Acoustic localization of sub-micron droplets for targeted imaging and therapy

Paul A. Dayton; Shukui Zhao; Hairong Zheng; Reena Zutshi; Pat Schumann; Kim Penrose; Terry O. Matsunaga; Katherine W. Ferrara

doi:10.1109/ULTSYM.2006.146

Acoustic localization of sub-micron droplets for targeted imaging and therapy

Paul A. Dayton, Shukui Zhao, Hairong Zheng, Reena Zutshi, Pat Schumann, Kim Penrose, Terry O. Matsunaga, Katherine W. Ferrara

Medical Imaging

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Sub-micron droplets comprised of lipid stabilized perfluorocarbons have potential applications in therapeutics and targeted ultrasound imaging. Acoustic energy can provide spatial localization of these droplets to enhance targeted adhesion or for site localized therapy. With ultrasound frequencies in the clinical imaging range and acoustic pressures on the order of megaPascals, these droplets translate in the direction of acoustic wave propagation on the order of hundreds of microns per second. The mechanism for this displacement effect is a combination of radiation force and acoustic streaming. In an in-vitro flowing system, acoustic manipulation of targeted droplets increases targeted droplet retention to ligands on the vessel wall. Ultrasound also locally enhances the delivery of sub-micron particles to a cell monolayer.

Original language	English (US)
Title of host publication	2006 IEEE International Ultrasonics Symposium, IUS
Pages	521-524
Number of pages	4
DOIs	https://doi.org/10.1109/ULTSYM.2006.146
State	Published - 2006

Publication series

Name	Proceedings - IEEE Ultrasonics Symposium
Volume	1

Keywords

Radiation force
Streaming
Therapeutics
Ultrasound

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2006.146

Cite this

Dayton, P. A., Zhao, S., Zheng, H., Zutshi, R., Schumann, P., Penrose, K., Matsunaga, T. O., & Ferrara, K. W. (2006). Acoustic localization of sub-micron droplets for targeted imaging and therapy. In 2006 IEEE International Ultrasonics Symposium, IUS (pp. 521-524). Article 4152002 (Proceedings - IEEE Ultrasonics Symposium; Vol. 1). https://doi.org/10.1109/ULTSYM.2006.146

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title = "Acoustic localization of sub-micron droplets for targeted imaging and therapy",

abstract = "Sub-micron droplets comprised of lipid stabilized perfluorocarbons have potential applications in therapeutics and targeted ultrasound imaging. Acoustic energy can provide spatial localization of these droplets to enhance targeted adhesion or for site localized therapy. With ultrasound frequencies in the clinical imaging range and acoustic pressures on the order of megaPascals, these droplets translate in the direction of acoustic wave propagation on the order of hundreds of microns per second. The mechanism for this displacement effect is a combination of radiation force and acoustic streaming. In an in-vitro flowing system, acoustic manipulation of targeted droplets increases targeted droplet retention to ligands on the vessel wall. Ultrasound also locally enhances the delivery of sub-micron particles to a cell monolayer.",

keywords = "Radiation force, Streaming, Therapeutics, Ultrasound",

author = "Dayton, {Paul A.} and Shukui Zhao and Hairong Zheng and Reena Zutshi and Pat Schumann and Kim Penrose and Matsunaga, {Terry O.} and Ferrara, {Katherine W.}",

year = "2006",

doi = "10.1109/ULTSYM.2006.146",

language = "English (US)",

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series = "Proceedings - IEEE Ultrasonics Symposium",

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T1 - Acoustic localization of sub-micron droplets for targeted imaging and therapy

AU - Dayton, Paul A.

AU - Zhao, Shukui

AU - Zheng, Hairong

AU - Zutshi, Reena

AU - Schumann, Pat

AU - Penrose, Kim

AU - Matsunaga, Terry O.

AU - Ferrara, Katherine W.

PY - 2006

Y1 - 2006

N2 - Sub-micron droplets comprised of lipid stabilized perfluorocarbons have potential applications in therapeutics and targeted ultrasound imaging. Acoustic energy can provide spatial localization of these droplets to enhance targeted adhesion or for site localized therapy. With ultrasound frequencies in the clinical imaging range and acoustic pressures on the order of megaPascals, these droplets translate in the direction of acoustic wave propagation on the order of hundreds of microns per second. The mechanism for this displacement effect is a combination of radiation force and acoustic streaming. In an in-vitro flowing system, acoustic manipulation of targeted droplets increases targeted droplet retention to ligands on the vessel wall. Ultrasound also locally enhances the delivery of sub-micron particles to a cell monolayer.

AB - Sub-micron droplets comprised of lipid stabilized perfluorocarbons have potential applications in therapeutics and targeted ultrasound imaging. Acoustic energy can provide spatial localization of these droplets to enhance targeted adhesion or for site localized therapy. With ultrasound frequencies in the clinical imaging range and acoustic pressures on the order of megaPascals, these droplets translate in the direction of acoustic wave propagation on the order of hundreds of microns per second. The mechanism for this displacement effect is a combination of radiation force and acoustic streaming. In an in-vitro flowing system, acoustic manipulation of targeted droplets increases targeted droplet retention to ligands on the vessel wall. Ultrasound also locally enhances the delivery of sub-micron particles to a cell monolayer.

KW - Radiation force

KW - Streaming

KW - Therapeutics

KW - Ultrasound

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UR - http://www.scopus.com/inward/citedby.url?scp=71749104180&partnerID=8YFLogxK

U2 - 10.1109/ULTSYM.2006.146

DO - 10.1109/ULTSYM.2006.146

M3 - Conference contribution

SN - 1424402018

SN - 9781424402014

T3 - Proceedings - IEEE Ultrasonics Symposium

SP - 521

EP - 524

BT - 2006 IEEE International Ultrasonics Symposium, IUS

ER -

Acoustic localization of sub-micron droplets for targeted imaging and therapy

Abstract

Publication series

Keywords

ASJC Scopus subject areas

Access to Document

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