Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma

William G. Albergotti; Kara S. Davis; Shira Abberbock; Julie E. Bauman; James Ohr; David A. Clump; Dwight E. Heron; Umamaheswar Duvvuri; Seungwon Kim; Jonas T. Johnson; Robert L. Ferris

doi:10.1016/j.oraloncology.2016.07.003

Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma

William G. Albergotti, Kara S. Davis, Shira Abberbock, Julie E. Bauman, James Ohr, David A. Clump, Dwight E. Heron, Umamaheswar Duvvuri, Seungwon Kim, Jonas T. Johnson, Robert L. Ferris

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Background Pretreatment body mass index (BMI) >25 kg/m² is a positive prognostic factor in patients with head and neck cancer. Previous studies have not been adequately stratified by human papilloma virus (HPV) status or subsite. Our objective is to determine prognostic significance of pretreatment BMI on overall survival in HPV+ oropharyngeal squamous cell carcinoma (OPSCC). Methods This is a retrospective review of patients with HPV+ OPSCC treated between 8/1/2006 and 8/31/2014. Patients were stratified by BMI status (>/<25 kg/m²). Univariate and multivariate analyses of survival were performed. Results 300 patients met our inclusion/exclusion criteria. Patients with a BMI >25 kg/m² had a longer overall survival (HR = 0.49, P = 0.01) as well as a longer disease-specific survival (HR = 0.43, P = 0.02). Overall survival remained significantly associated with high BMI on multivariate analysis (HR = 0.54, P = 0.04). Conclusions Pre-treatment normal or underweight BMI status is associated with worse overall survival in HPV+ OPSCC.

Original language	English (US)
Pages (from-to)	55-60
Number of pages	6
Journal	Oral Oncology
Volume	60
DOIs	https://doi.org/10.1016/j.oraloncology.2016.07.003
State	Published - Sep 1 2016
Externally published	Yes

Keywords

Body mass index
Human papillomavirus
Oropharyngeal squamous cell carcinoma
Survival

ASJC Scopus subject areas

Oral Surgery
Oncology
Cancer Research

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10.1016/j.oraloncology.2016.07.003

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@article{4825ef3d2e3a4f848c325ec77529f94e,

title = "Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma",

abstract = "Background Pretreatment body mass index (BMI) >25 kg/m2 is a positive prognostic factor in patients with head and neck cancer. Previous studies have not been adequately stratified by human papilloma virus (HPV) status or subsite. Our objective is to determine prognostic significance of pretreatment BMI on overall survival in HPV+ oropharyngeal squamous cell carcinoma (OPSCC). Methods This is a retrospective review of patients with HPV+ OPSCC treated between 8/1/2006 and 8/31/2014. Patients were stratified by BMI status (>/<25 kg/m2). Univariate and multivariate analyses of survival were performed. Results 300 patients met our inclusion/exclusion criteria. Patients with a BMI >25 kg/m2 had a longer overall survival (HR = 0.49, P = 0.01) as well as a longer disease-specific survival (HR = 0.43, P = 0.02). Overall survival remained significantly associated with high BMI on multivariate analysis (HR = 0.54, P = 0.04). Conclusions Pre-treatment normal or underweight BMI status is associated with worse overall survival in HPV+ OPSCC.",

keywords = "Body mass index, Human papillomavirus, Oropharyngeal squamous cell carcinoma, Survival",

author = "Albergotti, {William G.} and Davis, {Kara S.} and Shira Abberbock and Bauman, {Julie E.} and James Ohr and Clump, {David A.} and Heron, {Dwight E.} and Umamaheswar Duvvuri and Seungwon Kim and Johnson, {Jonas T.} and Ferris, {Robert L.}",

note = "Funding Information: This works was supported in part by a Career Development Award from the Department of Veterans Affairs , BLR&D and a Grant from the PNC Foundation (U.D.). Funding Information: Contract grant sponsor: This project was conducted using the University of Pittsburgh Cancer Institute Biostatistics Facility that is supported in part by award P30CA047904 . Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2016",

month = sep,

day = "1",

doi = "10.1016/j.oraloncology.2016.07.003",

language = "English (US)",

volume = "60",

pages = "55--60",

journal = "Oral Oncology",

issn = "1368-8375",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma

AU - Albergotti, William G.

AU - Davis, Kara S.

AU - Abberbock, Shira

AU - Bauman, Julie E.

AU - Ohr, James

AU - Clump, David A.

AU - Heron, Dwight E.

AU - Duvvuri, Umamaheswar

AU - Kim, Seungwon

AU - Johnson, Jonas T.

AU - Ferris, Robert L.

N1 - Funding Information: This works was supported in part by a Career Development Award from the Department of Veterans Affairs , BLR&D and a Grant from the PNC Foundation (U.D.). Funding Information: Contract grant sponsor: This project was conducted using the University of Pittsburgh Cancer Institute Biostatistics Facility that is supported in part by award P30CA047904 . Publisher Copyright: © 2016 Elsevier Ltd

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Background Pretreatment body mass index (BMI) >25 kg/m2 is a positive prognostic factor in patients with head and neck cancer. Previous studies have not been adequately stratified by human papilloma virus (HPV) status or subsite. Our objective is to determine prognostic significance of pretreatment BMI on overall survival in HPV+ oropharyngeal squamous cell carcinoma (OPSCC). Methods This is a retrospective review of patients with HPV+ OPSCC treated between 8/1/2006 and 8/31/2014. Patients were stratified by BMI status (>/<25 kg/m2). Univariate and multivariate analyses of survival were performed. Results 300 patients met our inclusion/exclusion criteria. Patients with a BMI >25 kg/m2 had a longer overall survival (HR = 0.49, P = 0.01) as well as a longer disease-specific survival (HR = 0.43, P = 0.02). Overall survival remained significantly associated with high BMI on multivariate analysis (HR = 0.54, P = 0.04). Conclusions Pre-treatment normal or underweight BMI status is associated with worse overall survival in HPV+ OPSCC.

AB - Background Pretreatment body mass index (BMI) >25 kg/m2 is a positive prognostic factor in patients with head and neck cancer. Previous studies have not been adequately stratified by human papilloma virus (HPV) status or subsite. Our objective is to determine prognostic significance of pretreatment BMI on overall survival in HPV+ oropharyngeal squamous cell carcinoma (OPSCC). Methods This is a retrospective review of patients with HPV+ OPSCC treated between 8/1/2006 and 8/31/2014. Patients were stratified by BMI status (>/<25 kg/m2). Univariate and multivariate analyses of survival were performed. Results 300 patients met our inclusion/exclusion criteria. Patients with a BMI >25 kg/m2 had a longer overall survival (HR = 0.49, P = 0.01) as well as a longer disease-specific survival (HR = 0.43, P = 0.02). Overall survival remained significantly associated with high BMI on multivariate analysis (HR = 0.54, P = 0.04). Conclusions Pre-treatment normal or underweight BMI status is associated with worse overall survival in HPV+ OPSCC.

KW - Body mass index

KW - Human papillomavirus

KW - Oropharyngeal squamous cell carcinoma

KW - Survival

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DO - 10.1016/j.oraloncology.2016.07.003

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C2 - 27531873

SN - 1368-8375

VL - 60

SP - 55

EP - 60

JO - Oral Oncology

JF - Oral Oncology

ER -

Association of pretreatment body mass index and survival in human papillomavirus positive oropharyngeal squamous cell carcinoma

Abstract

Keywords

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