from developing paralysis
Li, K., Rudy, M. J., Hu, Y., Tan, H., Lambrinidis, G., Wu, X., Georgiou, K., Tan, B., Frost, J., Wilson, C., Clarke, P., Kolocouris, A., Zhang, Q. Y., Tyler, K. L. & Wang, J., Dec 2025, In: Nature communications. 16, 1, 5987.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Bat Influenza M2 Shows Functions Similar to Those of Classical Influenza A Viruses
Yang, W., Wang, L., Shi, L., Zhang, J., Liu, H., Wang, J. & Ma, W., Jun 2025, In: Pathogens. 14, 6, 599.Research output: Contribution to journal › Article › peer-review
Open Access -
Design of a Fluorescence Polarization Probe for Enterovirus 2C Proteins
Li, K., Demssie, H. A. & Wang, J., Jul 10 2025, In: Journal of Medicinal Chemistry. 68, 13, p. 14041-14053 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Identification of naturally occurring drug-resistant mutations of SARS-CoV-2 papain-like protease
Tan, H., Zhang, Q., Georgiou, K., Zhang, S., Li, K., Lambrinidis, G., Kolocouris, A., Deng, X. & Wang, J., Dec 2025, In: Nature communications. 16, 1, 4548.Research output: Contribution to journal › Article › peer-review
Open Access6 Link opens in a new tab Scopus citations
Datasets
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2KIX : Channel domain of BM2 protein from influenza B virus
Wang, J. (Contributor), Pielak, R. M. (Contributor), Chou, J. J. (Contributor), Wang, J. (Contributor) & McClintock, M. A. (Contributor), RCSB-PDB, 2009
DOI: 10.2210/pdb2kix/pdb, https://www.rcsb.org/structure/2KIX
Dataset
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2MUV : NOE-based model of the influenza A virus M2 (19-49) bound to drug 11
Wu, Y. (Contributor), Wang, J. (Contributor) & Degrado, W. F. (Contributor), RCSB-PDB, 2014
DOI: 10.2210/pdb2muv/pdb, https://www.rcsb.org/structure/2MUV
Dataset
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CCDC 1573497: Experimental Crystal Structure Determination
Zhang, J. (Creator), Hu, Y. (Creator), Foley, C. (Creator), Wang, Y. (Creator), Musharrafieh, R. (Creator), Xu, S. (Creator), Zhang, Y. (Creator), Ma, C. (Creator), Hulme, C. (Creator) & Wang, J. (Creator), Cambridge Crystallographic Data Centre, 2018
DOI: 10.5517/ccdc.csd.cc1ptbzt, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1ptbzt&sid=DataCite
Dataset
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2LY0 : Solution NMR structure of the influenza A virus S31N mutant (19-49) in presence of drug M2WJ332
Wu, Y. (Contributor), Wang, J. (Contributor) & Degrado, W. F. (Contributor), RCSB-PDB, 2013
DOI: 10.2210/pdb2ly0/pdb, https://www.rcsb.org/structure/2LY0
Dataset
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2Q06 : Crystal structure of Influenza A Virus H5N1 Nucleoprotein
Wang, J. (Contributor), Ng, A.K.-L. (Contributor), Zhang, H. (Contributor), Tan, K. (Contributor), Wang, J.-H. (Contributor) & Shaw, P.-C. (Contributor), RCSB-PDB, 2008
DOI: 10.2210/pdb2q06/pdb, https://www.rcsb.org/structure/2Q06
Dataset