Biochemical genesis of enzymatic and non-enzymatic post-translational modifications

Erin Q. Jennings; Kristofer S. Fritz; James J. Galligan

doi:10.1016/j.mam.2021.101053

Biochemical genesis of enzymatic and non-enzymatic post-translational modifications

Erin Q. Jennings, Kristofer S. Fritz, James J. Galligan

Pharmacology and Toxicology

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Post-translational modifications (PTMs) alter protein structure, function, and localization and play a pivotal role in physiological and pathophysiological conditions. Many PTMs arise from endogenous metabolic intermediates and serve as sensors for metabolic feedback to maintain cell growth and homeostasis. A key feature to PTMs is their biochemical genesis, which can result from either non-enzymatic adduction (nPTMs) or through enzyme-catalyzed reactions (ePTMs). The abundance and site-specificity of PTMs are determined by dedicated classes of enzymes that add (writers) or remove (erasers) the chemical addition. In this review we will highlight the biochemical genesis and regulation of a few of the 700+ PTMs that have been identified.

Original language	English (US)
Article number	101053
Journal	Molecular Aspects of Medicine
Volume	86
DOIs	https://doi.org/10.1016/j.mam.2021.101053
State	Published - Aug 2022

Keywords

Acylation
Glycation
Glycosylation
Glyoxalase
Metabolism
Sirtuin
Sulfenylation

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry

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10.1016/j.mam.2021.101053

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title = "Biochemical genesis of enzymatic and non-enzymatic post-translational modifications",

abstract = "Post-translational modifications (PTMs) alter protein structure, function, and localization and play a pivotal role in physiological and pathophysiological conditions. Many PTMs arise from endogenous metabolic intermediates and serve as sensors for metabolic feedback to maintain cell growth and homeostasis. A key feature to PTMs is their biochemical genesis, which can result from either non-enzymatic adduction (nPTMs) or through enzyme-catalyzed reactions (ePTMs). The abundance and site-specificity of PTMs are determined by dedicated classes of enzymes that add (writers) or remove (erasers) the chemical addition. In this review we will highlight the biochemical genesis and regulation of a few of the 700+ PTMs that have been identified.",

keywords = "Acylation, Glycation, Glycosylation, Glyoxalase, Metabolism, Sirtuin, Sulfenylation",

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language = "English (US)",

volume = "86",

journal = "Molecular Aspects of Medicine",

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T1 - Biochemical genesis of enzymatic and non-enzymatic post-translational modifications

AU - Jennings, Erin Q.

AU - Fritz, Kristofer S.

AU - Galligan, James J.

PY - 2022/8

Y1 - 2022/8

N2 - Post-translational modifications (PTMs) alter protein structure, function, and localization and play a pivotal role in physiological and pathophysiological conditions. Many PTMs arise from endogenous metabolic intermediates and serve as sensors for metabolic feedback to maintain cell growth and homeostasis. A key feature to PTMs is their biochemical genesis, which can result from either non-enzymatic adduction (nPTMs) or through enzyme-catalyzed reactions (ePTMs). The abundance and site-specificity of PTMs are determined by dedicated classes of enzymes that add (writers) or remove (erasers) the chemical addition. In this review we will highlight the biochemical genesis and regulation of a few of the 700+ PTMs that have been identified.

AB - Post-translational modifications (PTMs) alter protein structure, function, and localization and play a pivotal role in physiological and pathophysiological conditions. Many PTMs arise from endogenous metabolic intermediates and serve as sensors for metabolic feedback to maintain cell growth and homeostasis. A key feature to PTMs is their biochemical genesis, which can result from either non-enzymatic adduction (nPTMs) or through enzyme-catalyzed reactions (ePTMs). The abundance and site-specificity of PTMs are determined by dedicated classes of enzymes that add (writers) or remove (erasers) the chemical addition. In this review we will highlight the biochemical genesis and regulation of a few of the 700+ PTMs that have been identified.

KW - Acylation

KW - Glycation

KW - Glycosylation

KW - Glyoxalase

KW - Metabolism

KW - Sirtuin

KW - Sulfenylation

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DO - 10.1016/j.mam.2021.101053

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VL - 86

JO - Molecular Aspects of Medicine

JF - Molecular Aspects of Medicine

M1 - 101053

ER -

Biochemical genesis of enzymatic and non-enzymatic post-translational modifications

Abstract

Keywords

ASJC Scopus subject areas

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