A synergistic approach for neural repair: Cell transplantation and induction of endogenous precursor cell activity

Lalitha Madhavan; Timothy J. Collier

doi:10.1016/j.neuropharm.2009.10.005

A synergistic approach for neural repair: Cell transplantation and induction of endogenous precursor cell activity

Lalitha Madhavan, Timothy J. Collier

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Stem cell research offers enormous potential for treating many diseases of the nervous system. At present, therapeutic strategies in stem cell research segregate into two approaches: cell transplantation or endogenous cell stimulation. Realistically, future cell therapies will most likely involve a combination of these two approaches, a theme of our current research. Here, we propose that there exists a 'synergy' between exogenous (transplanted) and endogenous stem cell actions that can be utilized to achieve therapeutic ends. Elucidating mechanisms underlying this exogenous-endogenous stem cell synergism may lead to the development of optimal cell therapies for neural disorders.

Original language	English (US)
Pages (from-to)	835-844
Number of pages	10
Journal	Neuropharmacology
Volume	58
Issue number	6
DOIs	https://doi.org/10.1016/j.neuropharm.2009.10.005
State	Published - May 2010

Keywords

Growth factors
Neurodegeneration
Neurogenesis
Neuroprotection
Stem cells
Transplantation

ASJC Scopus subject areas

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/j.neuropharm.2009.10.005

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title = "A synergistic approach for neural repair: Cell transplantation and induction of endogenous precursor cell activity",

abstract = "Stem cell research offers enormous potential for treating many diseases of the nervous system. At present, therapeutic strategies in stem cell research segregate into two approaches: cell transplantation or endogenous cell stimulation. Realistically, future cell therapies will most likely involve a combination of these two approaches, a theme of our current research. Here, we propose that there exists a 'synergy' between exogenous (transplanted) and endogenous stem cell actions that can be utilized to achieve therapeutic ends. Elucidating mechanisms underlying this exogenous-endogenous stem cell synergism may lead to the development of optimal cell therapies for neural disorders.",

keywords = "Growth factors, Neurodegeneration, Neurogenesis, Neuroprotection, Stem cells, Transplantation",

author = "Lalitha Madhavan and Collier, {Timothy J.}",

note = "Funding Information: We thank Itzhak Fischer, Masato Nakafuku, Kathy Steece Collier, Caryl Sortwell, Brian Daley, Katrina Paumier and Birgit Ehmer for their advice and technical contributions to the Madhavan et al. (2009) study discussed, and apologize to the many authors whose relevant work we have not been able to cite in this short review. Supported by National Institutes of Health (NS055295) and the Gardner Fund at the University of Cincinnati.",

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doi = "10.1016/j.neuropharm.2009.10.005",

language = "English (US)",

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AU - Collier, Timothy J.

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PY - 2010/5

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N2 - Stem cell research offers enormous potential for treating many diseases of the nervous system. At present, therapeutic strategies in stem cell research segregate into two approaches: cell transplantation or endogenous cell stimulation. Realistically, future cell therapies will most likely involve a combination of these two approaches, a theme of our current research. Here, we propose that there exists a 'synergy' between exogenous (transplanted) and endogenous stem cell actions that can be utilized to achieve therapeutic ends. Elucidating mechanisms underlying this exogenous-endogenous stem cell synergism may lead to the development of optimal cell therapies for neural disorders.

AB - Stem cell research offers enormous potential for treating many diseases of the nervous system. At present, therapeutic strategies in stem cell research segregate into two approaches: cell transplantation or endogenous cell stimulation. Realistically, future cell therapies will most likely involve a combination of these two approaches, a theme of our current research. Here, we propose that there exists a 'synergy' between exogenous (transplanted) and endogenous stem cell actions that can be utilized to achieve therapeutic ends. Elucidating mechanisms underlying this exogenous-endogenous stem cell synergism may lead to the development of optimal cell therapies for neural disorders.

KW - Growth factors

KW - Neurodegeneration

KW - Neurogenesis

KW - Neuroprotection

KW - Stem cells

KW - Transplantation

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DO - 10.1016/j.neuropharm.2009.10.005

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A synergistic approach for neural repair: Cell transplantation and induction of endogenous precursor cell activity

Abstract

Keywords

ASJC Scopus subject areas

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