TY - JOUR
T1 - Characterization of neonatal opioid withdrawal syndrome in Arizona from 2010-2017
AU - Eaves, Emery R.
AU - Barber, Jarrett
AU - Whealy, Ryann
AU - Clancey, Sara A.
AU - Wright, Rita
AU - Cocking, Jill Hager
AU - Spadafino, Joseph
AU - Hepp, Crystal M.
N1 - Funding Information: This work was supported by a Pilot grant project to Crystal Hepp, Ph.D. as part of the NIH/ NIMHD RCMI U54MD012388 (Julie Baldwin, Ph.D. PI). The authors acknowledge the contributions of Arizona Department of Health Services staff members Kyle Gardner and Timothy Flood for assistance defining the data request, the Northern Arizona University Information Technology Services for managing data security issues, and the Southwest Health Equity Research Collaborative Research Infrastructure Core for analytical assistance. Publisher Copyright: Copyright: © 2021 Eaves et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2021/6
Y1 - 2021/6
N2 - In this paper, we describe a population of mothers who are opioid dependent at the time of giving birth and neonates exposed to opioids in utero who experience withdrawal following birth. While there have been studies of national trends in this population, there remains a gap in studies of regional trends. Using data from the Arizona Department of Health Services Hospital Discharge Database, this study aimed to characterize the population of neonates with neonatal opioid withdrawal syndrome (NOWS) and mothers who were opioid dependent at the time of giving birth, in Arizona. We analyzed approximately 1.2 million electronic medical records from the Arizona Department of Health Services Hospital Discharge Database to identify patterns and disparities across socioeconomic, ethnic, racial, and/or geographic groupings. In addition, we identified comorbid conditions that are differentially associated with NOWS in neonates or opioid dependence in mothers. Our analysis was designed to assess whether indicators such as race/ethnicity, insurance payer, marital status, and comorbidities are related to the use of opioids while pregnant. Our findings suggest that women and neonates who are non-Hispanic White and economically disadvantaged, tend be part of our populations of interest more frequently than expected. Additionally, women who are opioid dependent at the time of giving birth are unmarried more often than expected, and we suggest that marital status could be a proxy for support. Finally, we identified comorbidities associated with neonates who have NOWS and mothers who are opioid dependent not previously reported.
AB - In this paper, we describe a population of mothers who are opioid dependent at the time of giving birth and neonates exposed to opioids in utero who experience withdrawal following birth. While there have been studies of national trends in this population, there remains a gap in studies of regional trends. Using data from the Arizona Department of Health Services Hospital Discharge Database, this study aimed to characterize the population of neonates with neonatal opioid withdrawal syndrome (NOWS) and mothers who were opioid dependent at the time of giving birth, in Arizona. We analyzed approximately 1.2 million electronic medical records from the Arizona Department of Health Services Hospital Discharge Database to identify patterns and disparities across socioeconomic, ethnic, racial, and/or geographic groupings. In addition, we identified comorbid conditions that are differentially associated with NOWS in neonates or opioid dependence in mothers. Our analysis was designed to assess whether indicators such as race/ethnicity, insurance payer, marital status, and comorbidities are related to the use of opioids while pregnant. Our findings suggest that women and neonates who are non-Hispanic White and economically disadvantaged, tend be part of our populations of interest more frequently than expected. Additionally, women who are opioid dependent at the time of giving birth are unmarried more often than expected, and we suggest that marital status could be a proxy for support. Finally, we identified comorbidities associated with neonates who have NOWS and mothers who are opioid dependent not previously reported.
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U2 - https://doi.org/10.1371/journal.pone.0248476
DO - https://doi.org/10.1371/journal.pone.0248476
M3 - Review article
C2 - 34081702
SN - 1932-6203
VL - 16
JO - PLoS One
JF - PLoS One
IS - 6 June
M1 - e0248476
ER -