Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed

Katrina Lichauco; Mark S. Lee; Michael S. Kuhns

doi:https://doi.org/10.1016/j.immuni.2018.11.008

Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed

Katrina Lichauco, Mark S. Lee, Michael S. Kuhns

Research output: Contribution to journal › Short survey › peer-review

Abstract

How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active states. How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active states.

Original language	English (US)
Pages (from-to)	786-788
Number of pages	3
Journal	Immunity
Volume	49
Issue number	5
DOIs	https://doi.org/10.1016/j.immuni.2018.11.008
State	Published - Nov 20 2018

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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https://doi.org/10.1016/j.immuni.2018.11.008

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title = "Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed",

abstract = "How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active states. How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active states.",

author = "Katrina Lichauco and Lee, {Mark S.} and Kuhns, {Michael S.}",

note = "Funding Information: We thank Deepta Bhattahcharya, Dominik Schenten, and Nedal Taha for critical feedback. This work was supported by NIH/NIAID R01AI101053 (M.S.K.). Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

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AU - Lichauco, Katrina

AU - Lee, Mark S.

AU - Kuhns, Michael S.

N1 - Funding Information: We thank Deepta Bhattahcharya, Dominik Schenten, and Nedal Taha for critical feedback. This work was supported by NIH/NIAID R01AI101053 (M.S.K.). Publisher Copyright: © 2018 Elsevier Inc.

PY - 2018/11/20

Y1 - 2018/11/20

N2 - How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active states. How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active states.

AB - How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active states. How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active states.

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JO - Immunity

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Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed

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