TY - JOUR
T1 - A hybrid model of a genetic regulatory network in mammalian sclera
AU - Shu, Qin
AU - Ardila, Diana Catalina
AU - Sanfelice, Ricardo G.
AU - Vande Geest, Jonathan P.
N1 - Publisher Copyright: © Q. Shu, D. C. Ardila, R. G. Sanfelice, and J. P. Vande Geest.
PY - 2013/8/27
Y1 - 2013/8/27
N2 - Myopia in human and animals is caused by the axial elongation of the eye and is closely linked to the thinning of the sclera which supports the eye tissue. This thinning has been correlated with the overproduction of matrix metalloproteinase (MMP-2), an enzyme that degrades the collagen structure of the sclera. In this short paper, we propose a descriptive model of a regulatory network with hysteresis, which seems necessary for creating oscillatory behavior in the hybrid model between MMP-2, MT1-MMP and TIMP-2. Numerical results provide insight on the type of equilibria present in the system.
AB - Myopia in human and animals is caused by the axial elongation of the eye and is closely linked to the thinning of the sclera which supports the eye tissue. This thinning has been correlated with the overproduction of matrix metalloproteinase (MMP-2), an enzyme that degrades the collagen structure of the sclera. In this short paper, we propose a descriptive model of a regulatory network with hysteresis, which seems necessary for creating oscillatory behavior in the hybrid model between MMP-2, MT1-MMP and TIMP-2. Numerical results provide insight on the type of equilibria present in the system.
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U2 - 10.4204/EPTCS.125.8
DO - 10.4204/EPTCS.125.8
M3 - Conference article
SN - 2075-2180
VL - 125
SP - 99
EP - 105
JO - Electronic Proceedings in Theoretical Computer Science, EPTCS
JF - Electronic Proceedings in Theoretical Computer Science, EPTCS
T2 - 2nd International Workshop on Hybrid Systems and Biology, HSB 2013
Y2 - 2 September 2013
ER -