A model of regional ventilation-perfusion inhomogeneity in the avian lung. Implications for gas exchange and intrapulmonary chemoreceptor microenvironment

S. C. Hempleman; T. P. Adamson; R. E. Burger

doi:10.1016/0010-468X(83)90021-1

A model of regional ventilation-perfusion inhomogeneity in the avian lung. Implications for gas exchange and intrapulmonary chemoreceptor microenvironment

S. C. Hempleman, T. P. Adamson, R. E. Burger

Biological Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We recorded discharge frequencies of 32 intrapulmonary chemoreceptors (IPC) during caudocranial and craniocaudal ventilation in the perfused duck lung. Blood gases, ventilatory gas flow, inspired P_CO₂ and P_O₂, and expired P_CO₂ measured simultaneously were used to predict regional CO₂ and O₂ gradients within the lung. Gas exchange was modelled in 7 log normal ventilation-perfusion compartments using mass balance differentials with an adjustable step size. CO₂ and O₂ interactions during exchange were modelled using the Bohr effect. P₅₀, blood acid-base status and the CO₂ dissociation relationship. Close agreement (± 1.0 Torr) between simulated arterial and expired P_CO₂ and observed values was achieved after forcing simulated Pa_O₂ to converge on observed Pa_O₂ by an iterative adjustment of the perfusive shunt or the log standard deviation of the ventilation-perfusion distribution. Using the IPC static CO₂ sensitivity measured in the non-perfused lung and the CO₂ gradients generated by the model, we have found evidence for a distributed multi-ending receptor system in the duck lung.

Original language	English (US)
Pages (from-to)	11-18
Number of pages	8
Journal	Computer Programs in Biomedicine
Volume	17
Issue number	1-2
DOIs	https://doi.org/10.1016/0010-468X(83)90021-1
State	Published - 1983

Keywords

Control
Receptive field
Respiration, avian
Simulation, computer

ASJC Scopus subject areas

Medicine (miscellaneous)

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10.1016/0010-468X(83)90021-1

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title = "A model of regional ventilation-perfusion inhomogeneity in the avian lung. Implications for gas exchange and intrapulmonary chemoreceptor microenvironment",

abstract = "We recorded discharge frequencies of 32 intrapulmonary chemoreceptors (IPC) during caudocranial and craniocaudal ventilation in the perfused duck lung. Blood gases, ventilatory gas flow, inspired PCO2 and PO2, and expired PCO2 measured simultaneously were used to predict regional CO2 and O2 gradients within the lung. Gas exchange was modelled in 7 log normal ventilation-perfusion compartments using mass balance differentials with an adjustable step size. CO2 and O2 interactions during exchange were modelled using the Bohr effect. P50, blood acid-base status and the CO2 dissociation relationship. Close agreement (± 1.0 Torr) between simulated arterial and expired PCO2 and observed values was achieved after forcing simulated PaO2 to converge on observed PaO2 by an iterative adjustment of the perfusive shunt or the log standard deviation of the ventilation-perfusion distribution. Using the IPC static CO2 sensitivity measured in the non-perfused lung and the CO2 gradients generated by the model, we have found evidence for a distributed multi-ending receptor system in the duck lung.",

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year = "1983",

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AU - Hempleman, S. C.

AU - Adamson, T. P.

AU - Burger, R. E.

PY - 1983

Y1 - 1983

N2 - We recorded discharge frequencies of 32 intrapulmonary chemoreceptors (IPC) during caudocranial and craniocaudal ventilation in the perfused duck lung. Blood gases, ventilatory gas flow, inspired PCO2 and PO2, and expired PCO2 measured simultaneously were used to predict regional CO2 and O2 gradients within the lung. Gas exchange was modelled in 7 log normal ventilation-perfusion compartments using mass balance differentials with an adjustable step size. CO2 and O2 interactions during exchange were modelled using the Bohr effect. P50, blood acid-base status and the CO2 dissociation relationship. Close agreement (± 1.0 Torr) between simulated arterial and expired PCO2 and observed values was achieved after forcing simulated PaO2 to converge on observed PaO2 by an iterative adjustment of the perfusive shunt or the log standard deviation of the ventilation-perfusion distribution. Using the IPC static CO2 sensitivity measured in the non-perfused lung and the CO2 gradients generated by the model, we have found evidence for a distributed multi-ending receptor system in the duck lung.

AB - We recorded discharge frequencies of 32 intrapulmonary chemoreceptors (IPC) during caudocranial and craniocaudal ventilation in the perfused duck lung. Blood gases, ventilatory gas flow, inspired PCO2 and PO2, and expired PCO2 measured simultaneously were used to predict regional CO2 and O2 gradients within the lung. Gas exchange was modelled in 7 log normal ventilation-perfusion compartments using mass balance differentials with an adjustable step size. CO2 and O2 interactions during exchange were modelled using the Bohr effect. P50, blood acid-base status and the CO2 dissociation relationship. Close agreement (± 1.0 Torr) between simulated arterial and expired PCO2 and observed values was achieved after forcing simulated PaO2 to converge on observed PaO2 by an iterative adjustment of the perfusive shunt or the log standard deviation of the ventilation-perfusion distribution. Using the IPC static CO2 sensitivity measured in the non-perfused lung and the CO2 gradients generated by the model, we have found evidence for a distributed multi-ending receptor system in the duck lung.

KW - Control

KW - Receptive field

KW - Respiration, avian

KW - Simulation, computer

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A model of regional ventilation-perfusion inhomogeneity in the avian lung. Implications for gas exchange and intrapulmonary chemoreceptor microenvironment

Abstract

Keywords

ASJC Scopus subject areas

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