TY - JOUR
T1 - Adjuvant chemoimmunotherapy following regional therapy for isolated recurrences of breast cancer (stage IV NED)
AU - Buzdar, Aman U.
AU - Blumenschein, George R.
AU - Smith, Terry L.
AU - Tashima, Charles K.
AU - Hortobagyi, Gabriel N.
AU - Yap, H. Yong
AU - Gutterman, Jordan U.
AU - Hersh, Evan M.
AU - Gehan, Edmund A.
PY - 1979
Y1 - 1979
N2 - A combination of 5‐fluorouracil, Adriamycin, cyclophosphamide, and BCG (FAC‐BCG) was evaluated as adjuvant treatment in breast cancer patients following surgical excision and/or radiation of first site of recurrent disease. In a group of 68 patients treated with FAC‐BCG, the estimated proportion remaining free of disease at 2 years from first recurrence was 69%, compared to 24% in 60 historical control patients (P < 0.01). Estimated 2‐year survival rate from first recurrence was 85% for the FAC‐BCG patients and 78% for the controls (P = 0.07). This regimen has significantly prolonged the disease‐free interval from the first recurrence, but additional follow‐up is needed to determine its effect on long‐term survival.
AB - A combination of 5‐fluorouracil, Adriamycin, cyclophosphamide, and BCG (FAC‐BCG) was evaluated as adjuvant treatment in breast cancer patients following surgical excision and/or radiation of first site of recurrent disease. In a group of 68 patients treated with FAC‐BCG, the estimated proportion remaining free of disease at 2 years from first recurrence was 69%, compared to 24% in 60 historical control patients (P < 0.01). Estimated 2‐year survival rate from first recurrence was 85% for the FAC‐BCG patients and 78% for the controls (P = 0.07). This regimen has significantly prolonged the disease‐free interval from the first recurrence, but additional follow‐up is needed to determine its effect on long‐term survival.
KW - adjuvant chemotherapy
KW - isolated recurrence of breast cancer
UR - https://www.scopus.com/pages/publications/0018370222
UR - https://www.scopus.com/pages/publications/0018370222#tab=citedBy
U2 - 10.1002/jso.2930120105
DO - 10.1002/jso.2930120105
M3 - Article
C2 - 480951
SN - 0022-4790
VL - 12
SP - 27
EP - 40
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 1
ER -