Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544

Sergio Martińez-Luis; Lilia Cherigo; Elizabeth Arnold; Carmenza Spadafora; William H. Gerwick; Luis Cubilla-Rios

doi:10.1177/1934578x1200700207

Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544

Sergio Martińez-Luis, Lilia Cherigo, Elizabeth Arnold, Carmenza Spadafora, William H. Gerwick, Luis Cubilla-Rios

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

With the combined goal of finding the best anti-parasitic and anti-cancer activities as well as isolating the bioactive agents and studying their structures and biological properties, we proceeded to perform a small-scale cultivation of Aspergillus sp. strain F1544 using Potato Dextrose, Malt Extract, Czapek Dox and Eight Vegetables media. From the more promising extracts (obtaining using potato dextrose and czapek dox media in large scale) of this fungus, we isolated the five compounds: pseurotin A (1), 14-norpseurotin A (2), FD-838 (3), and pseurotin D (4), and fumoquinone B (5). All compounds showed good antileishmanial and moderate anticancer activities.

Original language	English (US)
Pages (from-to)	165-168
Number of pages	4
Journal	Natural Product Communications
Volume	7
Issue number	2
DOIs	https://doi.org/10.1177/1934578x1200700207
State	Published - Feb 2012

Keywords

Aspergillus sp. strain F1544
Fumoquinone
L. donovani
MCF-7
P. falciparum
Pseurotins
T. cruzi

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Complementary and alternative medicine

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10.1177/1934578x1200700207

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abstract = "With the combined goal of finding the best anti-parasitic and anti-cancer activities as well as isolating the bioactive agents and studying their structures and biological properties, we proceeded to perform a small-scale cultivation of Aspergillus sp. strain F1544 using Potato Dextrose, Malt Extract, Czapek Dox and Eight Vegetables media. From the more promising extracts (obtaining using potato dextrose and czapek dox media in large scale) of this fungus, we isolated the five compounds: pseurotin A (1), 14-norpseurotin A (2), FD-838 (3), and pseurotin D (4), and fumoquinone B (5). All compounds showed good antileishmanial and moderate anticancer activities.",

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AU - Cherigo, Lilia

AU - Arnold, Elizabeth

AU - Spadafora, Carmenza

AU - Gerwick, William H.

AU - Cubilla-Rios, Luis

PY - 2012/2

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KW - Aspergillus sp. strain F1544

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Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544

Abstract

Keywords

ASJC Scopus subject areas

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