Cys-tRNACys formation and cysteine biosynthesis in methanogenic archaea: Two faces of the same problem?

A. Ambrogelly; S. Kamtekar; A. Sauerwald; B. Ruan; D. Tumbula-Hansen; D. Kennedy; I. Ahel; D. Söll

doi:10.1007/s00018-004-4194-9

Cys-tRNA^Cys formation and cysteine biosynthesis in methanogenic archaea: Two faces of the same problem?

A. Ambrogelly
, S. Kamtekar
, A. Sauerwald
, B. Ruan
, D. Tumbula-Hansen
, D. Kennedy
, I. Ahel
, D. Söll

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Aminoacyl-tRNA (transfer RNA) synthetases are essential components of the cellular translation machinery as they provide the ribosome with aminoacyl-tRNAs. Aminoacyl-tRNA synthesis is generally well understood. However, the mechanism of Cys-tRNA^Cys formation in three methanogenic archaea (Methanocaldococcus jannaschii, Methanothermobacter thermautotrophicus and Methanopyrus kandleri) is still unknown, since no recognizable gene for a canonical cysteinyl-tRNA synthetase could be identified in the genome sequences of these organisms. Here we review the different routes recently proposed for Cys-tRNA^Cys formation and discuss its possible link with cysteine biosynthesis in these methanogenic archaea.

Original language	English (US)
Pages (from-to)	2437-2445
Number of pages	9
Journal	Cellular and Molecular Life Sciences
Volume	61
Issue number	19-20
DOIs	https://doi.org/10.1007/s00018-004-4194-9
State	Published - Oct 2004
Externally published	Yes

Keywords

Archaea
Cys-tRNA
Cysteine biosynthesis
Cysteinyl-tRNA synthetase
Methanogens

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Pharmacology
Cellular and Molecular Neuroscience
Cell Biology

Access to Document

10.1007/s00018-004-4194-9

Cite this

@article{45fa1442cf904bbf8327231070b9ee7e,

title = "Cys-tRNACys formation and cysteine biosynthesis in methanogenic archaea: Two faces of the same problem?",

abstract = "Aminoacyl-tRNA (transfer RNA) synthetases are essential components of the cellular translation machinery as they provide the ribosome with aminoacyl-tRNAs. Aminoacyl-tRNA synthesis is generally well understood. However, the mechanism of Cys-tRNACys formation in three methanogenic archaea (Methanocaldococcus jannaschii, Methanothermobacter thermautotrophicus and Methanopyrus kandleri) is still unknown, since no recognizable gene for a canonical cysteinyl-tRNA synthetase could be identified in the genome sequences of these organisms. Here we review the different routes recently proposed for Cys-tRNACys formation and discuss its possible link with cysteine biosynthesis in these methanogenic archaea.",

keywords = "Archaea, Cys-tRNA, Cysteine biosynthesis, Cysteinyl-tRNA synthetase, Methanogens",

author = "A. Ambrogelly and S. Kamtekar and A. Sauerwald and B. Ruan and D. Tumbula-Hansen and D. Kennedy and I. Ahel and D. S{\"o}ll",

year = "2004",

month = oct,

doi = "10.1007/s00018-004-4194-9",

language = "English (US)",

volume = "61",

pages = "2437--2445",

journal = "Cellular and Molecular Life Sciences",

issn = "1420-682X",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "19-20",

}

TY - JOUR

T1 - Cys-tRNACys formation and cysteine biosynthesis in methanogenic archaea

T2 - Two faces of the same problem?

AU - Ambrogelly, A.

AU - Kamtekar, S.

AU - Sauerwald, A.

AU - Ruan, B.

AU - Tumbula-Hansen, D.

AU - Kennedy, D.

AU - Ahel, I.

AU - Söll, D.

PY - 2004/10

Y1 - 2004/10

N2 - Aminoacyl-tRNA (transfer RNA) synthetases are essential components of the cellular translation machinery as they provide the ribosome with aminoacyl-tRNAs. Aminoacyl-tRNA synthesis is generally well understood. However, the mechanism of Cys-tRNACys formation in three methanogenic archaea (Methanocaldococcus jannaschii, Methanothermobacter thermautotrophicus and Methanopyrus kandleri) is still unknown, since no recognizable gene for a canonical cysteinyl-tRNA synthetase could be identified in the genome sequences of these organisms. Here we review the different routes recently proposed for Cys-tRNACys formation and discuss its possible link with cysteine biosynthesis in these methanogenic archaea.

AB - Aminoacyl-tRNA (transfer RNA) synthetases are essential components of the cellular translation machinery as they provide the ribosome with aminoacyl-tRNAs. Aminoacyl-tRNA synthesis is generally well understood. However, the mechanism of Cys-tRNACys formation in three methanogenic archaea (Methanocaldococcus jannaschii, Methanothermobacter thermautotrophicus and Methanopyrus kandleri) is still unknown, since no recognizable gene for a canonical cysteinyl-tRNA synthetase could be identified in the genome sequences of these organisms. Here we review the different routes recently proposed for Cys-tRNACys formation and discuss its possible link with cysteine biosynthesis in these methanogenic archaea.

KW - Archaea

KW - Cys-tRNA

KW - Cysteine biosynthesis

KW - Cysteinyl-tRNA synthetase

KW - Methanogens

UR - https://www.scopus.com/pages/publications/9744273252

UR - https://www.scopus.com/pages/publications/9744273252#tab=citedBy

U2 - 10.1007/s00018-004-4194-9

DO - 10.1007/s00018-004-4194-9

M3 - Review article

C2 - 15526152

SN - 1420-682X

VL - 61

SP - 2437

EP - 2445

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

IS - 19-20

ER -