A compendium of gene expression in normal human tissues

Li Li Hsiao; Fernando Dangond; Takumi Yoshida; Robert Hong; Roderick V. Jensen; Jatin Misra; William Dillon; Kailin F. Lee; Kathryn E. Clark; Peter Haverty; Zhiping Weng; George L. Mutter; Matthew P. Frosch; Marcy E. MacDonald; Edgar L. Milford; Christopher P. Crum; Raphael Bueno; Richard E. Pratt; Mamatha Mahadevappa; Janet A. Warrington; Gregory Stephanopoulos; George Stephanopoulos; Steven R. Gullans

A compendium of gene expression in normal human tissues

Li Li Hsiao, Fernando Dangond, Takumi Yoshida, Robert Hong, Roderick V. Jensen, Jatin Misra, William Dillon, Kailin F. Lee, Kathryn E. Clark, Peter Haverty, Zhiping Weng, George L. Mutter, Matthew P. Frosch, Marcy E. MacDonald, Edgar L. Milford, Christopher P. Crum, Raphael Bueno, Richard E. Pratt, Mamatha Mahadevappa, Janet A. WarringtonGregory Stephanopoulos, George Stephanopoulos, Steven R. Gullans

Research output: Contribution to journal › Article › peer-review

352 Scopus citations

Abstract

This study creates a compendium of gene expression in normal human tissues suitable as a reference for defining basic organ systems biology. Using oligonucleotide microarrays, we analyze 59 samples representing 19 distinct tissue types. Of ∼7,000 genes analyzed, 451 genes are expressed in all tissue types and designated as housekeeping genes. These genes display significant variation in expression levels among tissues and are sufficient for discerning tissue-specific expression signatures, indicative of fundamental differences in biochemical 'processes. In addition, subsets of tissue-selective genes are identified that define key biological processes characterizing each organ. This compendium high-lights similarities and differences among organ systems and different individuals and also provides a publicly available resource (Human Gene Expression Index, the HuGE Index, http://www.hugeindex.org) for future studies of pathophysiology.

Original language	English (US)
Pages (from-to)	97-104
Number of pages	8
Journal	Physiological genomics
Volume	2002
Issue number	7
State	Published - Jan 1 2002
Externally published	Yes

Keywords

Bioinformatics
Gene expression
Human tissues
Microarrays

ASJC Scopus subject areas

Physiology
Genetics

Cite this

Hsiao, L. L., Dangond, F., Yoshida, T., Hong, R., Jensen, R. V., Misra, J., Dillon, W., Lee, K. F., Clark, K. E., Haverty, P., Weng, Z., Mutter, G. L., Frosch, M. P., MacDonald, M. E., Milford, E. L., Crum, C. P., Bueno, R., Pratt, R. E., Mahadevappa, M., ... Gullans, S. R. (2002). A compendium of gene expression in normal human tissues. Physiological genomics, 2002(7), 97-104.

Hsiao, LL, Dangond, F, Yoshida, T, Hong, R, Jensen, RV, Misra, J, Dillon, W, Lee, KF, Clark, KE, Haverty, P, Weng, Z, Mutter, GL, Frosch, MP, MacDonald, ME, Milford, EL, Crum, CP, Bueno, R, Pratt, RE, Mahadevappa, M, Warrington, JA, Stephanopoulos, G , Stephanopoulos, G & Gullans, SR 2002, 'A compendium of gene expression in normal human tissues', Physiological genomics, vol. 2002, no. 7, pp. 97-104.

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AU - Crum, Christopher P.

AU - Bueno, Raphael

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A compendium of gene expression in normal human tissues

Abstract

Keywords

ASJC Scopus subject areas

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