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Dive into the research topics where Nancy C Horton is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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STRUCTURAL MECHANISMS OF DNA RECOGNITION AND CLEAVAGE BY SEQUENCE SPECIFIC DNA B
Horton, N. C. (PI)
Project: Research project
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STRUCTURAL MECHANISMS OF RECOGNITION AND CATALYSIS BY DNA MODIFYING ENZYMES
Horton, N. C. (PI)
Project: Research project
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STRUCTURE BASED APPROACH TO ISSUES IN ZINC FINGER RECOGNITION
Horton, N. C. (PI)
Project: Research project
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DNA Sequence Control of Enzyme Filamentation and Activation of the SgrAI Endonuclease
Ghadirian, N., Morgan, R. D. & Horton, N. C., Feb 6 2024, In: Biochemistry. 63, 3, p. 326-338 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Physachenolide C is a Potent, Selective BET Inhibitor
Zerio, C. J., Sivinski, J., Wijeratne, E. M. K., Xu, Y. M., Ngo, D. T., Ambrose, A. J., Villa-Celis, L., Ghadirian, N., Clarkson, M. W., Zhang, D. D., Horton, N. C., Gunatilaka, A. A. L., Fromme, R. & Chapman, E., Jan 12 2023, In: Journal of Medicinal Chemistry. 66, 1, p. 913-933 21 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
High-Resolution Structure of the Nuclease Domain of the Human Parvovirus B19 Main Replication Protein NS1
Sanchez, J. L., Ghadirian, N. & Horton, N. C., May 2022, In: Journal of virology. 96, 9Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Pretransition state and apo structures of the filamentforming enzyme SgrAI elucidate mechanisms of activation and substrate specificity
Shan, Z., Ghadirian, N., Lyumkis, D. & Horton, N. C., Apr 1 2022, In: Journal of Biological Chemistry. 298, 4, 101760.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI
Lyumkis, D. & Horton, N. C., Dec 2022, In: Biochemical Society transactions. 50, 6, p. 1703-1714 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations
Datasets
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4C3G : cryo-EM structure of activated and oligomeric restriction endonuclease SgrAI
Lyumkis, D. (Contributor), Talley, H. (Contributor), Stewart, A. (Contributor), Shah, S. (Contributor), Park, C. K. (Contributor), Tama, F. (Contributor), Potter, C. S. (Contributor), Carragher, B. (Contributor) & Horton, N. C. (Contributor), RCSB-PDB, 2013
DOI: 10.2210/pdb4c3g/pdb, https://www.rcsb.org/structure/4C3G
Dataset
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1STX : Structure of the K38A mutant of EcoRV bound to cognate DNA and Mn2+
Horton, N. C. (Contributor) & Perona, J. J. (Contributor), RCSB-PDB, 2004
DOI: 10.2210/pdb1stx/pdb, https://www.rcsb.org/structure/1STX
Dataset
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3E44 : Q138F HincII bound to cleaved DNA (GTT | AAC) and Mn2+
Babic, A. C. (Contributor), Little, E. J. (Contributor), Manohar, V. M. (Contributor) & Horton, N. C. (Contributor), RCSB-PDB, 2008
DOI: 10.2210/pdb3e44/pdb, https://www.rcsb.org/structure/3E44
Dataset
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3DPG : SgrAI with noncognate DNA bound
Dunten, P. W. (Contributor), Little, E. J. (Contributor) & Horton, N. C. (Contributor), RCSB-PDB, 2008
DOI: 10.2210/pdb3dpg/pdb, https://www.rcsb.org/structure/3DPG
Dataset
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3N7B : SgrAI bound to secondary site DNA and Ca(II)
Little, E. J. (Contributor), Dunten, P. W. (Contributor) & Horton, N. C. (Contributor), RCSB-PDB, 2010
DOI: 10.2210/pdb3n7b/pdb, https://www.rcsb.org/structure/3N7B
Dataset