Covalent binding of halogenated volatile solvents to subcellular macromolecules in hepatocytes

Michael L. Cunningham; A. Jay Gandolfi; Klaus Brendel; I. Glenn Sipes

doi:10.1016/0024-3205(81)90224-1

Covalent binding of halogenated volatile solvents to subcellular macromolecules in hepatocytes

Michael L. Cunningham, A. Jay Gandolfi, Klaus Brendel, I. Glenn Sipes

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Rat liver hepatocytes were used to bioactivate the aliphatic halides-carbon tetrachloride, trichloroethylene, and methylene chloride. Optimum bioactivation occured under a nitrogen atmosphere for carbon tetrachloride and under an oxygen atmosphere for trichloroethylene and methylene chloride. All were found to alkylate lipid and protein, while only carbon tetrachloride and trichloroethylene alkylated DNA and RNA.

Original language	English (US)
Pages (from-to)	1207-1212
Number of pages	6
Journal	Life Sciences
Volume	29
Issue number	12
DOIs	https://doi.org/10.1016/0024-3205(81)90224-1
State	Published - Sep 21 1981

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(81)90224-1

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title = "Covalent binding of halogenated volatile solvents to subcellular macromolecules in hepatocytes",

abstract = "Rat liver hepatocytes were used to bioactivate the aliphatic halides-carbon tetrachloride, trichloroethylene, and methylene chloride. Optimum bioactivation occured under a nitrogen atmosphere for carbon tetrachloride and under an oxygen atmosphere for trichloroethylene and methylene chloride. All were found to alkylate lipid and protein, while only carbon tetrachloride and trichloroethylene alkylated DNA and RNA.",

author = "Cunningham, {Michael L.} and {Jay Gandolfi}, A. and Klaus Brendel and {Glenn Sipes}, I.",

note = "Funding Information: This research was supported by NIH Grant CA 21820.",

year = "1981",

month = sep,

day = "21",

doi = "10.1016/0024-3205(81)90224-1",

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T1 - Covalent binding of halogenated volatile solvents to subcellular macromolecules in hepatocytes

AU - Cunningham, Michael L.

AU - Jay Gandolfi, A.

AU - Brendel, Klaus

AU - Glenn Sipes, I.

N1 - Funding Information: This research was supported by NIH Grant CA 21820.

PY - 1981/9/21

Y1 - 1981/9/21

N2 - Rat liver hepatocytes were used to bioactivate the aliphatic halides-carbon tetrachloride, trichloroethylene, and methylene chloride. Optimum bioactivation occured under a nitrogen atmosphere for carbon tetrachloride and under an oxygen atmosphere for trichloroethylene and methylene chloride. All were found to alkylate lipid and protein, while only carbon tetrachloride and trichloroethylene alkylated DNA and RNA.

AB - Rat liver hepatocytes were used to bioactivate the aliphatic halides-carbon tetrachloride, trichloroethylene, and methylene chloride. Optimum bioactivation occured under a nitrogen atmosphere for carbon tetrachloride and under an oxygen atmosphere for trichloroethylene and methylene chloride. All were found to alkylate lipid and protein, while only carbon tetrachloride and trichloroethylene alkylated DNA and RNA.

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U2 - 10.1016/0024-3205(81)90224-1

DO - 10.1016/0024-3205(81)90224-1

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JO - Life Sciences

JF - Life Sciences

IS - 12

ER -

Covalent binding of halogenated volatile solvents to subcellular macromolecules in hepatocytes

Abstract

ASJC Scopus subject areas

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