Associations Among Sex, Cognitive Ability, and Autism Symptoms in Individuals with Down Syndrome

Laura del Hoyo Soriano; Audra Sterling; Jamie Edgin; Debra R. Hamilton; Elizabeth Berry-Kravis; Amanda Dimachkie Nunnally; Angela John Thurman; Leonard Abbeduto

doi:10.1007/s10803-022-05779-6

Associations Among Sex, Cognitive Ability, and Autism Symptoms in Individuals with Down Syndrome

Laura del Hoyo Soriano, Audra Sterling, Jamie Edgin, Debra R. Hamilton, Elizabeth Berry-Kravis, Amanda Dimachkie Nunnally, Angela John Thurman, Leonard Abbeduto

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This study explores sex-differences in (a) rates and profiles of autism symptoms as well as in (b) the contribution of intellectual quotient (IQ) to autism symptom presentation in Down syndrome (DS). Participants were 40 males and 38 females with DS, aged 6 to 23 years. Autism symptoms were rated through the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2). Results show no sex differences in the ADOS-2 Calibrated Severity Scores (CSS). However, only females with DS who are classified as DS-Only have higher scores on verbal IQ than those classified as DS + autism. Furthermore, associations between IQ and all CSSs are found for females, but not for males. Findings suggest that verbal cognition may play differential roles for females and males with DS.

Original language	English (US)
Pages (from-to)	301-311
Number of pages	11
Journal	Journal of Autism and Developmental Disorders
Volume	54
Issue number	1
DOIs	https://doi.org/10.1007/s10803-022-05779-6
State	Published - Jan 2024

Keywords

Autism
Cognitive ability
Down syndrome
Females
Sex-differences

ASJC Scopus subject areas

Developmental and Educational Psychology

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10.1007/s10803-022-05779-6

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title = "Associations Among Sex, Cognitive Ability, and Autism Symptoms in Individuals with Down Syndrome",

abstract = "This study explores sex-differences in (a) rates and profiles of autism symptoms as well as in (b) the contribution of intellectual quotient (IQ) to autism symptom presentation in Down syndrome (DS). Participants were 40 males and 38 females with DS, aged 6 to 23 years. Autism symptoms were rated through the Autism Diagnostic Observation Schedule-Second Edition (ADOS-2). Results show no sex differences in the ADOS-2 Calibrated Severity Scores (CSS). However, only females with DS who are classified as DS-Only have higher scores on verbal IQ than those classified as DS + autism. Furthermore, associations between IQ and all CSSs are found for females, but not for males. Findings suggest that verbal cognition may play differential roles for females and males with DS.",

keywords = "Autism, Cognitive ability, Down syndrome, Females, Sex-differences",

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doi = "10.1007/s10803-022-05779-6",

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AU - Berry-Kravis, Elizabeth

AU - Dimachkie Nunnally, Amanda

AU - Thurman, Angela John

AU - Abbeduto, Leonard

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Associations Among Sex, Cognitive Ability, and Autism Symptoms in Individuals with Down Syndrome

Abstract

Keywords

ASJC Scopus subject areas

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