@inbook{914be35a33df45cbb4a4b21c1f76c54d,
title = "Allosteric mechanisms of G protein-coupled receptor signaling: A structural perspective",
abstract = "G protein-Coupled Receptors (GPCRs) use a complex series of intramolecular conformational changes to couple agonist binding to the binding and activation of cognate heterotrimeric G protein (Gαβγ). The mechanisms underlying this long-range activation have been identified using a variety of biochemical and structural approaches and have primarily used visual signal transduction via the GPCR rhodopsin and cognate heterotrimeric G protein transducin (G t) as a model system. In this chapter, we review the methods that have revealed allosteric signaling through rhodopsin and transducin. These methods can be applied to a variety of GPCR-mediated signaling pathways.",
keywords = "G protein-coupled receptor, Heterotrimeric G proteins, Receptor-mediated nucleotide exchange, Rhodopsin, Transducin",
author = "Thaker, \{Tarjani M.\} and Kaya, \{Ali I.\} and Preininger, \{Anita M.\} and Hamm, \{Heidi E.\} and Iverson, \{T. M.\}",
year = "2012",
doi = "10.1007/978-1-61779-334-9\_8",
language = "English (US)",
isbn = "9781617793332",
series = "Methods in Molecular Biology",
pages = "133--174",
editor = "A.W. Fenton",
booktitle = "Allostery",
}