CHK it out! Blocking WEE kinase routs TP53 mutant cancer

Julie E. Bauman; Christine H. Chung

doi:10.1158/1078-0432.CCR-14-0720

CHK it out! Blocking WEE kinase routs TP53 mutant cancer

Julie E. Bauman
, Christine H. Chung

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Mutations in TP53, encoding the master tumor suppressor p53, have posed a developmental therapeutic dilemma due to inability to target loss of function. Inhibition of WEE1 or CHK1 kinase, negative regulators of the G₂-M checkpoint, selectively sensitizes p53-deficient cells to exogenous DNA damage, abrogating G₂ arrest and precipitating mitotic catastrophe.

Original language	English (US)
Pages (from-to)	4173-4175
Number of pages	3
Journal	Clinical Cancer Research
Volume	20
Issue number	16
DOIs	https://doi.org/10.1158/1078-0432.CCR-14-0720
State	Published - Aug 15 2014
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1158/1078-0432.CCR-14-0720

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title = "CHK it out! Blocking WEE kinase routs TP53 mutant cancer",

abstract = "Mutations in TP53, encoding the master tumor suppressor p53, have posed a developmental therapeutic dilemma due to inability to target loss of function. Inhibition of WEE1 or CHK1 kinase, negative regulators of the G2-M checkpoint, selectively sensitizes p53-deficient cells to exogenous DNA damage, abrogating G2 arrest and precipitating mitotic catastrophe.",

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AU - Chung, Christine H.

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N2 - Mutations in TP53, encoding the master tumor suppressor p53, have posed a developmental therapeutic dilemma due to inability to target loss of function. Inhibition of WEE1 or CHK1 kinase, negative regulators of the G2-M checkpoint, selectively sensitizes p53-deficient cells to exogenous DNA damage, abrogating G2 arrest and precipitating mitotic catastrophe.

AB - Mutations in TP53, encoding the master tumor suppressor p53, have posed a developmental therapeutic dilemma due to inability to target loss of function. Inhibition of WEE1 or CHK1 kinase, negative regulators of the G2-M checkpoint, selectively sensitizes p53-deficient cells to exogenous DNA damage, abrogating G2 arrest and precipitating mitotic catastrophe.

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UR - https://www.scopus.com/pages/publications/84905973961#tab=citedBy

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DO - 10.1158/1078-0432.CCR-14-0720

M3 - Article

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SN - 1078-0432

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SP - 4173

EP - 4175

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 16

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CHK it out! Blocking WEE kinase routs TP53 mutant cancer

Abstract

ASJC Scopus subject areas

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