Activity against Plasmodium falciparum of lactones isolated from the endophytic fungus Xylaria sp.

Carlos Jiménez-Romero; Eduardo Ortega-Barría; A. Elizabeth Arnold; Luis Cubilla-Rios

doi:10.1080/13880200802215859

Activity against Plasmodium falciparum of lactones isolated from the endophytic fungus Xylaria sp.

Carlos Jiménez-Romero
, Eduardo Ortega-Barría
, A. Elizabeth Arnold
, Luis Cubilla-Rios

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Three lactones were isolated from the culture medium of the endophytic fungus Xylaria sp. Grev. (Xylariaceae). The major compound, which showed weak activity (13 μg/mL) against a chloroquine-resistant strain of Plasmodium falciparum, was identified as (+)-phomalactone (1). The others were 6-(1-propenyl)-3,4,5,6-tetrahydro-5-hydroxy-4H-pyran-2-one (2) and 5-hydroxymellein (3). Compounds 1 and 2 are reported for the first time as constituents of Xylaria. Also, this is the first report of the activity of the compounds 1-3 against a chloroquine-resistant Plasmodium falciparum strain.

Original language	English (US)
Pages (from-to)	700-703
Number of pages	4
Journal	Pharmaceutical Biology
Volume	46
Issue number	10-11
DOIs	https://doi.org/10.1080/13880200802215859
State	Published - Oct 2008

Keywords

Antiplasmodial
Endophytic fungus
Phomalactone
Plasmodium falciparum
Xylaria sp.

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

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10.1080/13880200802215859

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title = "Activity against Plasmodium falciparum of lactones isolated from the endophytic fungus Xylaria sp.",

abstract = "Three lactones were isolated from the culture medium of the endophytic fungus Xylaria sp. Grev. (Xylariaceae). The major compound, which showed weak activity (13 μg/mL) against a chloroquine-resistant strain of Plasmodium falciparum, was identified as (+)-phomalactone (1). The others were 6-(1-propenyl)-3,4,5,6-tetrahydro-5-hydroxy-4H-pyran-2-one (2) and 5-hydroxymellein (3). Compounds 1 and 2 are reported for the first time as constituents of Xylaria. Also, this is the first report of the activity of the compounds 1-3 against a chloroquine-resistant Plasmodium falciparum strain.",

keywords = "Antiplasmodial, Endophytic fungus, Phomalactone, Plasmodium falciparum, Xylaria sp.",

author = "Carlos Jim{\'e}nez-Romero and Eduardo Ortega-Barr{\'i}a and Arnold, \{A. Elizabeth\} and Luis Cubilla-Rios",

note = "Funding Information: The authors extend special thanks to the Smithsonian Tropical Research Institute and the International Cooperative Biodiversity Groups, ICBG-Panama program (grant number 1 UO1 TWO6634-01), for financial support for this research and the Institute for Advanced Scientific Investigation and Technology Services for NMR services. AEA gratefully acknowledges additional support from NSF DEB-0200413, DEB-0516564, and DEB-0640956. We thank Thomas A. Kursar and Phyllis D. Coley for developing the endophytic fungus program in the ICBG.",

year = "2008",

month = oct,

doi = "10.1080/13880200802215859",

language = "English (US)",

volume = "46",

pages = "700--703",

journal = "Pharmaceutical Biology",

issn = "1388-0209",

publisher = "Informa Healthcare",

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}

TY - JOUR

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AU - Jiménez-Romero, Carlos

AU - Ortega-Barría, Eduardo

AU - Arnold, A. Elizabeth

AU - Cubilla-Rios, Luis

N1 - Funding Information: The authors extend special thanks to the Smithsonian Tropical Research Institute and the International Cooperative Biodiversity Groups, ICBG-Panama program (grant number 1 UO1 TWO6634-01), for financial support for this research and the Institute for Advanced Scientific Investigation and Technology Services for NMR services. AEA gratefully acknowledges additional support from NSF DEB-0200413, DEB-0516564, and DEB-0640956. We thank Thomas A. Kursar and Phyllis D. Coley for developing the endophytic fungus program in the ICBG.

PY - 2008/10

Y1 - 2008/10

N2 - Three lactones were isolated from the culture medium of the endophytic fungus Xylaria sp. Grev. (Xylariaceae). The major compound, which showed weak activity (13 μg/mL) against a chloroquine-resistant strain of Plasmodium falciparum, was identified as (+)-phomalactone (1). The others were 6-(1-propenyl)-3,4,5,6-tetrahydro-5-hydroxy-4H-pyran-2-one (2) and 5-hydroxymellein (3). Compounds 1 and 2 are reported for the first time as constituents of Xylaria. Also, this is the first report of the activity of the compounds 1-3 against a chloroquine-resistant Plasmodium falciparum strain.

AB - Three lactones were isolated from the culture medium of the endophytic fungus Xylaria sp. Grev. (Xylariaceae). The major compound, which showed weak activity (13 μg/mL) against a chloroquine-resistant strain of Plasmodium falciparum, was identified as (+)-phomalactone (1). The others were 6-(1-propenyl)-3,4,5,6-tetrahydro-5-hydroxy-4H-pyran-2-one (2) and 5-hydroxymellein (3). Compounds 1 and 2 are reported for the first time as constituents of Xylaria. Also, this is the first report of the activity of the compounds 1-3 against a chloroquine-resistant Plasmodium falciparum strain.

KW - Antiplasmodial

KW - Endophytic fungus

KW - Phomalactone

KW - Plasmodium falciparum

KW - Xylaria sp.

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M3 - Article

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JF - Pharmaceutical Biology

IS - 10-11

ER -

Activity against Plasmodium falciparum of lactones isolated from the endophytic fungus Xylaria sp.

Abstract

Keywords

ASJC Scopus subject areas

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