@article{af919155da0b4c9bb6cdd4b96b309a74,
title = "Association Between Sarcopenic Obesity and Falls in a Multiethnic Cohort of Postmenopausal Women",
abstract = "OBJECTIVES: To investigate associations between sarcopenia, obesity, and sarcopenic obesity and incidence of falls in a racially and ethnically diverse cohort of healthy postmenopausal women. DESIGN: Prospective cohort study. SETTING: Three Women's Health Initiative (WHI) clinical centers (Tucson-Phoenix, AZ; Pittsburgh, PA; Birmingham, AL). PARTICIPANTS: Postmenopausal women aged 50 to 79 enrolled in the WHI who underwent bone and body composition scans using dual-energy x-ray absorptiometry at baseline (N = 11,020). MEASUREMENTS: Sarcopenia was defined as the lowest 20th percentile of appendicular lean mass, correcting for height and body fat. Obesity was defined as a body fat percentage greater than 42%. Sarcopenic obesity was defined as co-occurrence of sarcopenia and obesity. The fall outcome was defined as falling 2 or more times in any year during 7 years of follow-up. The risk of falls associated with sarcopenic obesity were analyzed using log binomial regression models stratified according to age and race/ethnicity. Results: Sarcopenic obesity was associated with greater risk of falls in women aged 50 to 64 (relative risk (RR) = 1.35, 95% confidence interval (CI)=1.17–1.56) and 65 to 79 (RR = 1.21, 95% CI=1.05–1.39). Sarcopenic obesity related fall risk was higher in Hispanic women (RR = 2.40, 95% CI=1.56–3.67) than non-Hispanic white women (RR = 1.24, 95% CI=1.11–1.39). Conclusion: In a multiethnic cohort of postmenopausal women, sarcopenic obesity–related fall risk was high in women younger than 65 and those age 65 and older. Sarcopenic obesity posed the highest risk for falls in Hispanic women. The findings support identification of causal factors and health disparities in sarcopenic obesity to customize fall prevention strategies and ameliorate this significant public health burden. J Am Geriatr Soc 66:2314–2320, 2018.",
keywords = "Women's Health Initiative, falls, obesity, race, sarcopenia",
author = "Shawna Follis and Alan Cook and Bea, {Jennifer W.} and Going, {Scott B.} and Deepika Laddu and Cauley, {Jane A.} and Shadyab, {Aladdin H.} and Stefanick, {Marcia L.} and Zhao Chen",
note = "Funding Information: Financial Disclosure: The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services, through Contracts HHSN268201600018C, HHSN2682016 00001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C. This work was supported by the WHI, which is funded by the National Heart, Lung, and Blood Institute through Contracts HHSN268201100046C, HHSN2 68201100001C, HHSN268201100002C, HHSN268201100 003C, HHSN268201100004C, and HHSN271201100004C. Funding Information: Financial Disclosure: The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services, through Contracts HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C. This work was supported by the WHI, which is funded by the National Heart, Lung, and Blood Institute through Contracts HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C. Program Office: (National Heart, Lung, and Blood Institute, Bethesda, Maryland). Jacques Rossouw, Shari Ludlam, Joan McGowan, Leslie Ford, Nancy Geller. Clinical Coordinating Center: (Fred Hutchinson Cancer Research Center, Seattle, WA). Garnet Anderson, Ross Prentice, Andrea LaCroix, Charles Kooperberg. Investigators and Academic Centers: Brigham and Women's Hospital, Harvard Medical School, Boston, MA: JoAnn E. Manson; MedStar Health Research Institute/Howard University, Washington, DC: Barbara V. Howard; Stanford Prevention Research Center, Stanford, CA: Marcia L. Stefanick; The Ohio State University, Columbus, OH: Rebecca Jackson; University of Arizona, Tucson/Phoenix, AZ: Cynthia A. Thomson; University at Buffalo, Buffalo, NY: Jean Wactawski-Wende; University of Florida, Gainesville/Jacksonville, FL: Marian Limacher; University of Iowa, Iowa City/Davenport, IA: Jennifer Robinson; University of Pittsburgh, Pittsburgh, PA: Lewis Kuller; Wake Forest University School of Medicine, Winston-Salem, NC: Sally Shumaker; University of Nevada, Reno, NV: Robert Brunner; University of Minnesota, Minneapolis, MN: Karen L. Margolis. For a list of all investigators who have contributed to WHI science, see: https://www.whi.org/researchers/Documents%20%20Write%20a%20Paper/WHI%20Investigator%20Long%20List.pdf. Conflict of Interest: None. Author Contributions: Follis, Cook: study concept and design; acquisition, analysis, and interpretation of data; preparation and final approval of manuscript. Bea, Going, Laddu, Shadyab: study design, interpretation of data, preparation and final approval of manuscript. Cauley: study design, data collection, interpretation of data, final approval of manuscript. Stefanick: study design, data collection, final approval of manuscript. Chen: study concept and design, acquisition and interpretation of data, final approval of manuscript. Publisher Copyright: {\textcopyright} 2018, Copyright the Authors Journal compilation {\textcopyright} 2018, The American Geriatrics Society",
year = "2018",
month = dec,
doi = "10.1111/jgs.15613",
language = "English (US)",
volume = "66",
pages = "2314--2320",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "12",
}