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Dive into the research topics where Laurence Hurley is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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DNA Quadruplex Control of hTERT Transcription: A New Therapy for Taxotere Resistant Prostate Cancer
Miranti, C. (CoPI) & Hurley, L. (PI)
Project: Research project
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Structural basis for nucleolin recognition of MYC promoter G-quadruplex
Chen, L., Dickerhoff, J., Zheng, K. W., Erramilli, S., Feng, H., Wu, G., Onel, B., Chen, Y., Wang, K. B., Carver, M., Lin, C., Sakai, S., Wan, J., Vinson, C., Hurley, L., Kossiakoff, A. A., Deng, N., Bai, Y., Noinaj, N. & Yang, D., Apr 18 2025, In: Science. 388, 6744, eadr1752.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
A synthetic lethal approach to drug targeting of G-quadruplexes based on CX-5461
Jin, M., Hurley, L. H. & Xu, H., Jul 15 2023, In: Bioorganic and Medicinal Chemistry Letters. 91, 129384.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461 (Pidnarulex)
Xu, H. & Hurley, L. H., Dec 1 2022, In: Bioorganic and Medicinal Chemistry Letters. 77, 129016.Research output: Contribution to journal › Review article › peer-review
51 Scopus citations -
Quindoline-derivatives display potent G-quadruplex-mediated antiviral activity against herpes simplex virus 1
Frasson, I., Soldà, P., Nadai, M., Tassinari, M., Scalabrin, M., Gokhale, V., Hurley, L. H. & Richter, S. N., Dec 2022, In: Antiviral Research. 208, 105432.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
The role of G-Quadruplex DNA in Paraspeckle formation in cancer
Bhatt, U., Kretzmann, A. L., Guédin, A., Ou, A., Kobelke, S., Bond, C. S., Evans, C. W., Hurley, L. H., Mergny, J. L., Iyer, K. S., Fox, A. H. & Smith, N. M., Nov 2021, In: Biochimie. 190, p. 124-131 8 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations
Datasets
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CCDC 858523: Experimental Crystal Structure Determination
Nichol, G. S. (Creator), Boddupally, P. V. L. (Creator), De, B. (Creator) & Hurley, L. H. (Creator), Cambridge Crystallographic Data Centre, 2012
DOI: 10.5517/ccxtc9c, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccxtc9c&sid=DataCite
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In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells
Montoya, J. J. (Creator), Turnidge, M. A. (Creator), Wai, D. H. (Creator), Patel, A. R. (Contributor), Lee, D. W. (Creator), Gokhale, V. (Creator), Hurley, L. H. (Creator), Arceci, R. J. (Creator), Wetmore, C. (Creator) & Azorsa, D. O. (Creator), figshare, 2019
DOI: 10.6084/m9.figshare.c.4799331.v1, https://springernature.figshare.com/collections/In_vitro_activity_of_a_G-quadruplex-stabilizing_small_molecule_that_synergizes_with_Navitoclax_to_induce_cytotoxicity_in_acute_myeloid_leukemia_cells/4799331/1
Dataset