Cell-free dna as an addition to ultrasound for screening of a complete hydatidiform mole and coexisting normal fetus pregnancy: A case report

Martina G. Gabra; Maritza G. Gonzalez; Holly N. Bullock; Meghan G. Hill

doi:10.1055/s-0040-1709981

Cell-free dna as an addition to ultrasound for screening of a complete hydatidiform mole and coexisting normal fetus pregnancy: A case report

Martina G. Gabra, Maritza G. Gonzalez, Holly N. Bullock, Meghan G. Hill

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background Complete hydatidiform mole and coexisting normal fetus pregnancies (CHMCF) are rare and can be life-threatening to the mother. Definitive diagnosis can be made with chorionic villus sampling or amniocentesis. However invasive procedures carry a risk of bleeding. We present the case of a twin molar pregnancy where a cell-free DNA screening test was utilized to evaluate for CHMCF pregnancy. Case A patient presented at 15-week gestational age with suspected CHMCF pregnancy. Ultrasound revealed a normal-appearing pregnancy abutting a multicystic lesion concerning for a complete mole. Cell-free DNA was obtained and was suggestive of complete paternal uniparental disomy. Pathological evaluation of the products of conception confirmed the diagnosis of CHMCF.

Original language	English (US)
Pages (from-to)	E176-E178
Journal	AJP Reports
Volume	10
Issue number	2
DOIs	https://doi.org/10.1055/s-0040-1709981
State	Published - Apr 1 2020

Keywords

Cell-free dna
Complete hydatidiform mole and coexisting normal fetus
Hyperemesis gravidarum
Twin-molar pregnancy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1055/s-0040-1709981

Cite this

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title = "Cell-free dna as an addition to ultrasound for screening of a complete hydatidiform mole and coexisting normal fetus pregnancy: A case report",

abstract = "Background Complete hydatidiform mole and coexisting normal fetus pregnancies (CHMCF) are rare and can be life-threatening to the mother. Definitive diagnosis can be made with chorionic villus sampling or amniocentesis. However invasive procedures carry a risk of bleeding. We present the case of a twin molar pregnancy where a cell-free DNA screening test was utilized to evaluate for CHMCF pregnancy. Case A patient presented at 15-week gestational age with suspected CHMCF pregnancy. Ultrasound revealed a normal-appearing pregnancy abutting a multicystic lesion concerning for a complete mole. Cell-free DNA was obtained and was suggestive of complete paternal uniparental disomy. Pathological evaluation of the products of conception confirmed the diagnosis of CHMCF.",

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AU - Bullock, Holly N.

AU - Hill, Meghan G.

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Background Complete hydatidiform mole and coexisting normal fetus pregnancies (CHMCF) are rare and can be life-threatening to the mother. Definitive diagnosis can be made with chorionic villus sampling or amniocentesis. However invasive procedures carry a risk of bleeding. We present the case of a twin molar pregnancy where a cell-free DNA screening test was utilized to evaluate for CHMCF pregnancy. Case A patient presented at 15-week gestational age with suspected CHMCF pregnancy. Ultrasound revealed a normal-appearing pregnancy abutting a multicystic lesion concerning for a complete mole. Cell-free DNA was obtained and was suggestive of complete paternal uniparental disomy. Pathological evaluation of the products of conception confirmed the diagnosis of CHMCF.

AB - Background Complete hydatidiform mole and coexisting normal fetus pregnancies (CHMCF) are rare and can be life-threatening to the mother. Definitive diagnosis can be made with chorionic villus sampling or amniocentesis. However invasive procedures carry a risk of bleeding. We present the case of a twin molar pregnancy where a cell-free DNA screening test was utilized to evaluate for CHMCF pregnancy. Case A patient presented at 15-week gestational age with suspected CHMCF pregnancy. Ultrasound revealed a normal-appearing pregnancy abutting a multicystic lesion concerning for a complete mole. Cell-free DNA was obtained and was suggestive of complete paternal uniparental disomy. Pathological evaluation of the products of conception confirmed the diagnosis of CHMCF.

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Cell-free dna as an addition to ultrasound for screening of a complete hydatidiform mole and coexisting normal fetus pregnancy: A case report

Abstract

Keywords

ASJC Scopus subject areas

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