TY - JOUR
T1 - Anaplasma phagocytophilum subverts tick salivary gland proteins
AU - Foley, Janet
AU - Nieto, Nathan
PY - 2007/1
Y1 - 2007/1
N2 - Anaplasma phagocytophilum is a bacterium that is transmitted by Ixodes spp. ticks, in which it resides in salivary glands. Ticks inoculate the pathogen into hosts together with an array of salivary molecules that reduce host anti-tick inflammation. Sukumaran et al. recently showed that A. phagocytophilum uses a tick salivary protein, Salp16, to enhance its uptake from the host and into the salivary gland. Occupation and exploitation of tick salivary glands have implications for the maintenance and detection of A. phagocytophilum in its vector and early pathogen interactions with its hosts.
AB - Anaplasma phagocytophilum is a bacterium that is transmitted by Ixodes spp. ticks, in which it resides in salivary glands. Ticks inoculate the pathogen into hosts together with an array of salivary molecules that reduce host anti-tick inflammation. Sukumaran et al. recently showed that A. phagocytophilum uses a tick salivary protein, Salp16, to enhance its uptake from the host and into the salivary gland. Occupation and exploitation of tick salivary glands have implications for the maintenance and detection of A. phagocytophilum in its vector and early pathogen interactions with its hosts.
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U2 - 10.1016/j.pt.2006.10.003
DO - 10.1016/j.pt.2006.10.003
M3 - Short survey
C2 - 17092773
SN - 1471-4922
VL - 23
SP - 3
EP - 5
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 1
ER -