TY - JOUR
T1 - A system calibration and fast iterative reconstruction method for next-generation SPECT imagers
AU - Miller, Brian W.
AU - Van Holen, Roel
AU - Barrett, Harrison H.
AU - Furenlid, Lars R.
N1 - Funding Information: Manuscript received November 29, 2011; revised April 10, 2012; accepted April 25, 2012. Date of publication June 06, 2012; date of current version October 09, 2012. This work was supported by the National Institutes of Health under NIBIB Grant P41-EB002035 and R37-EB000803. The work of R. Van Holen was supported by a postdoctoral fellowship of the Research Foundation Flanders (FWO).
PY - 2012
Y1 - 2012
N2 - Recently, high-resolution gamma cameras have been developed with detectors containing > 10 5-10 5 elements. Single-photon emission computed tomography (SPECT) imagers based on these detectors usually also have a large number of voxel bins and therefore face memory storage issues for the system matrix when performing fast tomographic reconstructions using iterative algorithms. To address these issues, we have developed a method that parameterizes the detector response to a point source and generates the system matrix on the fly during MLEM or OSEM on graphics hardware. The calibration method, interpolation of coefficient data, and reconstruction results are presented in the context of a recently commissioned small-animal SPECT imager, called FastSPECT III.
AB - Recently, high-resolution gamma cameras have been developed with detectors containing > 10 5-10 5 elements. Single-photon emission computed tomography (SPECT) imagers based on these detectors usually also have a large number of voxel bins and therefore face memory storage issues for the system matrix when performing fast tomographic reconstructions using iterative algorithms. To address these issues, we have developed a method that parameterizes the detector response to a point source and generates the system matrix on the fly during MLEM or OSEM on graphics hardware. The calibration method, interpolation of coefficient data, and reconstruction results are presented in the context of a recently commissioned small-animal SPECT imager, called FastSPECT III.
KW - Calibration
KW - Graphics processing units (GPUs)
KW - High-performance computing
KW - Image reconstruction
KW - Ordered-subset expectation maximization (OSEM)
KW - Single-photon emission computed tomography (SPECT)
KW - System matrix
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U2 - 10.1109/TNS.2012.2198243
DO - 10.1109/TNS.2012.2198243
M3 - Article
SN - 0018-9499
VL - 59
SP - 1990
EP - 1996
JO - IEEE Transactions on Nuclear Science
JF - IEEE Transactions on Nuclear Science
IS - 5 PART 1
M1 - 6213168
ER -