Cardiac myosin-binding protein C interaction with actin is inhibited by compounds identified in a high-throughput fluorescence lifetime screen

Keyphrases

• High-throughput 100%
• Actin 100%
• Fluorescence Lifetime 100%
• Myosin-binding Protein C 100%
• Phosphorylation 33%
• Phosphorescence 16%
• High-throughput Screening 16%
• Anisotropy 16%
• Heart Failure 16%
• Alexa Fluor 488 16%
• Cardiac Contractility 16%
• Actin Binding 16%
• Binding Site 8%
• Myosin 8%
• Small Molecule Inhibitors 8%
• Fluorescent Dye 8%
• Binding Assay 8%
• Isothermal Titration Calorimetry 8%
• Cardioprotection 8%
• Known-key 8%
• Heart Failure Patients 8%
• Compound Library 8%
• Actin-myosin 8%
• Aurintricarboxylic Acid 8%
• N-terminal Fragment 8%
• Time-resolved FRET 8%
• Hit Compound 8%
• Suramin 8%
• Heart Failure Medication 8%
• Pharmacologically Active Compounds 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Actin 100%
• Myosin Binding Protein C 100%
• Cardiac Myosin 100%
• Heart Failure 30%
• Calorimetry 7%
• Fluorescent Dye 7%
• Binding Site 7%
• Aurintricarboxylic Acid 7%
• Suramin 7%

Biochemistry, Genetics and Molecular Biology

• Suramin 7%