Cell mediated hypersensitivity in guinea pigs infected with Toxoplasma gondii

D. D. Ourth; M. N. Lunde; R. R. Watson

doi:10.1016/s0300-872x(76)80041-8

Cell mediated hypersensitivity in guinea pigs infected with Toxoplasma gondii

D. D. Ourth
, M. N. Lunde
, R. R. Watson

Health Promotion Sciences

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

This investigation demonstrated delayed hypersensitivity by macrophage migration inhibition (MMI) and skin testing (ST) at 4, 8, 12, and 17 weeks and by lymphocyte transformation (LT) at 4, 12, and 17 weeks after infection of guinea pigs (GP) with Toxoplasma gondii (C 37 strain). MMI and LT were both most pronounced at 4 and 17 weeks post infection. GP immunized with toxoplasmin in complete Freund's adjuvant (CFA) demonstrated positive blast transformation and ST, but GP immunized with phosphate buffered saline in CFA did not. MMI was demonstrated with both immunizing preparations. Positive dye test and indirect hemagglutination test titers from 4 through 17 weeks were found.

Original language	English (US)
Pages (from-to)	254-262
Number of pages	9
Journal	Zeitschrift fur Immunitatsforschung
Volume	151
Issue number	3
DOIs	https://doi.org/10.1016/s0300-872x(76)80041-8
State	Published - 1976

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/s0300-872x(76)80041-8

Cite this

@article{f8ee7a74a6c849f5a7d3b6c5429db6bf,

title = "Cell mediated hypersensitivity in guinea pigs infected with Toxoplasma gondii",

abstract = "This investigation demonstrated delayed hypersensitivity by macrophage migration inhibition (MMI) and skin testing (ST) at 4, 8, 12, and 17 weeks and by lymphocyte transformation (LT) at 4, 12, and 17 weeks after infection of guinea pigs (GP) with Toxoplasma gondii (C 37 strain). MMI and LT were both most pronounced at 4 and 17 weeks post infection. GP immunized with toxoplasmin in complete Freund's adjuvant (CFA) demonstrated positive blast transformation and ST, but GP immunized with phosphate buffered saline in CFA did not. MMI was demonstrated with both immunizing preparations. Positive dye test and indirect hemagglutination test titers from 4 through 17 weeks were found.",

author = "Ourth, \{D. D.\} and Lunde, \{M. N.\} and Watson, \{R. R.\}",

year = "1976",

doi = "10.1016/s0300-872x(76)80041-8",

language = "English (US)",

volume = "151",

pages = "254--262",

journal = "Zeitschrift fur Immunitatsforschung",

issn = "0340-904X",

publisher = "Urban und Fischer Verlag GmbH und Co. KG",

number = "3",

}

TY - JOUR

T1 - Cell mediated hypersensitivity in guinea pigs infected with Toxoplasma gondii

AU - Ourth, D. D.

AU - Lunde, M. N.

AU - Watson, R. R.

PY - 1976

Y1 - 1976

N2 - This investigation demonstrated delayed hypersensitivity by macrophage migration inhibition (MMI) and skin testing (ST) at 4, 8, 12, and 17 weeks and by lymphocyte transformation (LT) at 4, 12, and 17 weeks after infection of guinea pigs (GP) with Toxoplasma gondii (C 37 strain). MMI and LT were both most pronounced at 4 and 17 weeks post infection. GP immunized with toxoplasmin in complete Freund's adjuvant (CFA) demonstrated positive blast transformation and ST, but GP immunized with phosphate buffered saline in CFA did not. MMI was demonstrated with both immunizing preparations. Positive dye test and indirect hemagglutination test titers from 4 through 17 weeks were found.

AB - This investigation demonstrated delayed hypersensitivity by macrophage migration inhibition (MMI) and skin testing (ST) at 4, 8, 12, and 17 weeks and by lymphocyte transformation (LT) at 4, 12, and 17 weeks after infection of guinea pigs (GP) with Toxoplasma gondii (C 37 strain). MMI and LT were both most pronounced at 4 and 17 weeks post infection. GP immunized with toxoplasmin in complete Freund's adjuvant (CFA) demonstrated positive blast transformation and ST, but GP immunized with phosphate buffered saline in CFA did not. MMI was demonstrated with both immunizing preparations. Positive dye test and indirect hemagglutination test titers from 4 through 17 weeks were found.

UR - https://www.scopus.com/pages/publications/0017227650

UR - https://www.scopus.com/pages/publications/0017227650#tab=citedBy

U2 - 10.1016/s0300-872x(76)80041-8

DO - 10.1016/s0300-872x(76)80041-8

M3 - Article

C2 - 134544

SN - 0340-904X

VL - 151

SP - 254

EP - 262

JO - Zeitschrift fur Immunitatsforschung

JF - Zeitschrift fur Immunitatsforschung

IS - 3

ER -

Cell mediated hypersensitivity in guinea pigs infected with Toxoplasma gondii

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this