TY - JOUR
T1 - Activity against Plasmodium falciparum of lactones isolated from the endophytic fungus Xylaria sp.
AU - Jiménez-Romero, Carlos
AU - Ortega-Barría, Eduardo
AU - Arnold, A. Elizabeth
AU - Cubilla-Rios, Luis
N1 - Funding Information: The authors extend special thanks to the Smithsonian Tropical Research Institute and the International Cooperative Biodiversity Groups, ICBG-Panama program (grant number 1 UO1 TWO6634-01), for financial support for this research and the Institute for Advanced Scientific Investigation and Technology Services for NMR services. AEA gratefully acknowledges additional support from NSF DEB-0200413, DEB-0516564, and DEB-0640956. We thank Thomas A. Kursar and Phyllis D. Coley for developing the endophytic fungus program in the ICBG.
PY - 2008/10
Y1 - 2008/10
N2 - Three lactones were isolated from the culture medium of the endophytic fungus Xylaria sp. Grev. (Xylariaceae). The major compound, which showed weak activity (13 μg/mL) against a chloroquine-resistant strain of Plasmodium falciparum, was identified as (+)-phomalactone (1). The others were 6-(1-propenyl)-3,4,5,6-tetrahydro-5-hydroxy-4H-pyran-2-one (2) and 5-hydroxymellein (3). Compounds 1 and 2 are reported for the first time as constituents of Xylaria. Also, this is the first report of the activity of the compounds 1-3 against a chloroquine-resistant Plasmodium falciparum strain.
AB - Three lactones were isolated from the culture medium of the endophytic fungus Xylaria sp. Grev. (Xylariaceae). The major compound, which showed weak activity (13 μg/mL) against a chloroquine-resistant strain of Plasmodium falciparum, was identified as (+)-phomalactone (1). The others were 6-(1-propenyl)-3,4,5,6-tetrahydro-5-hydroxy-4H-pyran-2-one (2) and 5-hydroxymellein (3). Compounds 1 and 2 are reported for the first time as constituents of Xylaria. Also, this is the first report of the activity of the compounds 1-3 against a chloroquine-resistant Plasmodium falciparum strain.
KW - Antiplasmodial
KW - Endophytic fungus
KW - Phomalactone
KW - Plasmodium falciparum
KW - Xylaria sp.
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U2 - 10.1080/13880200802215859
DO - 10.1080/13880200802215859
M3 - Article
SN - 1388-0209
VL - 46
SP - 700
EP - 703
JO - Pharmaceutical Biology
JF - Pharmaceutical Biology
IS - 10-11
ER -