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Collaborations and top research areas from the last five years
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STRUCTURE BASED APPROACH TO ISSUES IN ZINC FINGER RECOGNITION
Horton, N. C. (PI)
Project: Research project
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STRUCTURAL MECHANISMS OF DNA RECOGNITION AND CLEAVAGE BY SEQUENCE SPECIFIC DNA B
Horton, N. C. (PI)
Project: Research project
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BUDDING YEAST SEPTIN FILAMENTS: CONFORMATION AND KINETICS OF FILAMENT FORMATION
Horton, N. C. (PI)
Project: Research project
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STRUCTURAL MECHANISMS OF DNA RECOGNITION AND CLEAVAGE BY SEQUENCE SPECIFIC DNA B
Horton, N. C. (PI)
Project: Research project
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Crosstalk between co-assembling filamentous enzymes
Horton, N., Aug 2024, In: BioEssays. 46, 8, 2400129.Research output: Contribution to journal › Article › peer-review
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DNA Sequence Control of Enzyme Filamentation and Activation of the SgrAI Endonuclease
Ghadirian, N., Morgan, R. D. & Horton, N. C., Feb 6 2024, In: Biochemistry. 63, 3, p. 326-338 13 p.Research output: Contribution to journal › Article › peer-review
2 Link opens in a new tab Scopus citations -
Structures, mechanisms, and kinetic advantages of the SgrAI filament forming mechanism
Horton, N. C. & Lyumkis, D., 2024, In: Critical reviews in biochemistry and molecular biology. 59, 6, p. 363-401 39 p.Research output: Contribution to journal › Review article › peer-review
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Two-metal ion mechanism of DNA cleavage by activated, filamentous SgrAI
Shan, Z., Rivero-Gamez, A., Lyumkis, D. & Horton, N. C., Aug 2024, In: Journal of Biological Chemistry. 300, 8, 107576.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Physachenolide C is a Potent, Selective BET Inhibitor
Zerio, C. J., Sivinski, J., Wijeratne, E. M. K., Xu, Y. M., Ngo, D. T., Ambrose, A. J., Villa-Celis, L., Ghadirian, N., Clarkson, M. W., Zhang, D. D., Horton, N. C., Gunatilaka, A. A. L., Fromme, R. & Chapman, E., Jan 12 2023, In: Journal of Medicinal Chemistry. 66, 1, p. 913-933 21 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Link opens in a new tab Scopus citations
Datasets
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2I13 : Aart, a six finger zinc finger designed to recognize ANN triplets
Barbas, C. F. (Contributor), Segal, D. J. (Contributor), Crotty, J. W. (Contributor), Bhakta, M. S. (Contributor) & Horton, N. C. (Contributor), RCSB-PDB, 2006
DOI: 10.2210/pdb2i13/pdb, https://www.rcsb.org/structure/2I13
Dataset
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1STX : Structure of the K38A mutant of EcoRV bound to cognate DNA and Mn2+
Horton, N. C. (Contributor) & Perona, J. J. (Contributor), RCSB-PDB, 2004
DOI: 10.2210/pdb1stx/pdb, https://www.rcsb.org/structure/1STX
Dataset
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3N78 : SgrAI bound to Secondary Site DNA and Mg(II)
Little, E. J. (Contributor), Dunten, P. W. (Contributor) & Horton, N. C. (Contributor), RCSB-PDB, 2010
DOI: 10.2210/pdb3n78/pdb, https://www.rcsb.org/structure/3N78
Dataset
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2GIJ : Q138F HincII bound to cognate DNA GTTAAC and Ca2+
Horton, N. C. (Contributor) & Joshi, H. K. (Contributor), RCSB-PDB, 2006
DOI: 10.2210/pdb2gij/pdb, https://www.rcsb.org/structure/2GIJ
Dataset
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3EBC : Structure of N141A HincII with Cognate DNA
Little, E. J. (Contributor), Babic, A. C. (Contributor) & Horton, N. C. (Contributor), RCSB-PDB, 2008
DOI: 10.2210/pdb3ebc/pdb, https://www.rcsb.org/structure/3EBC
Dataset