TY - GEN
T1 - Acoustic response of targeted nanodroplets post-activation using high frame rate imaging
AU - Zhang, Ge
AU - Lin, Shengtao
AU - Leow, Chee Hau
AU - Pang, Kuin
AU - Hernandez-Gil, Javier
AU - Chee, Melisse
AU - Long, Nicholas J.
AU - Matsunaga, Terry O.
AU - Tang, Meng Xing
N1 - Funding Information: ∗Department of Bioengineering, Imperial College London, United Kingdom †Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore ‡Department of Chemistry, Imperial College London, United Kingdom §Department of Materials, Imperial College London, United Kingdom ¶Department of Medical Imaging, University of Arizona, USA ‖Email:[email protected] Publisher Copyright: © 2017 IEEE.
PY - 2017/10/31
Y1 - 2017/10/31
N2 - Targeted phase-change contrast agents (PCCAs) have shown great potential for both cancer imaging and therapy. However the acoustic response of targeted PCCAs exposed to ultrasound high frame rate imaging pulses after vaporization has not been fully explored. We herein report the investigation of the change in acoustic signal of folate receptor targeted (FR)-and non-targeted (NT)-PCCAs exposed to breast cancer cells immediately after acoustic vaporization using high frame rate ultrasound imaging. The results show that the vaporized FR-PCCAs measured on the cells has higher acoustic signal than vaporized NT-PCCAs. Moreover, it was found that the acoustic signal of vaporized FR-PCCA on the cells is more persistent than that of vaporized NT-PCCAs 1 second post activation. This is likely because the FR-PCCAs can be vaporized and remain attached to the cancer cells. Furthermore, the high frame rate ultrasound imaging used in this study showed the fast decay of the acoustic signal on the cells immediately after activation, particularly for the NT-PCCAs. These results offer a new insight into the behavior of targeted PCCAs for ultrasound molecular imaging and therapy.
AB - Targeted phase-change contrast agents (PCCAs) have shown great potential for both cancer imaging and therapy. However the acoustic response of targeted PCCAs exposed to ultrasound high frame rate imaging pulses after vaporization has not been fully explored. We herein report the investigation of the change in acoustic signal of folate receptor targeted (FR)-and non-targeted (NT)-PCCAs exposed to breast cancer cells immediately after acoustic vaporization using high frame rate ultrasound imaging. The results show that the vaporized FR-PCCAs measured on the cells has higher acoustic signal than vaporized NT-PCCAs. Moreover, it was found that the acoustic signal of vaporized FR-PCCA on the cells is more persistent than that of vaporized NT-PCCAs 1 second post activation. This is likely because the FR-PCCAs can be vaporized and remain attached to the cancer cells. Furthermore, the high frame rate ultrasound imaging used in this study showed the fast decay of the acoustic signal on the cells immediately after activation, particularly for the NT-PCCAs. These results offer a new insight into the behavior of targeted PCCAs for ultrasound molecular imaging and therapy.
KW - Acoustic Vaporization
KW - Breast Cancer Cells
KW - Cancer Molecular Imaging
KW - Targeted Phase-Change Contrast Agents
KW - Ultrafast Imaging
UR - http://www.scopus.com/inward/record.url?scp=85039441113&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85039441113&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2017.8092693
DO - 10.1109/ULTSYM.2017.8092693
M3 - Conference contribution
T3 - IEEE International Ultrasonics Symposium, IUS
BT - 2017 IEEE International Ultrasonics Symposium, IUS 2017
PB - IEEE Computer Society
T2 - 2017 IEEE International Ultrasonics Symposium, IUS 2017
Y2 - 6 September 2017 through 9 September 2017
ER -