TY - GEN
T1 - A comparison of probe geometries for neuronal localization
AU - Greene, Patrick
AU - Lin, Kevin K.
N1 - Funding Information: ACKNOWLEDGMENT PG was supported in part by NIH Grant T32 GM084905. KL was supported in part by NSF grants DMS-1418775 and DMS-1821286. Publisher Copyright: © 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - Extracellular electrical recordings capture the spiking activity of multiple neurons in the vicinity of a probe. Typically, the features of interest in these recordings are action potentials and their timing. However, for planar probes that span tens or hundreds of neurons, it is possible to identify relative spatial locations of neurons. Such spatial information may be useful for reconstructing local network structure or for improving the quality of spike sorting. We propose a Bayesian modification of a dipole-based method for estimating neural positions from waveforms recorded on multi contact probes and investigate how sensitive it is to prior knowledge about the equivalent dipole sizes of neurons and the geometry of the recording probe. In addition, we determine the probe spacing and number of contacts which produce optimal localization accuracy within the class of planar, circularly symmetric contact configurations.
AB - Extracellular electrical recordings capture the spiking activity of multiple neurons in the vicinity of a probe. Typically, the features of interest in these recordings are action potentials and their timing. However, for planar probes that span tens or hundreds of neurons, it is possible to identify relative spatial locations of neurons. Such spatial information may be useful for reconstructing local network structure or for improving the quality of spike sorting. We propose a Bayesian modification of a dipole-based method for estimating neural positions from waveforms recorded on multi contact probes and investigate how sensitive it is to prior knowledge about the equivalent dipole sizes of neurons and the geometry of the recording probe. In addition, we determine the probe spacing and number of contacts which produce optimal localization accuracy within the class of planar, circularly symmetric contact configurations.
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U2 - https://doi.org/10.1109/EMBC48229.2022.9871756
DO - https://doi.org/10.1109/EMBC48229.2022.9871756
M3 - Conference contribution
C2 - 36086370
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 4083
EP - 4087
BT - 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022
Y2 - 1 January 2022
ER -