@article{a6b2c8dafcd34c709ecd49beeb556ada,
title = "CYP287A1 is a carotenoid 2-β-hydroxylase required for deinoxanthin biosynthesis in Deinococcus radiodurans R1",
abstract = "The carotenoid deinoxanthin is a crucial resistance factor against various stresses in the radiation-resistant bacterium Deinococcus radiodurans. Disruption of the gene dr2473 encoding the cytochrome P450 CYP287A1 led to the accumulation of 2-deoxydeinoxanthin in D. radiodurans, demonstrating that CYP287A1 is a novel β-carotene 2-hydroxylase. The dr2473 knockout mutant was shown to be more sensitive to UV radiation and oxidative stress than the wild-type strain D. radiodurans R1, indicating that the C2 alcohol of deinoxanthin is important for antioxidant activity.",
keywords = "2-β-hydroxylase, CYP287A1, Cytochrome P450, Deinococcus radiodurans, Deinoxanthin",
author = "Zhengfu Zhou and Wei Zhang and Shiyou Su and Ming Chen and Wei Lu and Min Lin and Istv{\'a}n Moln{\'a}r and Yuquan Xu",
note = "Funding Information: This work was supported by grants from the National Basic Research (973) Program of China (2015CB755700), the National High-Tech (863) Program of China (No. 2012AA02A703), the National Research and Development Project of Transgenic Crops of China (2014ZX08009-003), the National Natural Science Foundation of China (No. 31170105), and the US National Science Foundation (MCB-0948751 to IM). Funding Information: This work was supported by grants from the National Basic Research (973) Program of China (2015CB755700), and the National High-Tech (863) Program of China (No. 2012AA02A703), and the National Research and Development Project of Transgenic Crops of China (2014ZX08009-003), the National Natural Science Foundation of China (No. 31170105), and the US National Science Foundation (MCB-0948751 to IM). Publisher Copyright: {\textcopyright} 2015, Springer-Verlag Berlin Heidelberg.",
year = "2015",
month = dec,
day = "1",
doi = "10.1007/s00253-015-6910-9",
language = "English (US)",
volume = "99",
pages = "10539--10546",
journal = "Applied Microbiology and Biotechnology",
issn = "0175-7598",
publisher = "Springer Verlag",
number = "24",
}