Association between coronary angiography with or without percutaneous coronary intervention and outcomes after out-of-hospital cardiac arrest

Aim: The aim of our study was to assess the impact of coronary angiography (CAG) after out-of-hospital cardiac arrest (OHCA) without ST-elevation (STE). Methods: Prospective observational study of adult (age ≥ 18) OHCA of presumed cardiac etiology from 1/01/2010–12/31/2014 admitted to one of 40 recognized cardiac receiving centers within a statewide resuscitation network. Results: Among 11,976 cases, 1881 remained for analysis after exclusions. Of the 1230 non-STE cases, 524 (43%) underwent CAG with resultant PCI in 157 (30%). Survival in non-STE cases was: 56% in cases without CAG; 82% in cases with CAG but without PCI; and 78% in those with PCI (p < 0.0001). In cases without STE the aOR for survival with CAG alone was 2.34 (95% CI 1.69–3.24) and for CAG plus PCI was 1.98 (95% CI 1.26–3.09). The aOR for CPC 1/2 with CAG alone was 6.89 (95% CI 3.99–11.91) and for CAG plus PCI was 2.95 (95% CI 1.59–5.47). After propensity matching, CAG was associated with an aOR for survival of 2.10 (95% CI 1.30–3.55) and for CPC 1/2 it was 5.06 (95% CI 2.29–11.19). Conclusion: In OHCA without STE, CAG was strongly and independently associated with survival regardless of whether PCI was performed. The association between CAG and positive outcomes remained after propensity matching.