Anti-tumor activity and mechanism of action for a cyanoaziridine- derivative, AMP423

Keyphrases

• Mechanism of Action 100%
• Antitumor Activity 100%
• Antitumor Effect 100%
• Imexon 100%
• Cancer Cell Lines 50%
• Tumor-bearing Mice 50%
• Myeloma 50%
• SCID Mice 50%
• Cytotoxic Activity 50%
• Non-tumor 50%
• Apoptosis 25%
• Necrosis 25%
• Toxicology 25%
• Tumor 25%
• Myeloma Cells 25%
• Mechanistic Studies 25%
• Xenograft 25%
• Nucleophile 25%
• Pharmacokinetics 25%
• Antitumor Agents 25%
• Cell Death Pathways 25%
• Sigma Phase 25%
• Structural Analogues 25%
• In Vivo Activity 25%
• Carboxamide 25%
• Alkylation 25%
• Protein Synthesis Inhibition 25%
• Sulfhydryl 25%
• Human Lymphoma 25%
• B-cell Lymphoma 25%
• Cell Cycle Arrest 25%
• Tumor Growth Delay 25%
• Naphthyl 25%
• Resistant Variants 25%
• Hematological Cancer 25%
• Pro-oxidant 25%
• Myelosuppression 25%
• Mechanism of Action Studies 25%
• Pro-oxidant Effect 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Neoplasm 100%
• Imexon 66%
• Myeloma 50%
• Malignant Neoplasm 33%
• Oxidizing Agent 33%
• SCID Mouse 33%
• Preclinical Study 16%
• Tumor Growth 16%
• Carboxamide 16%
• Reactive Oxygen Metabolite 16%
• Naphthalene 16%
• Nucleophile 16%
• Necrosis 16%
• Cancer Inhibition 16%
• B Cell Lymphoma 16%
• Thiol Derivative 16%
• Toxicology 16%
• Pharmacokinetics 16%