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Dive into the research topics where Nancy C Horton is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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STRUCTURAL MECHANISMS OF DNA RECOGNITION AND CLEAVAGE BY SEQUENCE SPECIFIC DNA B
Horton, N. C. (PI)
Project: Research project
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STRUCTURAL MECHANISMS OF RECOGNITION AND CATALYSIS BY DNA MODIFYING ENZYMES
Horton, N. C. (PI)
Project: Research project
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STRUCTURE BASED APPROACH TO ISSUES IN ZINC FINGER RECOGNITION
Horton, N. C. (PI)
Project: Research project
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DNA Sequence Control of Enzyme Filamentation and Activation of the SgrAI Endonuclease
Ghadirian, N., Morgan, R. D. & Horton, N. C., Feb 6 2024, In: Biochemistry. 63, 3, p. 326-338 13 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Physachenolide C is a Potent, Selective BET Inhibitor
Zerio, C. J., Sivinski, J., Wijeratne, E. M. K., Xu, Y. M., Ngo, D. T., Ambrose, A. J., Villa-Celis, L., Ghadirian, N., Clarkson, M. W., Zhang, D. D., Horton, N. C., Gunatilaka, A. A. L., Fromme, R. & Chapman, E., Jan 12 2023, In: Journal of Medicinal Chemistry. 66, 1, p. 913-933 21 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
High-Resolution Structure of the Nuclease Domain of the Human Parvovirus B19 Main Replication Protein NS1
Sanchez, J. L., Ghadirian, N. & Horton, N. C., May 2022, In: Journal of virology. 96, 9Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Pretransition state and apo structures of the filamentforming enzyme SgrAI elucidate mechanisms of activation and substrate specificity
Shan, Z., Ghadirian, N., Lyumkis, D. & Horton, N. C., Apr 1 2022, In: Journal of Biological Chemistry. 298, 4, 101760.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
The role of filamentation in activation and DNA sequence specificity of the sequence-specific endonuclease SgrAI
Lyumkis, D. & Horton, N. C., Dec 2022, In: Biochemical Society transactions. 50, 6, p. 1703-1714 12 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations
Datasets
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4C3G : cryo-EM structure of activated and oligomeric restriction endonuclease SgrAI
Lyumkis, D. (Contributor), Talley, H. (Contributor), Stewart, A. (Contributor), Shah, S. (Contributor), Park, C. K. (Contributor), Tama, F. (Contributor), Potter, C. S. (Contributor), Carragher, B. (Contributor) & Horton, N. C. (Contributor), RCSB-PDB, 2013
DOI: 10.2210/pdb4c3g/pdb, https://www.rcsb.org/structure/4C3G
Dataset
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1XHV : HincII bound to cleaved cognate DNA GTCGAC and Mn2+
Etzkorn, C. (Contributor) & Horton, N. C. (Contributor), RCSB-PDB, 2004
DOI: 10.2210/pdb1xhv/pdb, https://www.rcsb.org/structure/1XHV
Dataset
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3EBC : Structure of N141A HincII with Cognate DNA
Little, E. J. (Contributor), Babic, A. C. (Contributor) & Horton, N. C. (Contributor), RCSB-PDB, 2008
DOI: 10.2210/pdb3ebc/pdb, https://www.rcsb.org/structure/3EBC
Dataset
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2AUD : Unliganded HincII
Little, E. J. (Contributor) & Horton, N. C. (Contributor), RCSB-PDB, 2005
DOI: 10.2210/pdb2aud/pdb, https://www.rcsb.org/structure/2AUD
Dataset
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1TW8 : HincII bound to Ca2+ and cognate DNA GTCGAC
Horton, N. C. (Contributor) & Etzkorn, C. (Contributor), RCSB-PDB, 2004
DOI: 10.2210/pdb1tw8/pdb, https://www.rcsb.org/structure/1TW8
Dataset