Computer-aided classification of breast masses using contrast-enhanced digital mammograms

Gopichandh Danala, Faranak Aghaei, Morteza Heidari, Teresa Wu, Bhavika Patel, Bin Zheng

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations


By taking advantages of both mammography and breast MRI, contrast-enhanced digital mammography (CEDM) has emerged as a new promising imaging modality to improve efficacy of breast cancer screening and diagnosis. The primary objective of study is to develop and evaluate a new computer-aided detection and diagnosis (CAD) scheme of CEDM images to classify between malignant and benign breast masses. A CEDM dataset consisting of 111 patients (33 benign and 78 malignant) was retrospectively assembled. Each case includes two types of images namely, low-energy (LE) and dual-energy subtracted (DES) images. First, CAD scheme applied a hybrid segmentation method to automatically segment masses depicting on LE and DES images separately. Optimal segmentation results from DES images were also mapped to LE images and vice versa. Next, a set of 109 quantitative image features related to mass shape and density heterogeneity was initially computed. Last, four multilayer perceptron-based machine learning classifiers integrated with correlationbased feature subset evaluator and leave-one-case-out cross-validation method was built to classify mass regions depicting on LE and DES images, respectively. Initially, when CAD scheme was applied to original segmentation of DES and LE images, the areas under ROC curves were 0.7585±0.0526 and 0.7534±0.0470, respectively. After optimal segmentation mapping from DES to LE images, AUC value of CAD scheme significantly increased to 0.8477±0.0376 (p<0.01). Since DES images eliminate overlapping effect of dense breast tissue on lesions, segmentation accuracy was significantly improved as compared to regular mammograms, the study demonstrated that computer-aided classification of breast masses using CEDM images yielded higher performance.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2018
Subtitle of host publicationComputer-Aided Diagnosis
EditorsKensaku Mori, Nicholas Petrick
ISBN (Electronic)9781510616394
StatePublished - 2018
EventMedical Imaging 2018: Computer-Aided Diagnosis - Houston, United States
Duration: Feb 12 2018Feb 15 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE


OtherMedical Imaging 2018: Computer-Aided Diagnosis
Country/TerritoryUnited States


  • Contrast-enhanced digital mammography (CEDM)
  • Dual-energy subtracted (DES) image
  • Low energy (LE) image
  • Mammography
  • breast mass classification
  • computer-aided diagnosis (CAD)
  • correlationbased feature subset evaluator
  • multilayer perceptron

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials


Dive into the research topics of 'Computer-aided classification of breast masses using contrast-enhanced digital mammograms'. Together they form a unique fingerprint.

Cite this