Abstract
A study has illustrated the preparation and testing of biodegradable plasmon resonant nanoshells of 63 nm diameter formed using shell sprayed array of gold clusters supported on a spherical biodegradable core. The proposed grade of materials maintains optical tunability characteristics of solid metallic shells, and upon degradation yields individual clusters of 5.7 nm diameter, compatible with requirements of renal clearance. The attempt on biodegradable metallic nanoparticles may enable clinical translation of many research stage technologies. The study has prepared degradable plasmon resonant nanostructures, in which liposomes made of dialkyl phosphatidylcholine served as the spherical template, and also developed the composite shell obtained by formation of gold-lipid complexes. Biodegradable plasmon resonant contrast agents may improve clinical OCT images, and can also further enhance in vivo targeting and detection of molecular markers of diagnostic importance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2604-2608 |
| Number of pages | 5 |
| Journal | Advanced Materials |
| Volume | 20 |
| Issue number | 13 |
| DOIs | |
| State | Published - Jul 2 2008 |
ASJC Scopus subject areas
- General Materials Science
- Mechanics of Materials
- Mechanical Engineering