TY - JOUR
T1 - Association between sleep disturbances with neurodevelopmental problems and decreased health-related quality of life in children with fontan circulation
AU - Knobbe, Kirstin
AU - Partha, Meghana
AU - Seckeler, Michael D.
AU - Klewer, Scott
AU - Hsu, Chiu Hsieh
AU - Edgin, Jamie
AU - Morgan, Wayne J.
AU - Provencio-Dean, Natalie
AU - Lopez, Silvia
AU - Parthasarathy, Sairam
AU - Combs, Daniel
N1 - Publisher Copyright: © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
PY - 2021/11/2
Y1 - 2021/11/2
N2 - BACKGROUND: Children with Fontan circulation are known to be at increased risk for neurodevelopmental problems and decreased health-related quality of life (HRQOL), but many factors that may contribute to this risk are unknown. Sleep disturbances may be one previously unidentified factor that contributes to this risk. METHODS AND RESULTS: We analyzed data from the Pediatric Heart Network Fontan cross-sectional study to evaluate associations between a parent or child report of sleep disturbance with reported neurodevelopmental concerns and HRQOL in 558 children with Fontan circulation. Parent-reported sleep disturbance was present in 11% of participants and child-reported sleep disturbance was present in 15%. Parent-reported sleep disturbance was associated with a significantly higher risk of attention problems, anxiety, depression, behavioral problems, and developmental delay (P<0.001 for all). Similarly, parent-reported disturbance was associated with decreased HRQOL on both parent and child-reported HRQOL (P<0.001 for most domains). Child-reported sleep disturbances were associated with increased odds of anxiety, depression, and attention problems as well as worse HRQOL. These associations were present even after adjustment for cardiac, demographic, and socioeconomic factors that may affect HRQOL and neurodevelopmental status. CONCLUSIONS: Sleep disturbances in children with Fontan circulation are associated with an increased risk of neurodevelop-mental problems as well as reduced HRQOL compared with those without sleep disturbance. Better understanding of sleep disturbances is needed in children with Fontan circulation, as sleep disturbances may represent a reversible cause of neu-rodevelopmental problems and decreased HRQOL in this population.
AB - BACKGROUND: Children with Fontan circulation are known to be at increased risk for neurodevelopmental problems and decreased health-related quality of life (HRQOL), but many factors that may contribute to this risk are unknown. Sleep disturbances may be one previously unidentified factor that contributes to this risk. METHODS AND RESULTS: We analyzed data from the Pediatric Heart Network Fontan cross-sectional study to evaluate associations between a parent or child report of sleep disturbance with reported neurodevelopmental concerns and HRQOL in 558 children with Fontan circulation. Parent-reported sleep disturbance was present in 11% of participants and child-reported sleep disturbance was present in 15%. Parent-reported sleep disturbance was associated with a significantly higher risk of attention problems, anxiety, depression, behavioral problems, and developmental delay (P<0.001 for all). Similarly, parent-reported disturbance was associated with decreased HRQOL on both parent and child-reported HRQOL (P<0.001 for most domains). Child-reported sleep disturbances were associated with increased odds of anxiety, depression, and attention problems as well as worse HRQOL. These associations were present even after adjustment for cardiac, demographic, and socioeconomic factors that may affect HRQOL and neurodevelopmental status. CONCLUSIONS: Sleep disturbances in children with Fontan circulation are associated with an increased risk of neurodevelop-mental problems as well as reduced HRQOL compared with those without sleep disturbance. Better understanding of sleep disturbances is needed in children with Fontan circulation, as sleep disturbances may represent a reversible cause of neu-rodevelopmental problems and decreased HRQOL in this population.
KW - Cognitive impairment
KW - Fontan procedure
KW - Quality of life
KW - Single ventricle
KW - Sleep
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U2 - 10.1161/JAHA.121.021749
DO - 10.1161/JAHA.121.021749
M3 - Article
C2 - 34668394
SN - 2047-9980
VL - 10
JO - Journal of the American Heart Association
JF - Journal of the American Heart Association
IS - 21
M1 - e021749
ER -