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Collaborations and top research areas from the last five years
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Establishing a molecular system for drug targeting of transcriptional control
Hurley, L. (PI) & Hurley, L. (PI)
Project: Research project
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A synthetic lethal approach to drug targeting of G-quadruplexes based on CX-5461
Jin, M., Hurley, L. H. & Xu, H., Jul 15 2023, In: Bioorganic and Medicinal Chemistry Letters. 91, 129384.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461 (Pidnarulex)
Xu, H. & Hurley, L. H., Dec 1 2022, In: Bioorganic and Medicinal Chemistry Letters. 77, 129016.Research output: Contribution to journal › Review article › peer-review
40 Scopus citations -
Quindoline-derivatives display potent G-quadruplex-mediated antiviral activity against herpes simplex virus 1
Frasson, I., Soldà, P., Nadai, M., Tassinari, M., Scalabrin, M., Gokhale, V., Hurley, L. H. & Richter, S. N., Dec 2022, In: Antiviral Research. 208, 105432.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
The role of G-Quadruplex DNA in Paraspeckle formation in cancer
Bhatt, U., Kretzmann, A. L., Guédin, A., Ou, A., Kobelke, S., Bond, C. S., Evans, C. W., Hurley, L. H., Mergny, J. L., Iyer, K. S., Fox, A. H. & Smith, N. M., Nov 2021, In: Biochimie. 190, p. 124-131 8 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells
King, J. J., Irving, K. L., Evans, C. W., Chikhale, R. V., Becker, R., Morris, C. J., Peña Martinez, C. D., Schofield, P., Christ, D., Hurley, L. H., Waller, Z. A. E., Iyer, K. S. & Smith, N. M., Dec 9 2020, In: Journal of the American Chemical Society. 142, 49, p. 20600-20604 5 p.Research output: Contribution to journal › Article › peer-review
74 Scopus citations
Datasets
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In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells
Montoya, J. J. (Creator), Turnidge, M. A. (Creator), Wai, D. H. (Creator), Patel, A. R. (Contributor), Lee, D. W. (Creator), Gokhale, V. (Creator), Hurley, L. H. (Creator), Arceci, R. J. (Creator), Wetmore, C. (Creator) & Azorsa, D. O. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4799331.v1, https://springernature.figshare.com/collections/In_vitro_activity_of_a_G-quadruplex-stabilizing_small_molecule_that_synergizes_with_Navitoclax_to_induce_cytotoxicity_in_acute_myeloid_leukemia_cells/4799331/1
Dataset
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CCDC 858523: Experimental Crystal Structure Determination
Nichol, G. S. (Creator), Boddupally, P. V. L. (Creator), De, B. (Creator) & Hurley, L. H. (Creator), Cambridge Crystallographic Data Centre, 2012
DOI: 10.5517/ccxtc9c, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccxtc9c&sid=DataCite
Dataset