Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus

Eunice Molinar; Nivia Rios; Carmenza Spadafora; A. Elizabeth Arnold; Phyllis D. Coley; Thomas A. Kursar; William H. Gerwick; Luis Cubilla-Rios

doi:10.1016/j.tetlet.2011.12.021

Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus

Eunice Molinar, Nivia Rios, Carmenza Spadafora, A. Elizabeth Arnold, Phyllis D. Coley, Thomas A. Kursar, William H. Gerwick, Luis Cubilla-Rios

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Three new terpenoids of mixed biosynthetic origin were isolated from the culture filtrate of the endophytic fungus Pycnoporus sanguineus. Their structures were determined by extensive spectroscopic analyses. We have named these tricyclic and tetracyclic metabolites 'coibanoles A-C' in reference to Coiba Island and Coiba National Park, Panamá, from which the plant and endophyte were collected. The extract was inactive to the human parasites Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum at a test concentration of 10 μg/mL.

Original language	English (US)
Pages (from-to)	919-922
Number of pages	4
Journal	Tetrahedron Letters
Volume	53
Issue number	8
DOIs	https://doi.org/10.1016/j.tetlet.2011.12.021
State	Published - Feb 22 2012

Keywords

Coibanoles
Leishmania
Meroterpenoids
Pycnoporus
Trypanosoma

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2011.12.021

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title = "Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus",

abstract = "Three new terpenoids of mixed biosynthetic origin were isolated from the culture filtrate of the endophytic fungus Pycnoporus sanguineus. Their structures were determined by extensive spectroscopic analyses. We have named these tricyclic and tetracyclic metabolites 'coibanoles A-C' in reference to Coiba Island and Coiba National Park, Panam{\'a}, from which the plant and endophyte were collected. The extract was inactive to the human parasites Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum at a test concentration of 10 μg/mL.",

keywords = "Coibanoles, Leishmania, Meroterpenoids, Pycnoporus, Trypanosoma",

author = "Eunice Molinar and Nivia Rios and Carmenza Spadafora and {Elizabeth Arnold}, A. and Coley, {Phyllis D.} and Kursar, {Thomas A.} and Gerwick, {William H.} and Luis Cubilla-Rios",

note = "Funding Information: This work was supported by US NIH Grant for the International Cooperative Biodiversity Groups program (ICBG–Panama; 2 U01 TW006634-06). We thank M. Gunatilaka and D. Mahana for assistance with DNA sequencing, and the College of Agriculture and Life Sciences at the University of Arizona for logistical and financial support. We also give our thanks to the personnel of Panam{\'a}′s Autoridad Nacional del Ambiente for their assistance in conducting this research project.",

year = "2012",

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doi = "10.1016/j.tetlet.2011.12.021",

language = "English (US)",

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AU - Molinar, Eunice

AU - Rios, Nivia

AU - Spadafora, Carmenza

AU - Elizabeth Arnold, A.

AU - Coley, Phyllis D.

AU - Kursar, Thomas A.

AU - Gerwick, William H.

AU - Cubilla-Rios, Luis

N1 - Funding Information: This work was supported by US NIH Grant for the International Cooperative Biodiversity Groups program (ICBG–Panama; 2 U01 TW006634-06). We thank M. Gunatilaka and D. Mahana for assistance with DNA sequencing, and the College of Agriculture and Life Sciences at the University of Arizona for logistical and financial support. We also give our thanks to the personnel of Panamá′s Autoridad Nacional del Ambiente for their assistance in conducting this research project.

PY - 2012/2/22

Y1 - 2012/2/22

N2 - Three new terpenoids of mixed biosynthetic origin were isolated from the culture filtrate of the endophytic fungus Pycnoporus sanguineus. Their structures were determined by extensive spectroscopic analyses. We have named these tricyclic and tetracyclic metabolites 'coibanoles A-C' in reference to Coiba Island and Coiba National Park, Panamá, from which the plant and endophyte were collected. The extract was inactive to the human parasites Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum at a test concentration of 10 μg/mL.

AB - Three new terpenoids of mixed biosynthetic origin were isolated from the culture filtrate of the endophytic fungus Pycnoporus sanguineus. Their structures were determined by extensive spectroscopic analyses. We have named these tricyclic and tetracyclic metabolites 'coibanoles A-C' in reference to Coiba Island and Coiba National Park, Panamá, from which the plant and endophyte were collected. The extract was inactive to the human parasites Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum at a test concentration of 10 μg/mL.

KW - Coibanoles

KW - Leishmania

KW - Meroterpenoids

KW - Pycnoporus

KW - Trypanosoma

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DO - 10.1016/j.tetlet.2011.12.021

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 8

ER -

Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus

Abstract

Keywords

ASJC Scopus subject areas

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