Grant Details
Description
DESCRIPTION (Provided by Applicant): One of the greatest challenges to
successful treatment of cancers lies in early detection and staging. A novel
imaging device is proposed to allow rapid, high quality imaging of the bladder
and other endoscopically accessible organs. This instrument will be based on
the principles of optical coherence tomography (OCT) to achieve micron-scale
resolution over an imaging depth of up to several millimeters. Preliminary
studies have shown that OCT can distinguish normal and cancerous bladder
tissue. The proposed parallel optical coherence tomography (IIOCT) device
represents a fundamental advance over existing OCT systems because it
implements a parallel imaging approach with integrated arrays of optoelectronic
sources, detectors, and specialized micro electronic processing and control
systems. This allows rapid image acquisition (30 frames per second or greater)
with inexpensive, low power light sources. The emitted and detected light is
carried through a small (2mm) fiber bundle, eliminating the need for mechanical
scanning at the distal end of the probe.
A reduction in imaging system size and cost will be realized. The proposed
design utilizes semiconductor manufacturing techniques to condense
electro-optical and signal processing stages on a specialized microchip, which
could be mass produced. Thus, the entire OCT system could potentially be housed
in a small, lightweight box with a detachable probe. An inexpensive, portable
system would allow greater patient access to this diagnostic modality. The
specific aims of this proposal are:
1. Design and fabricate special optoelectronic and optical components for a OCT
system. The considerable optoelectronic expertise and fabrication facilities at
the University of Arizona will be recruited to create the sources, detectors,
and signal processing electronics needed for this effort.
2. Fabricate electronics and integrate components into a miniaturized package.
Optoelectronic and optical components will be integrated with the multi-fiber
bundles used in the interferometer and endoscopic probe.
3. Assemble and test two II OCT Systems. A 10 parallel channel system will be
created and interface software written. Feedback on probe design and user
interface will be sought during animal and human studies and incorporated into
the final, 100 parallel channel system.
4. Determine the ability of the I I OCT system to accurately determine the
stage of transitional cell carcinoma of the bladder. A series of studies will
be performed to determine the value of OCT in distinguishing between normal
bladder tissue, carcinoma in situ (Tis), and cancer confined to mucosa (Ta)
lamina propria (Ti) and muscle (T2).
successful treatment of cancers lies in early detection and staging. A novel
imaging device is proposed to allow rapid, high quality imaging of the bladder
and other endoscopically accessible organs. This instrument will be based on
the principles of optical coherence tomography (OCT) to achieve micron-scale
resolution over an imaging depth of up to several millimeters. Preliminary
studies have shown that OCT can distinguish normal and cancerous bladder
tissue. The proposed parallel optical coherence tomography (IIOCT) device
represents a fundamental advance over existing OCT systems because it
implements a parallel imaging approach with integrated arrays of optoelectronic
sources, detectors, and specialized micro electronic processing and control
systems. This allows rapid image acquisition (30 frames per second or greater)
with inexpensive, low power light sources. The emitted and detected light is
carried through a small (2mm) fiber bundle, eliminating the need for mechanical
scanning at the distal end of the probe.
A reduction in imaging system size and cost will be realized. The proposed
design utilizes semiconductor manufacturing techniques to condense
electro-optical and signal processing stages on a specialized microchip, which
could be mass produced. Thus, the entire OCT system could potentially be housed
in a small, lightweight box with a detachable probe. An inexpensive, portable
system would allow greater patient access to this diagnostic modality. The
specific aims of this proposal are:
1. Design and fabricate special optoelectronic and optical components for a OCT
system. The considerable optoelectronic expertise and fabrication facilities at
the University of Arizona will be recruited to create the sources, detectors,
and signal processing electronics needed for this effort.
2. Fabricate electronics and integrate components into a miniaturized package.
Optoelectronic and optical components will be integrated with the multi-fiber
bundles used in the interferometer and endoscopic probe.
3. Assemble and test two II OCT Systems. A 10 parallel channel system will be
created and interface software written. Feedback on probe design and user
interface will be sought during animal and human studies and incorporated into
the final, 100 parallel channel system.
4. Determine the ability of the I I OCT system to accurately determine the
stage of transitional cell carcinoma of the bladder. A series of studies will
be performed to determine the value of OCT in distinguishing between normal
bladder tissue, carcinoma in situ (Tis), and cancer confined to mucosa (Ta)
lamina propria (Ti) and muscle (T2).
| Status | Finished |
|---|---|
| Effective start/end date | 9/30/02 → 2/28/07 |
Funding
- National Institutes of Health: $305,801.00
- National Institutes of Health: $332,603.00
- National Institutes of Health: $296,891.00
ASJC
- Engineering(all)
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
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