Keyphrases
RhoA
100%
Structural Biology
100%
GRK6
68%
Glioblastoma multiforme
43%
Rho Guanine nucleotide Exchange Factor
37%
Mayo Clinic
31%
Multiple Myeloma
31%
RhoA Signaling
25%
Project 8
25%
Structure-guided
25%
Postdoctoral Scholars
25%
High-risk Myeloma
18%
PH Domain
18%
Signaling Axis
18%
Therapeutic Targeting
18%
Human Glioma
18%
Lead Generation
12%
Temozolomide
12%
Kinase Target
12%
Lead Optimization
12%
Hematologic
12%
Targeted Therapeutics
12%
High-throughput Assay
12%
Cell Division
12%
Cell Migration
12%
Guided Discovery
12%
Glioma Cells
12%
Cell Growth
12%
Standard-of-care Therapy
12%
Specific Intent
12%
Tumor-related Mortality
6%
Clinical Status
6%
Cyclin-dependent Kinase 5 (Cdk5)
6%
Pro-tumorigenic
6%
Kinase Assay
6%
Invasion Potential
6%
Binding Characterization
6%
Cellular Permeability
6%
In Vitro-in Vivo
6%
GEF Trio
6%
Inhibitor Binding
6%
Rapid Progression
6%
Glioblastoma multiforme Cells
6%
N-terminal Region
6%
P-loop
6%
Virtual Compound Libraries
6%
RhoA Activity
6%
Egg Morphology
6%
Growth Potential
6%
In Vitro Activity
6%
Cell Polarity
6%
Scaffold Hopping
6%
Patient Cells
6%
Malignant Glioma
6%
Hit-to-lead
6%
Cell Movement
6%
Library Screen
6%
DH Domain
6%
PLEKHG5
6%
U87 Glioma Cells
6%
Loop Configuration
6%
U251 Glioma Cell
6%
CNS Tumors
6%
Normal Brain Tissues
6%
Animal Survival
6%
Chemotherapeutic Treatment
6%
Intramolecular Interactions
6%
Suppressing Cell
6%
Enhanced Growth
6%
Hinge Region
6%
Adnectin
6%
Human Tumors
6%
Therapeutic Index
6%
Human Glioma Cells
6%
Crumbs
6%
Hypogammaglobulinemia
6%
Metastatic Potential
6%
RNA Interference Screen
6%
Rho GTPases
6%
Directed Cell Migration
6%
C-terminal Region
6%
Polarity Complexes
6%
Tumor Margin
6%
TIAM1
6%
Pharmacophore
6%
Docking Site
6%
High-level Expression
6%
Experimental Structure
6%
Management Support
6%
Incomplete Knowledge
6%
Functional Genomics
6%
Project Budget
6%
Project Management
6%
Rac1
6%
G Protein-coupled Receptor
6%
Cell Permeable
6%
Binding Affinity
6%
Conventional Chemotherapy
6%
Model Cell
6%
Synergize
6%
Leader Cells
6%
Project Schedule
6%
Extracellular Matrix
6%
Human Cancer
6%
Cellular Models
6%
Ligand Binding
6%
Development pipeline
6%
Statement of Work
6%
Potent Inhibitor
6%
Aggressive Growth
6%
N-terminal Domain
6%
Virtual Screening
6%
Petra
6%
Project Scope
6%
Oncology
6%
Radiation Therapy
6%
Tumor
6%
Cancer Cells
6%
Exchange Factor
6%
Application Requirements
6%
Tractability
6%
Clinical Model
6%
Clinical Outcomes
6%
Catalytic Domain
6%
Proposed Work
6%
Grant Applications
6%
Therapeutic Target
6%
Cell-to-cell
6%
Diverse Groups
6%
Clinical Development
6%
Small Molecule Libraries
6%
Targets of Interest
6%
Rapid Growth
6%
Small Molecule Inhibitors
6%
Druggable Targets
6%
New Drug Targets
6%
IC50
6%
Knock-in Mouse Model
6%
Structural Coverage
6%
Research Advancement
6%
Murine Model
6%
Breast Cancer
6%
Specific Interactions
6%
Co-crystallization
6%
Xenograft Mouse Model
6%
Mechanism of Action
6%
Tumor Cells
6%
Mutation Analysis
6%
Rational Design
6%
Program Research
6%
Cell Edge
6%
Cell-free
6%
Human Glioblastoma
6%
Human Epithelial Cells
6%
Successful Completion
6%
Apoptosis
6%
Stall
6%
Gross Total Resection
6%
In Cancer
6%
Medicine and Dentistry
Glioblastoma
100%
Multiple Myeloma
88%
Rho Guanine Nucleotide Exchange Factor
66%
Glioma Cell
44%
Pleckstrin Homology Domain
33%
Neoplasm
33%
Amino Terminal Sequence
33%
Ganglioglioma
33%
Cell Migration
33%
Phosphotransferase
33%
Temozolomide
22%
Chemotherapy
22%
Carboxy Terminal Sequence
22%
Cell Division
22%
Cell Growth
22%
Malignant Neoplasm
22%
In Vitro
22%
Molecular Library
11%
Metastasis Potential
11%
Central Nervous System Tumor
11%
Cellular Model
11%
Nucleotide
11%
Hypogammaglobulinemia
11%
Cyclic AMP Dependent Protein Kinase
11%
Hinge Region
11%
Cell Polarity
11%
Cell Motion
11%
U87
11%
Enzyme Active Site
11%
Ligand Binding
11%
Rho Guanine Nucleotide Binding Protein
11%
Pharmacophore
11%
Cancer Cell
11%
Mental Capacity
11%
RNA Interference
11%
Brain Tissue
11%
Oncology
11%
IC50
11%
Programmed Cell Death
11%
Binding Affinity
11%
Virtual Screening
11%
Therapeutic Window
11%
N (5 Benzamido 4 Oxo 6 Phenylhexanoyl)proline
11%
Xenograft
11%
Breast Cancer
11%
Epithelial Cell
11%
Lifespan
11%
G Protein Coupled Receptor
11%
Functional Genomics
11%
Extracellular Matrix
11%
Tumor Cell
11%
Surgery
11%
Biochemistry, Genetics and Molecular Biology
GRK6
100%
Guanine Nucleotide Exchange Factor
54%
Pleckstrin Homology Domain
27%
Phosphotransferase
27%
Kinase
27%
Cell Migration
27%
N-Terminus
27%
Cell Division
18%
C-Terminus
18%
Crystal Structure
18%
Cell Growth
18%
Enzyme Active Site
9%
Functional Genomics
9%
Ligand Binding
9%
Mental Capacity
9%
Hinge Region
9%
Pharmacophore
9%
Cell Polarity
9%
Nucleotide
9%
Knockout Mouse
9%
RNA Interference
9%
Cell Movement
9%
Molecular Library
9%
Cancer Cell
9%
IC50
9%
Protein Kinase A
9%
Murine
9%
U87
9%
G Protein Coupled Receptor
9%
Lifespan
9%
Small Molecule
9%
Mouse Model
9%
Binding Affinity
9%