TY - GEN
T1 - Acoustic response of phase change contrast agents targeted with breast cancer cells immediately after ultrasonic activation using ultrafast imaging
AU - Zhang, Ge
AU - Lin, Shengtao
AU - Leow, Chee Hau
AU - Pang, Kuin
AU - Gil, Javier Hernandez
AU - Matsunaga, Terry
AU - Tang, Mengxing
N1 - Funding Information: Ge Zhang1, Shengtao Lin1, Chee Hau Leow1, Kuin Pang1,2, Javier Hernandez Gil3, Terry Matsunaga4, Mengxing Tang1;1Department of Bioengineering, Imperial College London, United Kingdom, 2Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, 3Department of Chemistry, Imperial College London, United Kingdom, 4Department of Medical Imaging, University of Arizona, USA Publisher Copyright: © 2017 IEEE.
PY - 2017/10/31
Y1 - 2017/10/31
N2 - Phase-change contrast agents (PCCAs) have advantageous properties in terms of smaller size, longer half-life and selective activation control compared to conventional microbubble contrast agents (MCAs), which make them ideal for ultrasound cancer imaging. [1] Acoustic signal from tumour site can be further enhanced by receptor targeted PCCAs. However there is still a lack of understanding of the behaviour of these targeted agents. In this work, we report the use of high frame rate (HFR) imaging to investigate the changes in acoustic signal of Folate Receptor (FR)-targeted versus control PCCAs with breast cancer cells immediately after acoustic activation.
AB - Phase-change contrast agents (PCCAs) have advantageous properties in terms of smaller size, longer half-life and selective activation control compared to conventional microbubble contrast agents (MCAs), which make them ideal for ultrasound cancer imaging. [1] Acoustic signal from tumour site can be further enhanced by receptor targeted PCCAs. However there is still a lack of understanding of the behaviour of these targeted agents. In this work, we report the use of high frame rate (HFR) imaging to investigate the changes in acoustic signal of Folate Receptor (FR)-targeted versus control PCCAs with breast cancer cells immediately after acoustic activation.
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U2 - 10.1109/ULTSYM.2017.8091642
DO - 10.1109/ULTSYM.2017.8091642
M3 - Conference contribution
T3 - IEEE International Ultrasonics Symposium, IUS
BT - 2017 IEEE International Ultrasonics Symposium, IUS 2017
PB - IEEE Computer Society
T2 - 2017 IEEE International Ultrasonics Symposium, IUS 2017
Y2 - 6 September 2017 through 9 September 2017
ER -